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[1]栾云,殷立平,黄辉,等.脉搏波速度技术对原发性高血压患者颈动脉弹性功能的初步探讨[J].医学研究与战创伤救治(原医学研究生学报),2016,18(05):451-454.[doi:10.3969/j.issn.1672-271X.2016.05.001]
　LUAN Yun,YIN Li-ping,HUANG Hui,et al.Studying carotid arterial stiffness of hypertension patients using PWV: a preliminary research[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2016,18(05):451-454.[doi:10.3969/j.issn.1672-271X.2016.05.001]
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脉搏波速度技术对原发性高血压患者颈动脉弹性功能的初步探讨()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第18卷
期数:
2016年05期
页码:
451-454
栏目:
出版日期:
2016-09-20

文章信息/Info

Title:
Studying carotid arterial stiffness of hypertension patients using PWV: a preliminary research
作者:
栾云; 殷立平; 黄辉; 张芹; 李宏波; 刘牛; 李惠玲; 吴琳琳; 何玉冰
210029江苏南京，南京中医药大学附属医院超声科
Author(s):
LUAN Yun;  YIN Li-ping;  HUANG Hui;  ZHANG Qin;  LI Hong-bo;  LIU Niu;  LI Hui-ling;  WU Lin-lin;  HE Yu-bing.
Department of Ultrasound, Affiliated Hospital of Nanjing University of TCM, Nanjing, Jiangsu 210029, China
关键词:
高血压; 脉搏波速度; 内膜中层厚度
Keywords:
hypertension;  pulse wave velocity (PWV); intima-media thickness (IMT)
分类号:
R445.1
DOI:
10.3969/j.issn.1672-271X.2016.05.001
文献标志码:
A
摘要:
目的 评价脉搏波速度（PWV）这一技术的稳定性和可重复性,研究颈动脉弹性和血压之间的相关性。方法 收集高血压72例，男31例，女41例，年龄17～85（62.76±12.17）岁。依据血压水平将入组的高血压患者分为三个亚组(1、2、3级组)。同时纳入26例非高血压受检者作为对照组，男10例，女16例，年龄41～76（59.65±8.12）岁。两位医生分别测得颈动脉内中膜厚度（IMT）、颈动脉PWV数值收缩期开始[PWV（BS）]、收缩期结束[PWV（ES）]，评价IMT、BS、ES数值的可重复性，同时比较定量参数（IMT、BS、ES）在组间（高血压组和对照组）及组内（高血压三个亚组）的差异性。结果 ①IMT、BS、ES数值的可重复性高。② 对照组与高血压组之间比较，三个变量（IMT、BS、ES）均存在组间统计学差异。高血压组组内（三个亚组间）比较:IMT，2级组与3级组无统计学意义；BS，1级组与2级组之间、2级组与3级组无统计学意义;ES，三个亚组间均有统计学意义（P<0.05）。 结论 PWV技术可重复性高，相对IMT，PWV能更敏感显示血管弹性和血压之间的相关性。
Abstract:
Objective To evaluate the stability and repeatability of pulse wave velocity (PWV), and study the correlation between the arterial stiffness and hypertension using PWV. Methods Seventy two cases of hypertensive patients (31 males and 41 females, average age 62.76±12.17 years) were included in this study. Based on the level of blood pressure, 72 hypertensive patients were divided into three subgroups. For comparative study, 26 cases of non-hypertensive subjects were enrolled as normal control group including 10 males and 16 females (average age 59.65±8.12 years). Carotid intima-media thickness (IMT) and carotid PWV value (BS, ES) were measured by two doctors separately. The repeatability of IMT, BS and ES value were evaluated using Bland-Altman plot. The difference of quantitative parameters (IMT, BS, ES) were studied both in between-group and the inter-group. Results ① There was high repeatability of IMT, BS, ES. ② Relative to IMT, there was significant difference of ES both in between-group and inter-group. Conclusion PWV measurement was reproducible method to determine arterial stiffness. PWV can be more sensitive to display the correlation between the arterial stiffness and hypertension.

