|本期目录/Table of Contents|

[1]朱明武,徐国超,李姗姗综述,等.人类白细胞抗原G基因多态性在临床疾病中的意义[J].医学研究与战创伤救治(原医学研究生学报),2018,20(01):57-61.[doi:10.3969/j.issn.1672-271X.2018.01.013]
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人类白细胞抗原G基因多态性在临床疾病中的意义()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第20卷
期数:
2018年01期
页码:
57-61
栏目:
综述
出版日期:
2018-01-22

文章信息/Info

Title:
-
作者:
朱明武; 徐国超; 李姗姗综述; 朱明文审校
作者单位：453100卫辉,新乡医学院第一附属医院检验科(朱明武);453000新乡,新乡市中心医院检验科(徐国超);453000新乡,新乡市第二人民医院检验科(李姗姗)；453000 新乡，新乡医学院第二附属医院营养科(朱明文)
Author(s):
-
关键词:
炎症; 感染; 自身免疫疾病; 人类白细胞抗原
Keywords:
-
分类号:
R392.32
DOI:
10.3969/j.issn.1672-271X.2018.01.013
文献标志码:
A
摘要:
人类白细胞抗原G(HLA-G)基因最早在人类胎盘组织中发现，主要分布于怀孕期间母胎界面绒毛外细胞滋养层细胞上，是一类属于非经典白细胞I类抗原分子，又称HLAⅠb。与经典的HLA分子相比不仅分布具有限制性，其多态性也+分有限。HLA-G多态性主要存在于3′非翻译区（3′-untranslated region，3′UTR）和5′上游调控区(5′-upstream regulation region，5′URR)，这些多态性位点与自身免疫性疾病、病毒感染和肿瘤有着强烈的关联性。文章主要对HLA-G多态性位点与自身免疫疾病、肿瘤、病毒感染等临床疾病的相关性进行综述。
Abstract:
-

参考文献/References:

