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[1]曹林,陈晓良,李倩.18F-FDG PET/CT最大标准摄取值与局部晚期乳腺癌临床病理特征及预后的相关性[J].医学研究与战创伤救治(原医学研究生学报),2021,23(01):28-31.[doi:10.3969/j.issn.1672-271X.2021.01.001]
　CAO Lin,CHEN Xiao-liang,LI Qian.18F-FDG PET/CT SUVmax and clinicopathological features of locally advanced breast cancer and its correlation with prognosis[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(01):28-31.[doi:10.3969/j.issn.1672-271X.2021.01.001]
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18F-FDG PET/CT最大标准摄取值与局部晚期乳腺癌临床病理特征及预后的相关性()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第23卷
期数:
2021年01期
页码:
28-31
栏目:
临床研究
出版日期:
2021-01-20

文章信息/Info

Title:
18F-FDG PET/CT SUVmax and clinicopathological features of locally advanced breast cancer and its correlation with prognosis
作者:
曹林; 陈晓良; 李倩
作者单位：400030重庆，重庆大学附属肿瘤医院核医学科（曹林、陈晓良）；400030重庆，重庆大学附属中心医院/重庆市急救医疗中心核医学科（李倩）
Author(s):
CAO Lin1; CHEN Xiao-liang1; LI Qian2
(1.Department of Nuclear Medicine, Chongqing University Cancer Hospital, Chongqing 400030,China; 2.Department of Nuclear Medicine, Chongqing University Central Hospital/Chongqing Emergency Medical Center, Chongqing 400030, China)
关键词:
18F-脱氧葡萄糖; 正电子发射计算机断层扫描; 局部晚期乳腺癌; 病理特征; 预后
Keywords:
18F-fluorodeoxy glucose;  positron emission tomograpgy/computed tomography;  local advanced breast cancer;  pathological features;  prognosis
分类号:
R737.9
DOI:
10.3969/j.issn.1672-271X.2021.01.001
文献标志码:
A
摘要:
目的探讨18F-脱氧葡萄糖（18F-FDG）正电子发射计算机断层扫描（PET/CT）最大标准摄取值（SUVmax）与局部晚期乳腺癌（LABC）临床病理特征及预后的相关性。方法选取2017年7月至2019年10月收治的154例LABC患者，均行18F-FDG PET/CT检查，比较不同病理特征及预后患者SUVmax，分析SUVmax预测患者预后的价值。 结果肿瘤最大径≥3 cm、组织学分级低分化、T分期T3~T4、Ki-67≥14%、淋巴结转移者，其SUVmax高于肿瘤最大径＜3 cm、组织学分级中高分化、T分期T1~T2、Ki-67＜14%、无淋巴结转移者（P＜0.05）。化疗效果无效者SUVmax(4.13±0.95)低于有效者(5.54±1.34)，未完全缓解者SUVmax(4.57±1.12)亦低于完全缓解者(5.70±1.39)，差异均有统计学意义（P＜0.05）。SUVmax≥4.87组无事件生存率低于SUVmax＜4.87组，差异有统计学意义（P＜0.05）。Cox回归分析示，肿瘤最大径≥3 cm、组织学分级低分化、T分期T3~T4、Ki-67≥14%、淋巴结转移、SUVmax≥4.87是影响LABC患者预后的危险因素（P＜0.05）。结论18F-FDG PET/CT SUVmax与LABC肿瘤最大径、组织学分级、T分期、Ki-67及淋巴结转移有关，随着SUVmax的升高，患者对化疗的反应增强，但术后无事件生存期更短。
Abstract:
ObjectiveTo study the maximum standard uptake value (SUVmax) of 18F-fluorodeoxy glucose (18F-FDG) Positron emission tomograpgy/computed tomography (PET/CT) and local advanced breast cancer (LABC), and to explore the clinicopathological characteristics of cancer and the correlation with prognosis.MethodsA tatal of 154 LABC cases admitted from July 2017 to October 2019 were examined by 18F-FDG PET/CT. SUVmax was compared with different pathological features and prognosis, and the prognostic value of SUVmax was analyzed.ResultsThe SUVmax of patients with tumor maximum diameter ≥ 3 cm, low differentiation of histological grade, T stage T3-T4, Ki-67≥14%, lymph node metastasis was higher than that of patients with tumor maximumdiameter < 3 cm, high differentiation of histological grade, T stage T1-T2, Ki-67 < 14%, no lymph node metastasis (P<0.05).The SUVmax of ineffective patients (4.13±0.95) was lower than that of effective patients (5.54±1.34) (P<0.05). The SUVmax (4.57±1.12) of incomplete remission was also lower than that of complete remission (5.70±1.39) (P<0.05). The mean value of SUVmax of 154 patients with LABC was 4.87. The patients were included into SUVmax ≥4.87 group (n=77), SUVmax < 4.87 group (n=77), and the event-free survival rate of SUVmax ≥4.87 group was lower than that of SUVmax < 4.87 group (P<0.05). Cox regression analysis showed that the risk factors (P<0.05) for the prognosis of patients with LABC were tumor diameter ≥3 cm, histological grade low differentiation, T stage T3-T4, Ki-67≥14%, lymph node metastasis, SUVmax ≥4.87.Conclusion18F-FDG PET/CT SUVmax is associated with the largest diameter, histological grade, T-stage, Ki-67 and lymph node metastasis of LABC. With the increase of SUVmax, the response of patients to chemotherapy is enhanced, but the postoperative event-free survival period is shorter.

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备注/Memo

备注/Memo:
基金项目：重庆市科学技术委员会自然科学基金（cstc2018jcyjAX0819）
更新日期/Last Update: 2021-01-26