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[1]包芳,杨林东,吴元赭.早产及胎膜早破孕妇血清晚期糖基化终末产物水平分析[J].医学研究与战创伤救治(原医学研究生学报),2020,22(4):372-375.[doi:10.3969/j.issn.1672-271X.2020.04.008]
　BAO Fang,YANG Lin-dong,WU Yuan-zhe.Analysis of serum advanced glycation end products in pregnancies complicated by premature birth and premature rupture of membranes[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2020,22(4):372-375.[doi:10.3969/j.issn.1672-271X.2020.04.008]
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早产及胎膜早破孕妇血清晚期糖基化终末产物水平分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第22卷
期数:
2020年4期
页码:
372-375
栏目:
临床研究
出版日期:
2020-07-20

文章信息/Info

Title:
Analysis of serum advanced glycation end products in pregnancies complicated by premature birth and premature rupture of membranes
作者:
包芳; 杨林东; 吴元赭
作者单位：210002 南京，南京医科大学金陵临床医学院（东部战区总医院）妇产科（包芳、杨林东、吴元赭）
Author(s):
BAO Fang; YANG Lin-dong; WU Yuan-zhe
（Department of Obstetrics and Gynecology，Jingling Hospital，Nanjing Medical University/General Hospital of Eastern Theater Command，PLA，Nanjing 210002，Jiangsu，China）
关键词:
晚期糖基化终末产物; 早产; 胎膜早破
Keywords:
advanced glycation end products; premature delivery; premature rupture of membranes
分类号:
R714.7
DOI:
10.3969/j.issn.1672-271X.2020.04.008
文献标志码:
A
摘要:
目的探讨晚期糖基化终末产物（AGEs）在早产及胎膜早破（PROM）孕妇血清中的水平变化及意义。方法回顾性分析2018年1月-12月在东部战区总医院产科建卡按期产检且发生早产的孕妇20例（早产组）的临床资料，并匹配同期足月分娩的孕妇43例作为对照（足月组）。统计所有孕妇24周、32周和足月产孕妇37周时检测的血清AGEs水平，比较不同孕周同一人群和同一孕周不同人员的AGEs水平。并按是否发生胎膜早破，比较2组中胎膜早破孕妇和非胎膜早破孕妇不同孕周的AGEs水平。结果早产组孕妇年龄较足月组大[（32.05±4.75）岁vs（29.35±4.34）岁，P＜0.05]。早产组和足月组孕妇24周时的血清AGEs水平[(14.53±2.13)μg/mL、(8.65±2.94)μg/mL]均高于32周[ (10.83±2.03)μg/mL、(5.54±2.17)μg/mL]，差异有统计学意义（P＜0.01）。足月组37周血清AGEs水平[（7.91±2.97）μg/mL]明显高于32周（P＜0.01），与24周比较差异无统计学意义（P＞0.05）。早产组孕妇24周和32周时血清AGEs水平较足月组均明显增高（P＜0.01）。早产组中胎膜早破孕妇24周及32周血清AGEs水平与非胎膜早破孕妇比较差异均无统计学意义（P＞0.05）；足月组中胎膜早破孕妇24周、32周、37周血清AGEs水平[(12.07±3.28)μg/mL、(7.49±2.20)μg/mL、(10.77±3.16)μg/mL]较非胎膜早破孕妇[(8.10±2.51)μg/mL、(5.22±2.02)μg/mL、(5.22±2.02)μg/mL]均显著增高（P＜0.05）。结论孕妇血清AGEs水平随着孕周的增长呈下降趋势，在37周时又升高达一高峰，可能与足月分娩发动相关。血清AGEs水平的升高可能与早产及胎膜早破的发生有关。
Abstract:
Objective To investigate the change and significance of advanced glycation end products (AGEs) in serum of pregnant women with premature delivery and premature rupture of membranes (PROM).MethodsTwenty pregnant women with premature birth and regular check-ups (preterm group) and 43 pregnant women who were born at term during the same period as controls (full-term group) at the Eastern Military Theater General Hospital from January 2018 to December 2018 were included in the study . Serum AGEs were measured in all pregnant women at 24 weeks, 32 weeks, and 37 weeks of full-term pregnant women. The levels of AGEs in the same population at different gestation weeks and different persons in the same gestation week were compared. The preterm group and the term group were divided into two subgroups according to items whether premature rupture of membranes occurred, and the levels of AGEs in different gestational weeks were compared between two groups of pregnant women. Results The pregnant women in the preterm group were significantly older than the full-term group (32.05±4.75 vs 29.35±4.34, P＜0.05）. The serum AGEs of preterm and full-term pregnant women at 24 weeks [(14.53±2.13)μg/mL, (8.65±2.94)μg/mL] were higher than that at 32 weeks [(10.83±2.03)μg/mL, (5.54±2.17)μg/mL] (P<0.01). The serum AGEs level in the full-term group at 37 weeks [（7.91±2.97）μg/mL] was significantly higher than that at 32 weeks (P<0.01)，and there was no significant difference compared with 24 weeks (P>0.05). At 24 and 32 weeks of gestation, serum AGEs in the preterm group were significantly higher than those in the full-term group (P<0.01). There was no significant difference in AGEs levels between the PROM subgroup and the non-PROM subgroup in the preterm group (P>0.05). The serum AGEs levels of the pregnant women in the PROM subgroup [(12.07±3.28)μg/mL，(7.49±2.20)μg/mL，(10.77±3.16)μg/mL] in the term group were significantly higher than that in the non-PROM subgroup [(8.10±2.51)μg/mL，(5.22±2.02)μg/mL，(5.22±2.02)μg/mL] (P<0.05).ConclusionThe levels of serum AGEs of pregnant women showed a downward trend with the increase of gestational week with a peak at 37 weeks，which may be related to the initiation of full-term delivery. Increased serum AGEs may lead to the occurrence of preterm birth and premature rupture of membranes.

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更新日期/Last Update: 2020-07-13