|本期目录/Table of Contents|

[1]杨 玲.D-二聚体、纤维蛋白原及抗凝血酶Ⅲ联合检测对早期2型糖尿病肾病的诊断价值[J].医学研究与战创伤救治(原医学研究生学报),2015,17(04):402-403，436.[doi:10.3969/j.issn.1672-271X.2015.04.021]
　YANG Ling..The significance of detection of D-dimer, fibrinogen and antithrombin-Ⅲ in the patients with typy-2 diabetic nephropathy[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(04):402-403，436.[doi:10.3969/j.issn.1672-271X.2015.04.021]
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D-二聚体、纤维蛋白原及抗凝血酶Ⅲ联合检测对早期2型糖尿病肾病的诊断价值()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第17卷
期数:
2015年04期
页码:
402-403，436
栏目:
出版日期:
2015-07-20

文章信息/Info

Title:
The significance of detection of D-dimer, fibrinogen and antithrombin-Ⅲ in the patients with typy-2 diabetic nephropathy
作者:
杨 玲
213011 江苏常州，常州市第七人民医院内分泌科
Author(s):
YANG Ling.
Department of Endocrinology， The Seventh Peoples Hospital， Changzhou， Jiangsu 213011， China
关键词:
D-二聚体; 纤维蛋白原; 抗凝血酶Ⅲ; 2 型糖尿病; 糖尿病肾病
Keywords:
D-dimer;  fibrinogen;  antithrombin Ⅲ;  type 2 diabetes;  diabetic nephropathy
分类号:
R587.2;R692.9
DOI:
10.3969/j.issn.1672-271X.2015.04.021
文献标志码:
A
摘要:
目的 探究D-二聚体、纤维蛋白原(FIB)及抗凝血酶Ⅲ(AT-Ⅲ)联合检测2 型糖尿病早期肾损伤的临床诊断价值。方法 选取某院2型糖尿病患者206例，根据24 h尿白蛋白排泄率(UAE)分为无蛋白尿组116例(UAE＜30 mg/24 h)与微量白蛋白尿组90例(30 mg/24 h≤UAE＜300 mg/24 h)，并选取同期健康体检者103例作为健康对照组，比较血浆D-二聚体、FIB、AT-Ⅲ3项指标的变化。结果 微量白蛋白尿组D-二聚体、FIB含量明显高于无蛋白尿组和健康对照组，差异均有统计学意义(P＜0.05)，而三组AT-Ⅲ的活性比较差异无统计学意义(P>0.05)。3项指标联合检测的微量蛋白尿组患者为93.3%，比单项检测的阳性率高，差异有统计学意义(P＜0.05)。D-二聚体、FIB、AT-Ⅲ与尿白蛋白排泄率呈正相关，相关系数(r)依次为0.812、0.672、0.621(P＜0.05)。结论 D-二聚体、FIB检测对于2型糖尿病肾病的早期判断以及疾病的早期预防和病情监测有重要意义。
Abstract:
Objective To explore the D-dimer, fibrinogen (FIB), antithrombin Ⅲ (AT-Ⅲ) joint detection of early renal damage in type 2 diabetes to assess the diagnostic value of clinical application. Methods According to the 24 h urine albumin excretion rate (UAE), 206 patients selected from type 2 diabetes patients were divided into 116 cases without albuminuria group (UAE< 30 mg/24 h) and microalbuminuria group 90 cases (30 mg/24 h ≤UAE＜ 300 mg/24 h), and select the healthy physical examination is 103 people for the same period as the healthy control group, comparison of plasma D-dimer, FIB, the AT-Ⅲ three indicators of change. Results Microalbuminuria group D-dimer, FIB levels were significantly higher than those without albuminuria group and healthy control group, the difference had statistical significance (P<0.05), and comparison of three groups of the AT-Ⅲ activity, there was no statistically significant difference (P>0.05). Three indicators of joint detection of trace albuminuria group of patients was 93.3%, positive rate than single detection are high, the difference was statistically significant (P<0.05). D-dimer, FIB, the AT-Ⅲ and UAE are positively related to the level of the correlation coefficient r of 0.812, 0.672, and 0.621 (P< 0.05). Conclusion The detection of D-dimer, FIB in type 2 diabetic nephropathy early judgement and early prevention of disease and illness monitoring is important.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2015-07-20