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[1]乐根明,朱燕,陈晨,等.食管癌放疗后局部淋巴结转移行伽马刀治疗联合化疗的疗效分析[J].医学研究与战创伤救治(原医学研究生学报),2017,19(03):268-271.[doi:10.3969/j.issn.1672-271X.2017.03.012]
　YUE Gen-ming,ZHU Yan,CHEN Chen,et al.Clinical analysis on the body gamma knife combined with chemotherapy foresophageal carcinoma complicated with loco-regional lymph node metastasis after radiotherapy[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2017,19(03):268-271.[doi:10.3969/j.issn.1672-271X.2017.03.012]
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食管癌放疗后局部淋巴结转移行伽马刀治疗联合化疗的疗效分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第19卷
期数:
2017年03期
页码:
268-271
栏目:
出版日期:
2017-05-20

文章信息/Info

Title:
Clinical analysis on the body gamma knife combined with chemotherapy foresophageal carcinoma complicated with loco-regional lymph node metastasis after radiotherapy
作者:
乐根明1; 朱燕2; 陈晨1; 张超南1; 朱伯进1
作者单位：1.224001盐城，南京中医药大学附属盐城市中医院肿瘤科；2.224200东台，东台市中医院肿瘤科
Author(s):
YUE Gen-ming1;  ZHU Yan2;  CHEN Chen1;  ZHANG Chao-nan1;  ZHU Bo-jin1
(1.Department of Oncology, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine, Yanchen 224001, Jiangsu, China;2.Department of Oncology, Dongtai Hospital of Traditional Chinese Medicine, Dongtai 224200, Jiangsu, China)
关键词:
食管癌; 化疗; 淋巴结转移; 伽马刀
Keywords:
Esophageal carcinoma;  Chemotherapy;  Lymph node metastasis;  Gamma knife therapy
分类号:
R735.1
DOI:
10.3969/j.issn.1672-271X.2017.03.012
文献标志码:
A
摘要:
目的 分析临床无远处转移食管鳞癌患者接受根治性放疗后出现锁骨上或纵隔淋巴结转移行伽马刀治疗联合化疗的疗效和相关不良反应。方法 回顾性分析经治的45例接受根治性放疗后出现锁骨上或纵隔淋巴结转移的食管鳞癌患者，分为联合组和对照组；2组均给予伽马刀治疗，联合组给予紫杉醇和奈达铂化疗。结果 联合组和对照组总有效率分别为90.9%和65.2%（P<0.05）；气管受侵或受压变形总缓解率分别为90.9%和50.0%（P<0.05），声音嘶哑、进食梗阻和疼痛总缓解率差异无统计学意义（P>0.05）；1年总生存率分别为86.4%和56.5%(P<0.05)，3年和5年后总生存率差异无统计学意义（P>0.05）；放射性食管炎和放射性肺炎发生率差异均无统计学意义（P>0.05），骨髓抑制发生率分别为72.7%和34.8%（P<0.05），消化道反应发生率分别为72.7%和39.1%（P<0.05）。结论 伽马刀治疗联合紫杉醇及奈达铂化疗能显著提高缓解率，缓解气管受侵或受压变形的症状，提高短期生存率，但在提高长期生存率方面无显著优势，有增加骨髓抑制和消化道反应的风险。
Abstract:
Objective To analyse the effects and adverse reactions of the body gamma knife combined with chemotherapy for esophageal carcinoma without of clinical distant metastasis complicated but with supraclavicular or mediastinal lymph node metastasis after radiotherapy.Methods 45 patients were divided into combined group and control group. Two groups were treated with the body gamma knife, and combined group were treated with paclitaxel and nedaplatin by intravenous injection.Results The short-term effective rates of combined group and control group were 90.9% and 65.2% respectively (P<0.05).The remission rates of tracheal invasion or compression were 90.9% and 50.0% (P<0.05).There was no statistical difference in remission rates of hoarse voice, eating obstruction and pain (P>0.05). The 1-year survival rates were 86.3% and 56.5% (P<0.05), but there was no statistical difference in 3-year and 5-year survival rates(P>0.05). There were no statistical differences in occurrence rates of radiation esophagitis and radiation pneumonitis(P>0.05). The occurrences rate of bone marrow suppression were 72.7% and 34.8% (P<0.05), and the occurrences of digestive tract reaction were 72.7% and 39.1% (P<0.05).Conclusion The body gamma knife combined with paclitaxel and nedaplatin can significantly improve short-term effective rate, remission rate of tracheal invasion or compression and 1-year survival rate,but cant improve long-term survival rate, moreover, it can increase the occurrence rate of bone marrow suppression and digestive tract reaction.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2017-05-20