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[1]林妹珠,倪清丽综述,黄惠娟审校.PM2.5通过ER/RANK通路调节骨代谢的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2020,22(2):178-182.[doi:10.3969/j.issn.1672-271X.2020.02.014]
　LIN Mei zhu,NI Qing li reviewing,HUANG Hui juan checking.Study on the regulation of bone metabolism by PM2.5 through ER/RANK pathway[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2020,22(2):178-182.[doi:10.3969/j.issn.1672-271X.2020.02.014]
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PM2.5通过ER/RANK通路调节骨代谢的研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第22卷
期数:
2020年2期
页码:
178-182
栏目:
综述
出版日期:
2020-03-11

文章信息/Info

Title:
Study on the regulation of bone metabolism by PM2.5 through ER/RANK pathway
作者:
林妹珠; 倪清丽综述; 黄惠娟审校
作者单位：350025 福州，福建医科大学福总临床医学院妇产科（林妹珠、倪清丽、黄惠娟）
Author(s):
LIN Meizhu;  NI Qingli reviewing;  HUANG Huijuan checking
(Department Obstetrics and Gynecology,Fuzhou Clinical Medical College,Fujian Medical University,Fuzhou 350025, Fujian, China)
关键词:
ER/RANK通路; PM2.5; 骨代谢
Keywords:
ER/RANK pathway;  PM2.5;  bone metabolism
分类号:
R681
DOI:
10.3969/j.issn.1672-271X.2020.02.014
文献标志码:
A
摘要:
OPGRANKLRANK系统是影响骨重建平衡的关键信号通路，雌激素水平改变，可通过ER/RANK途径影响破骨细胞的形成和骨吸收活性，进而影响骨代谢平衡。PM2.5是大气污染中的关键细颗粒物，表面积大，可捕获许多不同化合物来活化多环芳烃受体，直接或者间接影响骨细胞雌激素受体的促转录活性、干扰类固醇激素信号，使雌激素受体（ER）与雌二醇结合降低，进而引起一系列的骨代谢相关疾病。文章主要就PM2.5影响骨代谢与ER/RANK通路的相关性进行综述。
Abstract:
OPGRANKLRANK system is the key signal pathway that affects the balance of bone remodeling. The change of estrogen level can affect osteoclast formation and bone resorption activity through ER/RANK pathway, and then affect the balance of bone metabolism. PM2.5 is a key fine particle in air pollution with large surface area, which can capture many different compounds to activate polycyclic aromatic hydrocarbon receptors, directly or indirectly affect the transcriptional activity of estrogen receptors in osteocytes, interfere with steroid signals, reduce the binding of estrogen receptor (ER) to estradiol, and then cause a series of bone metabolismrelated diseases. This article mainly reviews the relationship between the effect of PM2.5 on bone metabolism and ER/RANK pathway.

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相似文献/References:

[1]曾小娟,杨帆综述,黄惠娟审校.PM2.5对绝经后骨质疏松症的影响研究进展[J].医学研究与战创伤救治(原医学研究生学报),2018,20(05):523.[doi:10.3969/j.issn.1672-271X.2018.05.017]

备注/Memo

备注/Memo:
基金项目：国家自然科学基金（81771547）
更新日期/Last Update: 2020-03-11