[1]朱明武, 程瑞, 李威. HLA-G 非编码区单核苷酸多态性与不明原因反复流产的相关[J]. 免疫学杂志, 2017, 33(3): 239-244.[2]王小红, 王军青, 王志君, 等. HLA-G 在子痫前期患者与正常妊娠胎盘中的差异表达[J]. 东南国防医药, 2010, 12(1): 18-20.[3]陈哲, 胡明道, 田大广,等. 重组腺病毒介导人类白细胞抗原-G基因转染恒河猴树突状细胞对T细胞的增殖作用[J]. 医学研究生学报, 2017, 30(1):5-9.[4]Catamo E, Zupin L, Segat L, et al.HLA-G and susceptibility to develop celiac disease.[J]. Hum Immunol, 2015, 76(1):36-41.[5]Zelante A, Borgoni R, Galuppi C,et al. Therapy modifies HLA-G secretion differently in Crohn’s disease and ulcerative colitis patients[J]. Inflamm Bowel Dis, 2011, 17(8): E94-E95.[6]Zidi I, Ben YH, Bortolotti D, et al. Association between sHLA-G and HLA-G 14-bp deletion/insertion polymorphism in Crohn’s disease[J]. Int Immunol, 2015, 27(6):289.[7]庞春艳, 王永福. 微小RNA在类风湿关节炎诊断和治疗中的作用[J]. 医学研究生学报, 2014, 27(5):554-556.[8]Veit TD, de Lima CPS, Cavalheiro LC, et al. HLA-G+ 3142 polymorphism as a susceptibility marker in two rheumatoid arthritis populations in Brazil[J]. HLA, 2014, 83(4): 260-266.[9]Mariaselvam CM, Chaaben AB, Salah S, et al. Human leukocyte antigen-G polymorphism influences the age of onset and autoantibody status in rheumatoid arthritis[J].HLA, 2015, 85(3): 182-189.[10]Rizzo R, Rubini M, Govoni M,et al. HLA-G 14-bp polymorphism regulates the methotrexate response in rheumatoid arthritis[J]. Pharmacogenet Genom, 2006, 16(9): 615-623.[11]Rajasekaran A, Shivakumar V, Kalmady SV,et al. The impact of HLA-G 3′ UTR variants and sHLA-G on risk and clinical correlates of schizophrenia[J]. Hum Immunol, 2016, 77(12): 1166-1171.[12]Rajasekaran A, Shivakumar V, Kalmady SV, et al. Soluble human leukocyte antigen (sHLA)-G levels may predict early onset of schizophrenia in male patients[J].HLA, 2016, 86(1):36-37.[13]Bortolotti D, Gentili V, Rotola A, et al. Impact ofHLA-G analysis in prevention, diagnosis and treatment of pathological conditions[J]. World J Meth, 2014, 4(1): 11.[14]Mohammadi N, Adib M, Alsahebfosoul F, et al. An investigation into the association between HLA-G 14bp insertion/deletion polymorphism and multiple sclerosis susceptibility[J]. J Neuroimmunol, 2016, 290: 115-118.[15]Fredj NB, Sakly K, Bortolotti D,et al. The association between functional HLA-G 14bp insertion/deletion and+ 3142 C> G polymorphisms and susceptibility to multiple sclerosis[J]. Immunol Lett, 2016, 180: 24-30.[16]Crespo C, van der Zwan A, Ramalho-Santos J,et al. Cytotoxic potential of decidual NK cells and CD8+ T cells awakened by infections[J]. J Reprod Immunol, 2016.[17]Viganò S, Negrón JJ, Tse S,et al. HLA-G+ HIV-1-specific CD8+ T cells are associated with HIV-1 immune control[J]. Aids, 2017, 31(2): 207-212.[18]Li C, Toth I, zur Wiesch JS,et al. Functional characterization of HLA-G+ regulatory T cells in HIV-1 infection[J]. PLoS Pathog, 2013, 9(1): e1003140.[19]Segat L, Zupin L, Kim HY,et al. HLA-G 14 bp deletion/insertion polymorphism and mother-to-child transmission of HIV[J]. HLA, 2014, 83(3): 161-167.[20]Xu HH, Shi WW, Lin A,et al. HLA-G 3′ untranslated region polymorphisms influence the susceptibility for human papillomavirus infection[J]. HLA, 2014, 84(2): 216-222.[21]Metcalfe S, Roger M, Faucher MC,et al. The association between human leukocyte antigen (HLA)-G polymorphisms and human papillomavirus (HPV) infection in Inuit women of northern Quebec[J]. Hum Immunol, 2013, 74(12): 1610-1615.[22]Boukouaci W, Busson M, Fortier C, et al. Association ofHLA-G low expressor genotype with severe acute graft-versus-host disease after sibling bone marrow transplantation[J]. Front Immuno, 2011, 2.[23]Liu H, Chen Y, Xuan L, et al.Soluble human leukocyte antigen G molecule expression in allogeneic hematopoietic stem cell transplantation: good predictor of acute graft-versus-host disease[J]. Acta haematol, 2013, 130(3): 160-168.[24]Waterhouse M, Duque-Afonso J, Wsch R, et al. SolubleHLA-G molecules and HLA-G 14-base pair polymorphism after allogeneic hematopoietic cell transplantation[J]. Transpl P, 2013, 45(1):397-401.[25]王子越, 王芳. HLA-G在子宫内膜中表达情况与其相关疾病的研究进展[J]. 包头医学院学报, 2017, 33(3):131-132.[26]Mach P, Blecharz P, Basta P, et al.Differences in the Soluble HLA-G Blood Serum Concentration Levels in Patients with Ovarian Cancer and Ovarian and Deep Endometriosis[J]. Am J Reprod Immunol, 2010, 63(5): 387-395.[27]Donadi EA, Castelli EC, Arnaiz-Villena A, et al. Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association[J]. Cell Mol Life Sci, 2011, 68(3): 369-395.[28]Rouas-Freiss N, Moreau P, Ferrone S, et al.HLA-G proteins in cancer: do they provide tumor cells with an escape mechanism?[J]. Cancer Res, 2005, 65(22): 10139-10144.[29]Li T, Huang HH, Liao D, et al. Genetic polymorphism in HLA - G, 3′UTR 14-bp ins/del and risk of cancer: a meta-analysis of case-control study[J]. Mol Genet Genom, 2015, 290(4):1235-1245.[30]Yang YC,Chang TY,Chen TC,et al. Human leucocyte antigen-G polymorphisms are associated with cervical squamous cell carcinoma risk in Taiwanese women[J], Eur J Cancer，2014, 50(2):469-474.[31]Bortolotti D, Gentili V, Rotola A, et al. Implication of HLA-G 3′ untranslated region polymorphisms in human papillomavirus infection[J]. HLA, 2014, 83(2): 113-118.[32]Rajasekaran A, Shivakumar V, Kalmady SV,et al. The impact of HLA-G 3′ UTR variants and sHLA-G on risk and clinical correlates of schizophrenia[J]. Hum Immunol, 2016, 77(12): 1166-1171.[33]Xu HH, Shi WW, Lin A,et al. HLA-G 3′ untranslated region polymorphisms influence the susceptibility for human papillomavirus infection[J]. HLA, 2014, 84(2): 216-222.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2018-01-20