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[1]陈昌浩,孙岳军,王建东.受体酪氨酸激酶EphB6蛋白在结直肠癌中表达及临床意义[J].医学研究与战创伤救治(原医学研究生学报),2016,18(04):346-348.[doi:10.3969/j.issn.1672-271X.2016.04.003]
　CHEN Chang-hao,SUN Yue-jun,WANG Jian-dong..Clinical significance of decreased expression of EphB6 receptor tyrosine kinase in colorectal carcinoma[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2016,18(04):346-348.[doi:10.3969/j.issn.1672-271X.2016.04.003]
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受体酪氨酸激酶EphB6蛋白在结直肠癌中表达及临床意义()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第18卷
期数:
2016年04期
页码:
346-348
栏目:
出版日期:
2016-08-20

文章信息/Info

Title:
Clinical significance of decreased expression of EphB6 receptor tyrosine kinase in colorectal carcinoma
作者:
陈昌浩1; 孙岳军2; 王建东3
1. 210003江苏南京，东南大学附属第二医院肝胆外科；2. 214400江苏江阴， 江阴市人民医院病理科；3. 210002江苏南京，南京军区南京总医院病理科
Author(s):
CHEN Chang-hao1;  SUN Yue-jun2;  WANG Jian-dong3.
1. The Second Affiliated Hospital of Southeast University, Nanjing, Jiangsu 210003, China; 2. Jiangyin Peoples Hospital, Jiangyin, Jiangsu 214400, China; 3. Nanjing General Hospital, Nanjing, Jiangsu 210002, China
关键词:
受体酪氨酸激酶; 肝细胞激酶受体B6; 结直肠癌
Keywords:
receptor tyrosine kinase;  EphB6;  colorectal carcinoma
分类号:
R365；R735.37
DOI:
10.3969/j.issn.1672-271X.2016.04.003
文献标志码:
A
摘要:
目的 探索促红细胞生成素产生肝细胞激酶受体B6（EphB6）蛋白在结直肠癌中表达及其临床意义。 方法 采用免疫组织化学染色方法检测一组结直肠癌组织中EphB6蛋白表达，分析其与临床 病理指标以及患者总生存时间之间的关系。结果 正常黏膜组织EphB6蛋白阳性表达率为75.0%（93/124），腺瘤型息肉为73.7%（42/57），结直肠癌组织中为54.0%（67/124）， EphB6在结直肠癌中的 表达显著低于腺瘤和正常黏膜（P＜0.05）。EphB6蛋白在癌组织中表达与肿瘤分化（P＜0.01）、淋巴结转移（P＜0.01）和Dukes分期（P＜0.01）有关；但与结直肠癌患者的年龄、性别和部位无关。 EphB6低表达患者比高表达患者预后差（P＜0.05）。结论 EphB6 在结直肠癌发生、发展和预后中可能具有抑癌基因的作用，可能成为一种新的肿瘤预后和治疗靶点。
Abstract:
Objective To explore the clinical significance of decreased expression of EphB6 receptor tyrosine kinase in colorectal carcinoma. Methods A set of colorectal carcinoma samples was detected the expression of EphB6 by using immunohistochemical staining. The relationship between the expression of EphB6 and clinicopathological parameters and survival was analyzed. Results The EphB6 expression was detected in normal mucosa (75.0%, 93/124), adenoma (73.7%, 42/57), colorectal carcinoma (54.0%, 67/124). The expression level of EphB6 was significantly decreased in colorectal cancer compared with adenoma and normal mucosa (P<0.05). The decreased expression of EphB6 was significantly associated with differentiation (P<0.01), lymph node metastasis(P<0.01) and Dukes stage (P<0.01). There was no significant difference between the expression of EphB6 and age, sex, and tumor location. The patients with decreased expression of EphB6 had a poor survival (P<0.05). Conclusion EphB6 may have a tumor suppressor role in colorectal carcinoma and may be a new target for therapy.

参考文献/References:

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备注/Memo

备注/Memo:
国家自然基金（81371611）
更新日期/Last Update: 2016-07-20