参考文献/References:

[1]Ben-Shlomo Y, Spears M, Boustred C, et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects[J]. J Am Coll Cardiol, 2014, 63(7): 636-646.
[2]Calvet D, Touze E, Laurent S, et al. Aortic stiffness measurement improves the prediction of asymptomatic coronary artery disease in stroke/transient ischemic attack patients[J]. Int J Stroke, 2014, 9(3): 291-296.
[3]Karras A, Hayman JP, Bozec E, et al.Large artery stiffening and remodeling are independently associated with all-cause mortality and cardiovascular events in chronic kidney disease[J]. Hypertension, 2012, 60(6): 1451-1457.
[4]曹琴琴，张君，肖露露，等.高血压治疗与缺血性脑卒中严重程度相关性分析[J].医学研究生学报,2015,28（11）：1156-1159.
[5]Ochi N, Tabara Y, Igase M, et al. Silent cerebral microbleeds associated with arterial stiffness in an apparently healthy subject[J]. Hypertens Res, 2009, 32(4): 255-260.
[6]Laurent S, Boutouyrie P. Arterial stiffness: a new surrogate end point for cardiovascular disease? [J] J Nephrol, 2007, 20(suppl12): S45-S50.
[7]Lacolley P, Challande P, Osborne-Pellegrin M, et al.Genetics and pathophysiology of arterial stiffness [J]. Cardiovasc Res, 2009, 81(4): 637-648.
[8]吴金飞, 陈传琳, 曾素琴, 等. 脑梗死危险因素及生化特征分析[J]. 东南国防医药, 2014, 16(3): 270-272.
[9]叶任高, 陆再英. 内科学[M]. 6版. 北京:人民卫生出版社, 2004: 247．
[10]刘加美，覃思源，肖露露，等.高血压对缺血性卒中TOAST各亚型复发风险的影响[J].医学研究生学报,2014,27（10）：1052-1055.
[11]徐璐，高慧，邢光亮，等.1,25二羟维生素D3与高血压病的研究进展[J].医学研究生学报,2014,27（5）：527-530.
[12]王颖, 许德兵. 隐匿性高血压的研究进展[J]. 东南国防医药, 2013, 15(2):164-166.
[13]Eli Faury G．Function-structure relationship of elastic arteries in evolution：from micro fibrils to elastin and elastic fibres[J]．Pathol Biol(Paris), 2001, 49(4): 310-325．
[14]Safar ME, Temmar M, Kakou A, et al. Thornton SN Sodium intake and vascular stiffness in hypertensions[J]. Hypertension, 2009, 54(2): 203-209.
[15]Oberleithner H, Peters W, Kusche-Vihrog K, et al.Salt overload damages the glycocalyx sodium barrier of vascular endothelium[J]. Eur J Physiol, 2011, 462(4): 519-528.
[16]Oberleithner H, de Wardener HE.Sodium: a wolf in sheep’s clothing[J]. Blood Purif,2011, 31(1-3): 82-85.
[17]Herrera VL, Decano JL, Giordano N, et al. Aortic and carotid arterial stiffness and epigenetic regulator gene expression changes precede blood pressurerise in stroke-prone Dahl salt-sensitive hypertensive rats [J]. PLoS One, 2014, 9(9):e107888.
[18]Recio-Rodriguez JI, Gomez-Marcos MA, Patino-Alonso MC, et al. Abdominal obesity vs general obesity for identifying arterial stiffness, subclinical atherosclerosis and wave reflection in healthy, diabetics and hypertensive [J]. BMC Cardiovasc Disord, 2012, 12: doi:10.1186/1471-2261-12-3.
[19]Dudenbostel T, Glasser SP. Effects of antihypertensive drugs on arterial stiffness[J]. Cardiol Rev, 2012, 20(5): 259-263.
[20]黄伟俊, 陈颖瑜, 黄婷, 等. 高血压患者颈动脉弹性改变的初步观察及其ROC分析[J]. 实用医学杂志, 2014, 30(2): 281-283.
[21]中国医师协会超声医师分会.血管和浅表器官超声检查指南[M]. 北京:人民军医出版社, 2011:26.

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备注/Memo

备注/Memo:
国家中医临床研究基地业务建设第二批科研专项（JDZX2015104）
更新日期/Last Update: 2016-12-09