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[1]龚正华,黄建安.瑞舒伐他汀对COPD患者血清白介素8及生活质量的影响[J].医学研究与战创伤救治(原医学研究生学报),2015,17(01):57-60.[doi:10.3969/j.issn.1672-271X.2015.01.019]
　GONG Zheng-hua,HUANG Jian-an.The observation of rosuvastatin affect on IL-8 and the quality of life on COPD patients[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(01):57-60.[doi:10.3969/j.issn.1672-271X.2015.01.019]
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瑞舒伐他汀对COPD患者血清白介素8及生活质量的影响()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第17卷
期数:
2015年01期
页码:
57-60
栏目:
出版日期:
2015-01-31

文章信息/Info

Title:
The observation of rosuvastatin affect on IL-8 and the quality of life on COPD patients
作者:
龚正华1; 2; 黄建安2
1.215600 江苏张家港，张家港市中医医院呼吸内科；2.215000 江苏苏州，苏州大学第一附属医院呼吸内科
Author(s):
GONG Zheng-hua1; 2;  HUANG Jian-an2．
1.Department of Respiratory， Hospital of Traditional Chinese Medicine of Zhangjiagang City， Zhangjiagang， Jiangsu 215600， China； 2.Department of Respiratory， The First Affiurted Hospital of Soochow University， Suzhou， Jiangsu 215000， China
关键词:
瑞舒伐他汀; 慢性阻塞性肺疾病; 白介素8; 生活质量
Keywords:
rosuvastatin;  COPD;  interleukin-8;  quality of life
分类号:
R563.3
DOI:
10.3969/j.issn.1672-271X.2015.01.019
文献标志码:
A
摘要:
目的 探讨对于慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD)稳定期患者给予口服瑞舒伐他汀16周后血清白介素8(IL-8)水平、肺功能及生活质量的影响，并观察使用他汀类药物干预后对患者远期(1年)COPD急性加重(acute exacerbation of COPD，AECOPD)次数的影响。方法 COPD门诊及出院患者随机分组，分为治疗组40例，对照组42例。治疗组40例在常规治疗的基础上口服瑞舒伐他汀20 mg，1/d，治疗后16周后复诊观察患者血清IL-8、肺功能(FEV1及FEV1/FVC)、圣乔治呼吸问卷评分(St Georges respiratory questionnaire scores，SGRQ)评估生活质量。随访1年，记录1年内患者出现AECOPD的次数及住院次数。结果 治疗组和对照组比较，治疗组在第16周时血清IL-8水平较对照组下降(P＜0.05)，肺功能FEV1及FEV1/FVC较对照组改善(P＜0.05)，SGRQ评分较对照组增加，但差异无统计学意义(P＞0.05)。远期观察治疗组患者急性加重次数和住院次数较对照组减少(P＜0.05)。结论 瑞舒伐他汀有助于改善COPD患者的肺功能及生活质量，并有减少远期急性加重的临床效应。
Abstract:
Objective To investigate the effect of oral rosuvastatin treatment of stable COPD patients on the blood IL-8， lung function and quality of life， after short-term (16 weeks) and long-term observation of the times of acute exacerbation of COPD (AECOPD) after the intervention (1 year). Methods The outpatients and discharged patients with COPD were randomly divided into treatment group 40 cases and control group 42 groups， the treatment group were treated with rosuvastatin 20 mg QN on the basis of routine treatment. 16 weeks after operation we observed all patients serum IL-8， lung function (FEV1 and FEV1/FVC)， and quality of life (St Georges respiratory questionnaire scores). We recorded the frequency of AECOPD and hospitalization followed up for 1 year. Results Compared with the treatment group and control group at sixteenth weeks， the blood IL-8 level in the patients in the treatment group decreased (P<0.05)， pulmonary function of FEV1 and FEV1/FVC improved (P<0.05)， SGQR score increased， but there was no statistical difference (P＞0.05). The data of long-term observation shows the patients in the treatment group has less times of acute exacerbation and hospitalization times than the control group (P<0.05). Conclusion The rosuvastatin improves lung function and quality of life in patients with COPD， and has long-term clinical effect in reducing acute exacerbation.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2015-01-20