[1]刘蓉,张丹,杨玲.2型糖尿病患者尿微量白蛋白与左室肥厚的关系[J].医学研究与战创伤救治(原医学研究生学报),2015,17(05):506-507，543.[doi:10.3969/j.issn.1672-271X.2015.05.018]
　LIU Rong,ZHANG Dan,YANG Ling..The relationship between microalbuminuria and left ventricular hypertrophy in type 2 diabetes[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(05):506-507，543.[doi:10.3969/j.issn.1672-271X.2015.05.018]
点击复制

2型糖尿病患者尿微量白蛋白与左室肥厚的关系()

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第17卷
期数:
2015年05期
页码:
506-507，543
栏目:
出版日期:
2015-09-30

文章信息/Info

Title:
The relationship between microalbuminuria and left ventricular hypertrophy in type 2 diabetes
作者:
刘蓉; 张丹; 杨玲
213011 江苏常州，常州市第七人民医院内分泌科
Author(s):
LIU Rong;  ZHANG Dan;  YANG Ling.
Department of Endocrinology and Metabolism， Affiliated Changzhou Seventh People’s Hospital， Changzhou， Jiangsu 213011 ， China
关键词:
2型糖尿病; 左室肥厚; 尿微量白蛋白
Keywords:
type 2 diabetes;  left ventricular hypertrophy;  microalbuminuria
分类号:
R587.1
DOI:
10.3969/j.issn.1672-271X.2015.05.018
文献标志码:
A
摘要:
目的 探讨2型糖尿病患者尿微量白蛋白水平与左心室肥厚的关系。方法 2型糖尿病患者136例，接受超声心动图检查，计算左室质量指数（LVMI），采用LVMI男性 >125 g/m2、女性>110 g/m2作为左心室肥厚（LVH）的标准。测定24 h尿白蛋白水平，分为正常白蛋白尿组、微量白蛋白尿组、大量白蛋白尿组，比较三组LVMI值及LVH发生率，将 LVMI与24 h尿白蛋白水平进行相关性分析。结果 随24 h白蛋白水平增高，2型糖尿病患者LVMI升高，左室肥厚发生率增加，LVMI与24 h尿白蛋白水平呈正相关关系（r=0.211，P＜ 0.05）。结论 2型糖尿病患者出现尿微量白蛋白时发生左室肥厚风险增加，有助于早期识别2型糖尿病患者心血管疾病的发生。
Abstract:
Objective To study the relationship between microalbuminuria and left ventricular hypertrophy in type 2 diabetes(T2DM). Methods 136 patients diagnosed with T2DM accepted color Doppler echocardiogram. Calculated the left ventricular mass index(LVMI). LVH was defined as follows： LVMI >125 g/m2 for men and LVMI > 110 g/m2 for women. According to the 24 h Urinary albumin levels， they were divided into three groups：normal urinary albumin group ， microalbuminuria group and macroabuminuria group．Compare LVMI values and rate of LVH among three groups. LVMI and 24 h urinary albumin level was explored by correlation analysis. Results With the increase of 24 h protein level， the level of LVMI increased in patients with type 2 diabetes， and the incidence of left ventricular hypertrophy increased. The level of LVMI was positively correlated with the level of 24 h urinary albumin (r=0.211， P<0.05). Conclusion The risk of the LVH in type 2 diabetes mellitus increased when present with albuminuria. Measure albuminuria may help to identify cardiovascular disease in patients with type 2 diabetes mellitus.

参考文献/References:

