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[1]王苏梦,吴 嘉,牛冬梅,等.急性冠脉综合征患者NT-proBNP、RDW和CRP的水平及相关性研究[J].医学研究与战创伤救治(原医学研究生学报),2015,17(04):362-364.[doi:10.3969/j.issn.1672-271X.2015.04.008]
　WANG Su-meng,WU Jia,NIU Dong-mei,et al.Study of plasma level of NT-proBNP, CRP and RDW in acute coronary syndrome patients[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(04):362-364.[doi:10.3969/j.issn.1672-271X.2015.04.008]
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急性冠脉综合征患者NT-proBNP、RDW和CRP的水平及相关性研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第17卷
期数:
2015年04期
页码:
362-364
栏目:
出版日期:
2015-07-20

文章信息/Info

Title:
Study of plasma level of NT-proBNP, CRP and RDW in acute coronary syndrome patients
作者:
王苏梦; 吴 嘉; 牛冬梅; 汪俊军
210002 江苏南京，南京军区南京总医院临床检验科
Author(s):
WANG Su-meng;  WU Jia;  NIU Dong-mei;  WANG Jun-jun.
Department of Clinical Laboratory， Nanjing General Hospital of Nanjing Military Command， Nanjing， Jiangsu 210002， China
关键词:
N-末端B型钠尿肽前体; 红细胞分布宽度; C反应蛋白; 急性冠脉综合征
Keywords:
NT-proBNP;  RDW;  CRP;  acute coronary syndrome
分类号:
R541.4
DOI:
10.3969/j.issn.1672-271X.2015.04.008
文献标志码:
A
摘要:
目的 探讨联合检测血清N-末端B型钠尿肽前体(NT-proBNP)、C-反应蛋白(CRP)及红细胞分布宽度(RDW)3种标志物在急性冠脉综合征(ACS)的水平变化并探讨其相关性。方法 检测69例ACS患者、90例稳定型冠心病(CAD)患者和67例体检健康者血清NT-proBNP、全血CRP和RDW水平，分析3个指标的相关性。结果 NT-proBNP、RDW和CRP水平在ACS患者中水平分别为520.50(216.65~1360.50)pmol/L、13.60(12.90~14.40)%、13.00(7.05~50.50)mg/L，明显高于CAD患者:20.89(8.91~47.03)pmol/L、 13.25(12.80~13.80)%、 3.00(1.00~5.25)mg/L和健康人群4.06(2.10~13.01)pmol/L、13.00(12.70~13.60)%、1.00(0.50~3.30)mg/L。在ACS患者中，NT-proBNP和RDW、CRP均有明显的相关性(r=0.403，r=0.533，P<0.01)，而在CAD患者中，NT-proBNP仅与RDW相关(r=0.373，P<0.01)。结论 ACS患者NT-proBNP、CRP和RDW的水平明显升高并具有相关性，3项联合检测有助于ACS的临床诊断。
Abstract:
Objective This study was to investigate plasma NT-proBNP, CRP and RDW levels in acute coronary syndrome(ACS) and stable CAD patients and to evaluate the relationship of them. Methods Plasma NT-proBNP, red cell distribution width (RDW) and C-reactive protein (CRP) levels were determined in 69 ACS, 90 stable CAD patients and 67 controls. The correlation analyses and multiple linear regression analyses were performed. Results Plasma NT-proBNP, RDW and CRP levels show 20.50 (216.65-1360.50)pmol/L, 13.60 (12.90-14.40)%, 13.00 (7.05-50.50)mg/L respectively, they were significantly elevated than patients with CAD 20.89 (8.91-47.03)pmol/L, 13.25 (12.80-13.80)%, 3.00 (1.00-5.25)mg/L and controls 4.06 (2.10-13.01)pmol/L, 13.00 (12.70-13.60)%, 1.00 (0.50-3.30)mg/L. NT-proBNP levels were positively correlated with CRP and RDW in ACS patients (r=0.403, r=0.533, P<0.01), and only RDW were positively correlated with NT-proBNP levels in stable CAD patients(r=0.373, P<0.01). Conclusion Plasma NT-proBNP, CRP and RDW levels were significantly higher in ACS patients and elevated NT-proBNP levels were independently associated with RDW, CRP in ACS.

参考文献/References:

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备注/Memo

备注/Memo:
南京军区南京总医院院管课题(2012049)
更新日期/Last Update: 2015-07-20