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[1]徐杨,丛壮壮,冀赛光,等.C-反应蛋白与清蛋白比值对微创食管癌术后并发症的早期预测价值[J].医学研究与战创伤救治(原医学研究生学报),2018,20(04):371-375.[doi:10.3969/j.issn.1672-271X.2018.04.010]
　XU Yang,CONG Zhuang-zhuang,JI Sai-guang,et al.Predictive value of the postoperative ratio of C-reactive protein to albumin for complications afterminimally invasive esophageal surgery[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2018,20(04):371-375.[doi:10.3969/j.issn.1672-271X.2018.04.010]
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C-反应蛋白与清蛋白比值对微创食管癌术后并发症的早期预测价值()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第20卷
期数:
2018年04期
页码:
371-375
栏目:
临床研究
出版日期:
2018-07-20

文章信息/Info

Title:
Predictive value of the postoperative ratio of C-reactive protein to albumin for complications afterminimally invasive esophageal surgery
作者:
徐杨; 丛壮壮; 冀赛光; 邵晨烨; 胡力文; 强勇; 申翼
作者单位：210002 南京，南京军区南京总医院心胸外科[徐杨（医学硕士研究生）、丛壮壮、冀赛光、邵晨烨、胡力文、强勇、申翼]
Author(s):
XU Yang;  CONG Zhuang-zhuang;  JI Sai-guang;  SHAO Chen-ye;  HU Li-wen;  QIANG Yong;  SHEN Yi
(Department of Cardiothoracic Surgery, Nanjing General Hospital of Nanjing Military Region, PLA, Nanjing 210002, Jiangsu, China)
关键词:
C-反应蛋白与清蛋白比值; 微创食管癌手术; 术后并发症; 早期预测; 加速康复外科
Keywords:
C-reactive protein to albumin ratio; minimally invasive esophageal surgery; postoperative complications; early prediction; enhanced recovery after surgery
分类号:
R735.1
DOI:
10.3969/j.issn.1672-271X.2018.04.010
文献标志码:
A
摘要:
目的 C-反应蛋白与清蛋白比值（CAR）与肿瘤患者的临床预后相关，但微创食管癌术后CAR与并发症的关系尚未明确。文中对CAR在微创食管癌术后早期预测并发症的价值进行评估。方法 回顾性分析2014年9月至2017年10月在南京军区南京总医院心胸外科择期行微创食管癌手术的患者，共有209例患者入组。应用单因素和多因素分析被用于鉴别术后并发症的危险因素。绘制受试者工作特征（ROC）曲线确立CAR和CRP的截断值并比较两者在术后早期预测并发症的灵敏度、特异度和阳性预测值等。结果 209例中有55例（26.3%）患
Abstract:
Objective The ratio of C-reactive protein to albumin (CAR) is associated with clinical outcomes in cancer patients. However, the relationship between CRP/albumin ratio and postoperative complications in minimally invasive esophageal surgery is still unclear. We hypothesize the predictive value of CAR in minimally invasive esophageal surgery for postoperative complications.Methods A total of 209 patients undergoing minimally invasive esophageal surgery in Nanjing General Hospital of Nanjing Military Region between 2014 and 2017 were eligible for this study. The risk factors for postoperative complications were statistic analyzed by using univariate and multivariate analyses. Receiver operating characteristic (ROC) curves were utilized to figure out the cutoff values of CAR and postoperative C-reactive protein (CRP) levels and predictive value indexes, including sensitivity, specificity and positive predictive value.Results Fifty-five (26.3%) cases of 209 patients were diagnosed with postoperative complications. CAR was an independent risk factor for complications (OR 6.522；95% CI 2.247-18.934；P＜0001). ROC curve analysis revealed that the area under the curve of CAR was higher than that of CRP on postoperative day 3 (0841 vs 0776). The cutoff value of CAR was 4.1. The sensitivity, specificity, especially positive predictive value of CAR was higher than those of CRP on postoperative day 3. Patients with CAR≥4.1 were suffered more postoperative complications (702% vs 9.9%，P＜0001) and longer postoperative stays [(15.9±100) days vs (11.4±7.1) days，P=0002 ] than those with CAR＜4.1.Conclusion The ratio of C-reactive protein to albumin could lead to identify patients with a high probability of postoperative complications. The ratio was higher predictive value than C-reactive protein alone for postoperative complications in minimally invasive esophageal surgery. CAR could be utilized for the early detection and treatments of postoperative complications, subsequently guiding to enhanced recovery after surgery.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金（81172032）；江苏省自然科学基金（BK20160606）
更新日期/Last Update: 2018-07-20