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[1]洪 骏,唐海霞,戴 雯,等.中性粒细胞中毒颗粒与降钙素原联合检测对细菌性肺炎诊断的意义[J].医学研究与战创伤救治(原医学研究生学报),2015,17(02):146-148.[doi:10.3969/j.issn.1672-271X.2015.02.010]
　HONG Jun,TANG Hai-xia,DAI Wen,et al.The clinical significance of neutrophil toxic granulation and PCT in the patients with bacterial pneumonia[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(02):146-148.[doi:10.3969/j.issn.1672-271X.2015.02.010]
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中性粒细胞中毒颗粒与降钙素原联合检测对细菌性肺炎诊断的意义()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第17卷
期数:
2015年02期
页码:
146-148
栏目:
出版日期:
2015-04-22

文章信息/Info

Title:
The clinical significance of neutrophil toxic granulation and PCT in the patients with bacterial pneumonia
作者:
洪 骏; 唐海霞; 戴 雯; 吴 嘉
210002 江苏南京，南京军区南京总医院全军临床检验医学研究所
Author(s):
HONG Jun;  TANG Hai-xia;  DAI Wen;  WU Jia.
Institute of Laboratory Medicine Science of PLA， Nanjing General Hospital of Nanjing Military Region， PLA， Nanjing， Jiangsu 210002， China
关键词:
细菌性肺炎; 中毒颗粒; 炎症; 降钙素原
Keywords:
bacterial pneumoniain;  toxic granulation;  inflammation;  PCT
分类号:
R563.1
DOI:
10.3969/j.issn.1672-271X.2015.02.010
文献标志码:
A
摘要:
目的 观察细菌性肺炎患者外周血中性粒细胞中毒颗粒（toxic granulation，TG），分析中性粒细胞毒性指数（neutrophils toxicity granulation index，TG %）与炎症指标的相关性，探讨细菌性肺炎患者中性粒细胞中毒颗粒检测的临床意义。方法 分别检测并比较88例细菌性肺炎患者和100例健康对照者的外周血TG %、血清降钙素原(procaicltonin，PCT)、C反应蛋白（C-reactive protein，CRP）、白细胞计数(white blood cell，WBC)、中性粒细胞百分比（neutrophilic granulocyte percentage，NEUT %）及中性粒细胞计数（neutrophil count，NEUT#）水平，探讨细菌性肺炎患者TG %与PCT、CRP、WBC、NEUT %间的相关性；同时对细菌性肺炎患者入院治疗前、后的TG %及各炎症指标变化进行比较。 结果 细菌性肺炎患者TG %、WBC、NEUT %、NEUT# 及PCT、CRP水平与正常对照组比较均显著升高（P<0.05）。TG %与PCT（r=0.532，P<0.01）、CRP（r=0.392，P<0.01）、WBC（r=0.346，P<0.01）、NEUT %(r=0.512，P<0.01)、NEUT#（r=0.467，P<0.01）均呈显著正相关。细菌性肺炎患者入院治疗后的TG %、PCT、CRP水平明显降低（P均<0.05）。结论 TG %可反映体内炎症水平，有助于监测细菌性肺炎患者的病情。
Abstract:
Objective By observing the patients with bacterial pneumonia in the peripheral blood neutrophils toxic granulation (TG) and analysis of the correlation between neutrophils toxicity granulation index (TG %) and inflammation makers， to investigate the clinical significance of the TG in the patients with bacterial pneumonia. Methods We measured and compared the level of TG %， C- reactive protein (CRP)， White blood cell count (WBC)， Neutrophil percentage (NEUT %)， Neutrophil count (NEUT#) and Procalciton (PCT) in 88 cases of bacterial pneumonia and 100 cases of Healthy people， to investigate the correlation between the TG % and the PCT， CRP， and WBC. At the same time， we compared the TG % and other inflammation makers of the patients with bacterial pneumonia in the hospital before and after. Results The TG %， CRP， PCT， WBC， NEUT % and NEUT# of the patients were significantly increased than that of control group (P<0.05). The correlative coefficients were PCT (r=0.532， P<0.01)， CRP (r=0.392， P<0.01)， WBC (r=0.346， P<0.01)， NEUT % (r=0.512， P<0.01)， NEUT# (r=0.467， P<0.01). All was significantly positively related. The TG %， PCT and CRP were significant decrease after treatment in the hospital (P<0.05). Conclusion TG % can reflect the level of inflammation in the body， helps to monitor the condition of patients with bacterial pneumonia.

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更新日期/Last Update: 2015-03-20