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[1]刘丽萍.不同硬化剂瘤内注射治疗对子宫肌瘤患者内分泌状态的影响[J].医学研究与战创伤救治(原医学研究生学报),2015,17(06):622-625.[doi:10.3969/j.issn.1672-271X.2015.06.019]
　LIU Li-ping..Effect of uterine fibroids endocrine status of patients in different hardeners intratumoral injection[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(06):622-625.[doi:10.3969/j.issn.1672-271X.2015.06.019]
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不同硬化剂瘤内注射治疗对子宫肌瘤患者内分泌状态的影响()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第17卷
期数:
2015年06期
页码:
622-625
栏目:
出版日期:
2015-12-15

文章信息/Info

Title:
Effect of uterine fibroids endocrine status of patients in different hardeners intratumoral injection
作者:
刘丽萍
266300 山东胶州，山东省青岛市胶州市现代医院妇产科
Author(s):
LIU Li-ping.
Department of Obstetrics and Gynecology,the Modern Hospital of Qingdao, Jiaozhou, Shandong 266300, China
关键词:
聚桂醇; 无水乙醇; 子宫肌瘤; 内分泌
Keywords:
lauromacrogol;  ethanol;  uterine fibroids;  endocrine
分类号:
R453.9
DOI:
10.3969/j.issn.1672-271X.2015.06.019
文献标志码:
A
摘要:
目的 探讨不同硬化剂瘤内注射治疗对子宫肌瘤患者的临床疗效及内分泌状态的影响。方法 选取自2013年1月-2014年1月我院收治的90例子宫肌瘤患者，按随机数表法将其分为对照组和观察组，每组各45例。两组患者均在超声引导下经阴道瘤内注射硬化剂治疗，对照组患者给予无水乙醇治疗，观察组患者给予聚桂醇注射液治疗，观察并比较两组患者治疗后的临床疗效、不良反应及内分泌激素分泌水平。结果 观察组患者治疗后子宫肌瘤直径、体积分别为（2.3±0.7）cm、（26.2±8.4）cm3，对照组患者治疗后肌瘤直径、体积分别为（2.4±0.8）cm、（25.8±8.7）cm3，与治疗前相比差异具统计学意义（P<0.05），但两组间比较差异无统计学意义（P>0.05）。两组患者治疗前后血清中P、LH、TSH水平均未发生较大变化（P>0.05），血清E2水平与治疗前相比明显降低（P＜0.05），但两组间比较差异无统计学意义（P>0.05）；观察组患者治疗后不良反应的总发生率为17.8%，明显低于对照组（P＜0.05）。结论 超声引导下瘤内注射聚桂醇和无水乙醇硬化治疗子宫肌瘤的疗效相当，均能有效缩小肌瘤的直径及体积，对子宫肌瘤患者内分泌状态的影响均较小，但聚桂醇瘤内注射治疗后的安全性更高，不良反应较无水乙醇少，值得在临床上推广应用。
Abstract:
Objective To investigate the clinical efficacy and endocrine status of different sclerosing agent injection therapy for tumor patients with uterine fibroids. Methods 90 patients with uterine fibroids were selected in our hospital from January 2013 to January 2014. According to a random number table method, they were randomly divided into control group (45 cases ) and observation group(45 cases). Two groups of patients were gaven ultrasound-guided sclerotherapy treatment of vaginal tumors. The control group were treated with ethanol treatment, and the observation group were given lauromacrogol injection treatment. Compared the clinical efficacy, adverse reactions and hormone secretion status of two groups after treatment. Results The uterine fibroids diameter and volume in observation group after treatment were (2.3 ± 0.7) cm and (26.2±8.4) cm3 respectively, while in the control group were (2.4 ± 0.8) cm and (25.8±8.7) cm3 respectively. There was significant difference compared with before and after treatment (P<0.05), but there was no statistically significant difference between the two groups (P>0.05). Serum P, LH, TSH levels in two groups of patients did not changed, and the difference was not statistically significant (P>0.05). Serum E2 levels decreased significantly compared with that before treatment (P<0.05), but no significant difference was found between the two groups (P>0.05); overall incidence of adverse reactions in observation group (17.8%) was significantly lower than the control group (P<0.05). Conclusion Under the guidance of ultrasound, the efficacy of the treatment with intratumoral injection lauromacrogol or ethanol was similar, can effectively reduce fibroids diameter and volume, and the influence on the levels of sex hormones, endocrine status of patients with uterine fibroids are small. But intratumoral injection with lauromacrogol is more safety and lead less adverse effects than anhydrous ethanol, worthy of clinical application.

参考文献/References:

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2015-11-20