[1]Gerstein HC，Mann JF，Yi Q，et al.Albuminuria and risk of cardiovascular events，death，and heart failure in diabetic and nondiabetic individuals[J].JAMA ，2001，286(4):421-426.
[2]Devereux RB，Reichek N.Echocardiographic determination of left ventricular mass in man：anatomic validation of the method[J].Circulation，1977，55 （4）:613-618.
[3]Wu N，Zhao W，Ye K，et al.Albuminuria is associated with left ventricular hypertrophy in patients with early diabetic kidney disease[J].Int J Endocrinol， 2014，doi: 10.1155/2014/351945.
[4]Santra S，Basu AK，Roychowdhury P，et al.Comparison of left ventricular mass in normotensive type 2 diabetes mellitus patients with that in the nondiabetic population[J].J Cardiovasc Dis Res，2011，2(1):50-56.
[5]DSouza A，Howarth FC，Yanni J，et al.Chronic effects of mild hyperglycaemia on left ventricle transcriptional profile and structural remodelling in the spontaneously type 2 diabetic Goto-Kakizaki rat[J].Heart Fail Rev，2014，19(1):65-74.
[6]Gupta J，Mitra N，Kanetsky PA，et al.Association between albuminuria，kidney function，and inflammatory biomarker profile in CKD in CRIC[J].Clin J Am Soc Nephrol，2012，7(12):1938-1946.
[7]Gupta J，Dominic EA，Fink JC，et al.Association between inflammation and cardiac geometry in chronic kidney disease:findings from the CRIC Study[J].PLoS One，2015，10(4):e0124772.doi: 10.1371/journal.pone.0124772.
[8] Mano Y，Anzai T，Kaneko H，et al.Overexpression of human C-reactive protein exacerbates left ventricular remodeling in diabetic cardiomyopathy[J].Circ J ，2011，75(7):1717-1727.
[9]Kamiyama M，Urushihara M，Morikawa T，et al.Oxidative stress/angiotensinogen/renin-angiotensin system axis in patients with diabetic nephropathy[J].Int J Mol Sci，2013，14(11):23045-23062.
[10]葛 晓.胰岛素抵抗在糖尿病肾病发生、发展中的作用研究进展[J].国际泌尿系统杂志，2011，31(4):562-565.
[11]周 江，文 萍，肖 秋.老年2型糖尿病患者心脏功能改变与胰岛素抵抗的关系[J].东南国防医药，2014，16(3):308-309.
[12]张一驰，牟艳玲，解砚英.肾素-血管紧张素系统与糖尿病心肌病关系的研究进展[J].生理科学进展，2011，42(4):269-275.

相似文献/References:

[1]潘全民.老年2型糖尿病患者步行前后血糖变化分析[J].医学研究与战创伤救治(原医学研究生学报),2013,15(05):525.[doi:10.3969/j.issn.1672-271X.2013.05.039]
[2]杜振双,张诚华.BillrothⅡ式胃切除术对患者血糖的影响[J].医学研究与战创伤救治(原医学研究生学报),2013,15(01):62.
[3]王佳薇,李 冰,郑玲玉.2型糖尿病158例临床路径护理分析[J].医学研究与战创伤救治(原医学研究生学报),2012,14(02):168.
[4]王加林,王 猛,杨文娟,等.131I治疗甲状腺功能亢进症合并2型糖尿病101例[J].医学研究与战创伤救治(原医学研究生学报),2011,13(02):109.
　WANG Jia-lin,WANG Meng,YANG Wen-juan,et al.Clinical study of 131I on the treatment of 101 cases of hyperthyroidism patients with type 2 diabetes mellitus[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(05):109.
[5]张群燕,蔡 辉,董晓蕾,等.卡托普利对实验大鼠左室肥厚的干预作用[J].医学研究与战创伤救治(原医学研究生学报),2010,12(01):6.
　ZHANG Qun-yan,CAI Hui,DONG Xiao-lei,et al.Regressing left ventricular hypertrophy by captopril in rat with pressure overload[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(05):6.
[6]何述莉,董立新,施能彬,等.检测2型糖尿病患者尿微量白蛋白的临床意义[J].医学研究与战创伤救治(原医学研究生学报),2009,11(03):255.
[7]王 静,阮 芸,谭擎缨,等.α-酮酸在早期2型糖尿病肾病治疗中 的作用[J].医学研究与战创伤救治(原医学研究生学报),2008,10(06):426.
　WANG Jing,RUAN Yun,TAN Qing-ying,et al.The effect of α-keto acid on early diabetic nephropathy in type 2 diabetes mellitus[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2008,10(05):426.
[8]王 静,彭永平,宫剑滨,等.前列地尔对冠心病合并糖尿病患者介入治疗后造影剂肾病的影响[J].医学研究与战创伤救治(原医学研究生学报),2014,16(01):28.
　WANG Jing,PENG Yong-ping,GONG Jian-bin,et al.Effect of alprostadil on contrast-induced nephropathy in coronary heart disease patients with type 2 diabetes undergoing percutaneous coronary intervention[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(05):28.
[9]王爱民,徐向进,熊晓琴,等.2型糖尿病患者长期家庭血糖监测的随访分析[J].医学研究与战创伤救治(原医学研究生学报),2014,16(01):40.
　WANG Ai-min,XU Xiang-jin,XIONG Xiao-qin,et al.Following-up and nursing patients with type 2 diabetes mellitus by a long-term blood glucose monitoring at home[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(05):40.
[10]王静,谭擎缨,阮勇,等.2型糖尿病患者体脂含量及分布与血清内脂素水平的相关研究[J].医学研究与战创伤救治(原医学研究生学报),2014,16(05):465.[doi:10.3969/j.issn.1672-271X.2014.05.006]
　WANG Jing,TANG Qing-ying,RUAN Yong,et al.The relationship of visfatin with body fat content and fat distribution in type 2 diabetes[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(05):465.[doi:10.3969/j.issn.1672-271X.2014.05.006]

备注/Memo

备注/Memo:
-
更新日期/Last Update: 2015-09-20