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[1]段靖,周燕萍,杨辉,等.不同粒径地塞米松纳米混悬剂的体外透皮行为比较研究[J].医学研究与战创伤救治(原医学研究生学报),2019,21(3):273-276.[doi:10.3969/j.issn.1672-271X.2019.03.011]
　DUAN Jing,ZHOU Yan-ping,YANG Hui,et al.Comparative study on in vitro transdermal behavior of dexamethasone nanosuspensions with different particle sizes[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2019,21(3):273-276.[doi:10.3969/j.issn.1672-271X.2019.03.011]
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不同粒径地塞米松纳米混悬剂的体外透皮行为比较研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第21卷
期数:
2019年3期
页码:
273-276
栏目:
出版日期:
2019-05-10

文章信息/Info

Title:
Comparative study on in vitro transdermal behavior of dexamethasone nanosuspensions with different particle sizes
文章编号:
1672-271X（2019）03-0273-04
作者:
段靖;  周燕萍;  杨辉;  鲁毅;  王亚威;  姜漫;  许桂丽
作者单位：210002 南京，东部战区空军医院药剂科（段 靖、周燕萍、鲁 毅、王亚威、姜 漫、许桂丽），信息科（杨 辉）
Author(s):
DUAN Jing;  ZHOU Yan-ping;  YANG Hui;  LU Yi;  WANG Ya-wei;  JIANG Man;  XU Gui-li
(Department of Pharmacy， Air Force Hospital of Eastern Theater Command, Nanjing 210002, Jiangsu, China)
关键词:
地塞米松;  纳米混悬剂;  粒径;  体外透皮行为;  皮肤滞留
Keywords:
dexamethasone;  nanosuspension;  particle size;  transdermal behavior;  skin retention
分类号:
R944.1
DOI:
10.3969/j.issn.1672-271X.2019.03.011
文献标志码:
A
摘要:
目的 比较不同粒径地塞米松纳米混悬剂（Dex-NS）的体外透皮行为，探讨粒径对Dex-NS经皮渗透性和皮肤滞留的影响。 方法 采用介质研磨法，通过控制不同工艺参数制备3种不同粒径的Dex-NS，扫描电镜观察形态，Franze扩散池法比较不同粒径Dex-NS的体外透皮行为。 结果 成功制备了3种不同粒径的Dex-NS，分别为Dex-NS200（199 nm）、Dex-NS500（491 nm）、Dex-NS800（810 nm）；扫描电镜（SEM）结果显示Dex-NS200存在颗粒状和棒状两种结构，Dex-NS500呈棒状结构，Dex-NS800为短棒状结构；体外透皮实验结果显示，不同粒径Dex-NS的24 h体外经皮累积透过量（Qt）顺序为：Dex-NS200（23.61 ?g/cm2）>Dex-NS500（17.37 ?g/cm2）>Dex-NS800（11.64 ?g/cm2），皮肤滞留量顺序为：Dex-NS500（18.24 ?g/cm2）>Dex-NS200（14.27 ?g/cm2）>Dex-NS800（9.46 ?g/cm2）。 结论 粒径对Dex-NS的体外透皮行为有显著影响，500 nm左右的Dex-NS的皮肤滞留量相对较高，适宜局部应用。
Abstract:
Objective To compare the in vitro transdermal behaviors of dexamethasone nanosuspension (Dex-NS) with three particle sizes and explore the influence of particle sizes on skin permeation and retention of Dex-NS. Methods Dex-NSs with three different particle sizes were prepared using media milling by adjusting process parameters. Their morphologies were observed by scanning electron microscope (SEM). The in vitro transdermal behaviors of Dex-NS with different particle sizes were compared by Franz diffusion cells. Results Dex-NSs with three different particle sizes, Dex-NS200 (199 nm), Dex-NS500 (491 nm) and Dex-NS800 (810 nm) were successfully prepared. SEM showed Dex-NS200 existed two structures of granular and rod-shaped. Dex-NS500 was rod-like in shape. And Dex-NS800 had a short rod-like structure. In vitro transdermal experiments gave the cumulative amount of drug penetrated (Qt) of Dex-NSs with three different particle size in an order of Dex-NS200 (23.61 ?g/cm2)>Dex-NS500 (17.37 ?g/cm2)>Dex-NS800 (11.64 ?g/cm2) and skin retention in an order of Dex-NS500 (18.24 ?g/cm2)>Dex-NS200 (14.27 ?g/cm2)>Dex-NS800 (9.46 ?g/cm2). Conclusion The particle size has significant effect on in vitro transdermal behavior of Dex-NSs and Dex-NS with particle size around 500 nm，possessing higher skin deposition and being suitable for topical application.

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备注/Memo

备注/Memo:
收稿日期：2018-11-29
更新日期/Last Update: 2019-05-10