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[1]杨 婧,赵 斌,李晓红,等.术后颅内感染菌种分布、危险因素与结局分析[J].医学研究与战创伤救治(原医学研究生学报),2016,18(03):233-236.[doi:10.3969/j.issn.1672-271X.2016.03.003]
　YANG Jing,ZHAO Bin,LI Xiao-hong,et al.A study of typing ST11 of klebsiella pneumoniae producing carbapenemases by matrix-assisted laser desorption ionization-time of flight mass spectrometry[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2016,18(03):233-236.[doi:10.3969/j.issn.1672-271X.2016.03.003]
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术后颅内感染菌种分布、危险因素与结局分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第18卷
期数:
2016年03期
页码:
233-236
栏目:
出版日期:
2016-06-30

文章信息/Info

Title:
A study of typing ST11 of klebsiella pneumoniae producing carbapenemases by matrix-assisted laser desorption ionization-time of flight mass spectrometry
作者:
杨 婧1; 赵 斌2; 李晓红3; 于笑难4
1. 110840辽宁沈阳，沈阳军区总医院感染控制科；2. 210002江苏南京，南京军区南京总医院医务部；3. 110840辽宁沈阳，沈阳军区总医院/辽宁医学院研究生培养基地;4. 110840辽宁沈阳，沈阳军区总医院输血科
Author(s):
YANG Jing1; ZHAO Bin2; LI Xiao-hong3; YU Xiao-nan4.
1. Infection Control Department, General Hospital of Shenyang Military Command, Shenyang，Liaoning 110840, China; 2. Medical Administration Department, General Hospital of Nanjing Military Command, Nanjing, Jiangsu 210002, China; 3.Postgraduate Training Base of Liaoning Medical College, General Hospital of Shenyang Military Command, Shenyang，Liaoning 110840, China; 4.Department of Transfusion，General Hospital of Shenyang Military Command, Shenyang，Liaoning 110840, China
关键词:
颅内感染; 鲍曼不动杆菌; 耐药性; 危险因素
Keywords:
intracranial infection;  Acinetobacter baumannii;  drug resistance;  risk factors
分类号:
R117
DOI:
10.3969/j.issn.1672-271X.2016.03.003
文献标志码:
A
摘要:
目的 调查某院引起颅内感染细菌分布及造成感染的危险因素和危害性。方法 回顾性分析2012年10月-2015年10月某医院神经外科颅内感染患者送检的脑脊液标本的临床及微生物资料，统计病原菌分布及术后引起颅内细菌感染的危险因素。采用SPSS 19.0软件进行统计学分析。结果 3年间颅内感染患者分离出74株细菌，其中鲍曼不动杆菌43株，占58.1%；相对于其他细菌感染，鲍曼不动杆菌颅内感染的高危因素，单变量分析为肺炎、进行气管切开、气管插管、经外周静脉置入中心静脉导管及鼻饲；多变量分析的高危因素仅经外周静脉置入中心静脉导管及鼻饲。鲍曼不动杆菌引起的颅内感染，鼻饲、脑室引流和多重耐药菌株感染是导致患者死亡的危险因素。结论 鲍曼不动杆菌是当前引起颅脑手术患者颅内感染的最常见病原菌，且危害严重，针对颅内感染危险因素制定有效的感染控制措施，减少鲍曼不动杆菌引起的颅内感染是当务之急。
Abstract:
Objective To analyze the pathogens distribution and risk factors in the patients with craniotomy. Methods The clinical data were reviewed retrospectively for 74 patients with intracranial infection in the General Hospital of Shenyang Military Area Command from October 2012 to October 2015. The pathogen distribution and the risk factors caused intracranial infection were analyzed. All data were analyzed by SPSS 19.0 software. Results A total of 74 isolates were collected from the patients with craniotomy during 3 years, and the most frequent pathogen isolated bacterial was A.baumannii (58.1%). Single variable analysis showed pneumonia, tracheotomy, tracheal intubation, peripheral inserted central catheters, nasal feeding were the risk factors. Additionally, multivariate analysis showed that central venous catheter and nasal feeding were independently associated with A. Baumannii meningitis. The risk factors for the mortality and survival of A. Baumannii meningitis included external ventricular drainage, nasal feeding, multidrug-resistant A. Baumannii. Conclusion A.baumannii is the most frequent pathogens in intracranial infection after craniotomy. Relevant preventive measures should be strengthened to reduce the incidence of intracranial infection.

参考文献/References:

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备注/Memo

备注/Memo:
中华医院感染控制研究基金（ZHYY2015-0035）
更新日期/Last Update: 2016-05-20