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[1]代海滨,徐苗苗,李伟彦,等.塞来昔布多模式镇痛用于妇科子宫切除手术的临床研究[J].医学研究与战创伤救治(原医学研究生学报),2015,17(03):229-232.[doi:10.3969/j.issn.1672-271X.2015.03.002]
　DAI Hai-bin,XU Miao-miao,LI Wei-yan,et al.Clinical study on multimodal analgesia effect of celecoxib in gynecologic hysterectomy[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(03):229-232.[doi:10.3969/j.issn.1672-271X.2015.03.002]
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塞来昔布多模式镇痛用于妇科子宫切除手术的临床研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第17卷
期数:
2015年03期
页码:
229-232
栏目:
出版日期:
2015-05-20

文章信息/Info

Title:
Clinical study on multimodal analgesia effect of celecoxib in gynecologic hysterectomy
作者:
代海滨; 徐苗苗; 李伟彦; 朱四海; 嵇 晴; 吴智方; 段满林; 徐建国
210002 江苏南京，第二军医大学南京临床医学院（南京军区南京总医院）麻醉科
Author(s):
DAI Hai-bin;  XU Miao-miao;  LI Wei-yan;  ZHU Si-hai;  JI Qing;  WU Zhi-fang;  DUAN Man-lin;  XU Jian-guo.
Department of Anesthesiology， Nanjing General Hospital of Nanjing Military Command， Nanjing Clinical Medical College of the Second Military Medical University, Nanjing， Jiangsu 210002， China
关键词:
塞来昔布; 多模式镇痛; 超前镇痛; 术后镇痛; 疼痛
Keywords:
celecoxib;  multimodal analgesia;  preemptive analgesia;  postoperative analgesia;  pain
分类号:
R713.42
DOI:
10.3969/j.issn.1672-271X.2015.03.002
文献标志码:
A
摘要:
目的 观察塞来昔布多模式镇痛用于妇科经腹子宫切除手术的术后镇痛效应。方法 将择期手术的患者随机分为超前镇痛组、术后镇痛组和对照组三组，每组各20例。超前镇痛组：术前2 h给予患者口服塞来昔布200 mg，术后距第一次给药12 h、24 h再次分别口服200 mg。术后镇痛组：术后即刻口服塞来昔布200 mg，术后距第一次给药12 h、24 h再次分别口服200 mg。对照组：术前2 h给予口服安慰药，术后距第一次给药12 h、24 h再次分别口服安慰药。安慰药为复合维生素片。观察三组的患者，术后静息状态和运动状态的VAS评分；术后4个时间段的吗啡用量以及术后24 h、48 h的吗啡总用量。结果 塞来昔布术前使用或术后使用，都在术后早期（12 h），对静息和运动状态的疼痛，镇痛效果较对照组优越(P<0.05)。而且，在术后极早期（6 h），术前使用较术后使用对术后运动状态的疼痛，镇痛效果更优越(P<0.05)。在吗啡用量方面，塞来昔布术前使用或术后使用，都可以在术后早期（术后24 h内），较对照组减少吗啡的用量(P<0.05)；而且，术前使用较对照组，对吗啡的总用量（24 h和48 h），减少更明显(P<0.05)。结论 塞来昔布术前、术后都应使用，并且术前开始使用对静息及运动状态疼痛的镇痛效果更优越，并减少吗啡的用量更明显。
Abstract:
Objective To determine the multimodal analgesia effect of celecoxib and its influence on systemic inflammatory reaction in gynecologic transabdominal hysterectomy. Methods The subjects undergoing transabdominal hysterectomy were randomly divided into three groups， 20 cases in each group. The preemptive analgesia group， giving the patient oral celecoxib 200 mg 2 h before operation， followed orally administered 200 mg again from the first postoperative administration of 12 h， 24 h； Postoperative analgesia group， immediately oral administration of celecoxib 200 mg at the time point of operation completed， oral 200 mg again from the first postoperative administration of 12 h and 24 h respectively； The control group， give oral placebo 2 h before surgery， oral placebo again from the first postoperative administration of 12 h and 24 h respectively. The placebo was vitamin compound. The VAS score in both resting state and motion state at 4 time points， postoperative morphine dosage and morphine total dosage of postoperative 24 h and 48 h， in different groups were evaluated. Results Compared with the control group， the analgesic effect of the preemptive analgesia group and postoperative analgesia group at postoperative 6 h and 12 h in both status was significantly superior， and there were significant differences (P<0.05). But analgesic effect of celecoxib used before surgery at the very early after operation (6 h) in exercise status was superior to celecoxib postoperative use. In postoperative 24 h， morphine consumption in the control group was higher than that of the preemptive analgesia group and postoperative analgesia group (P<0.05). Total morphine consumption of the preemptive analgesia group in postoperative 24 h or 48 h was lower than that of the control group (P<0.05). Conclusion Celecoxib should be used to improve the analgesic effect before and after operation. Especially analgesic effect of celecoxib used before surgery is best in three groups in both status and morphine consumption of the preemptive analgesia group is lower than that of the control group.

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备注/Memo

备注/Memo:
国家自然科学基金项目（81102514）
更新日期/Last Update: 2015-05-20