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[1]洪丽君,曾清芳,卢昆林,等.高尔基体磷蛋白3在卵巢癌中的表达及临床意义[J].医学研究与战创伤救治(原医学研究生学报),2017,19(04):357-360.[doi:10.3969/j.issn.1672-271X.2017.04.006]
　HONG Li-jun,ZENG Qing-fang,LU Kun-lin,et al.Expression and clinical significance of Golgi phosphoprotein 3 in ovarian cancer[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2017,19(04):357-360.[doi:10.3969/j.issn.1672-271X.2017.04.006]
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高尔基体磷蛋白3在卵巢癌中的表达及临床意义()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第19卷
期数:
2017年04期
页码:
357-360
栏目:
出版日期:
2017-08-10

文章信息/Info

Title:
Expression and clinical significance of Golgi phosphoprotein 3 in ovarian cancer
作者:
洪丽君; 曾清芳; 卢昆林; 戴凤英
作者单位：362000泉州，解放军第180医院妇产科
Author(s):
HONG Li-jun;  ZENG Qing-fang; LU Kun-lin;  DAI Feng-ying
(Department of Obstetrics and Gynecology,the 180th Hospital of PLA, Quanzhou 362000,Fujian,China)
关键词:
卵巢癌; 高尔基体磷蛋白3; 免疫组化; 预后
Keywords:
Ovarian cancer;  Golgi phosphoprotein 3;  Immunohistochemistry;  Prognosis
分类号:
R737.31
DOI:
10.3969/j.issn.1672-271X.2017.04.006
文献标志码:
A
摘要:
目的 探讨高尔基体磷蛋白3（GOLPH3）在卵巢癌中的表达及其与卵巢癌的临床病理特征和预后的关系。方法 选取2007年1月至2012年1月在解放军第180医院行手术治疗的132例卵巢癌患者组织标本及80例卵巢良性肿瘤组织标本，用免疫组织化学法检测标本中GOLPH3的表达水平，并分析其表达量与卵巢癌临床病理参数的关系，同时采用Kaplan-Meier法分析GOLPH3的表达水平与患者生存时间的关系。结果 卵巢癌中GOLPH3的阳性表达率为72.7%，高于卵巢良性肿瘤（38.8%），差异有统计学意义（P＜0.05）。GOLPH3在Ⅲ期和Ⅳ期卵巢癌患者中的表达显著高于Ⅰ期和Ⅱ期患者，在高分化患者中的表达显著低于中低分化患者（P＜0.05），而与年龄及有无淋巴结转移无关(P＞0.05)。生存曲线显示GOLPH3低表达患者与高表达患者相比总生存期更长（P＜0.05）。结论 GOLPH3在卵巢癌中高表达，其高表达可能提示肿瘤恶性程度高，患者生存时间短、预后差。
Abstract:
Objective To investigate the expression level and clinical significance of Golgi phosphoprotein 3 (GOLPH3) in ovarian cancer.Methods Make a retrospective study of 132 patients with ovarian cancer and 80 patients with benign ovarian tumor, who were surgically treated in our hospital between January 2007 and January 2012. Expressions of GOLPH3 were detected in their tissue specimens by immunohistochemistry. The association of GOLPH3 expression with clinicopathologic parameters and overall survival of ovarian cancer was analyzed.Results The positive expression rate of ovarian cancer (72.7%) was higher than that of benign ovarian tumor (38.8%), the difference was statistically significant (P＜0.05). In ovarian cancer, the expression of GOLPH3 was related with FIGO stage and pathologic grade with statistical significance (P＜0.05). The expression of GOLPH3 in stage Ⅲ and Ⅳ was significantly higher than that in stage Ⅰ and Ⅱ patients, and the expression of patients with high differentiation was significantly lower than that of patients with low differentiation (P＜0.05). However, it was not related with age and lymph node metastasis (P＞0.05). Survival curve showed that low GOLPH3 expression levels were associated with significantly longer overall survival than high expression levels (P＜0.05).Conclusion The expression of GOLPH3 was up-regulated in ovarian cancer, which was correlated with less differentiation, shorter survival time and poor prognosis.

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备注/Memo

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更新日期/Last Update: 2017-07-20