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[1]宋晓东,朱学涛,朱立梅,等.血浆母系表达基因3和H19水平与妊娠期糖尿病胰岛素抵抗的关系[J].医学研究与战创伤救治(原医学研究生学报),2021,23(02):151-154.[doi:10.3969/j.issn.1672-271X.2021.02.009]
　SONG Xiao-dong,ZHU Xue-tao,ZHU Li-mei,et al.The relationship between plasma MEG3 and H19 levels and insulin resistance in gestational diabetes mellitus[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(02):151-154.[doi:10.3969/j.issn.1672-271X.2021.02.009]
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血浆母系表达基因3和H19水平与妊娠期糖尿病胰岛素抵抗的关系()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第23卷
期数:
2021年02期
页码:
151-154
栏目:
临床研究
出版日期:
2021-03-22

文章信息/Info

Title:
The relationship between plasma MEG3 and H19 levels and insulin resistance in gestational diabetes mellitus
作者:
宋晓东; 朱学涛; 朱立梅; 李伟
222002连云港,南京医科大学康达学院第一附属医院检验科(宋晓东、朱学涛、朱立梅、李伟)
Author(s):
SONG Xiao-dong;  ZHU Xue-tao;  ZHU Li-mei;  LI Wei
(Department of Clinical Laboratory, the First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang 222002,Jiangsu，China)
关键词:
母系表达基因3; H19; 妊娠期糖尿病; 胰岛素抵抗
Keywords:
maternally expressed gene 3;  H19;  gestational diabetes mellitus;  insulin resistance
分类号:
R714.2
DOI:
10.3969/j.issn.1672-271X.2021.02.009
文献标志码:
A
摘要:
目的探讨血浆母系表达基因3（MEG3）、H19水平与妊娠期糖尿病（GDM）胰岛素抵抗（IR）的关系。方法选取2016年1月至2019年1月间孕24~28周在南京医科大学康达学院第一附属医院行口服葡萄糖耐量试验（OGTT）并确诊为GDM的孕妇65例为GDM组，另外选取同期80例孕周为24~28周正常妊娠孕妇为对照组，检测2组空腹血糖（FPG）、糖化血红蛋白（HbA1c）、空腹胰岛素（FINS）、稳态模型胰岛素抵抗指数（HOMA-IR）、MEG3和H19水平并进行比较；采用Spearman分析GDM组血浆MEG3、H19水平与FPG、HbA1c、FINS、HOMA-IR的相关性；采用Logistic回归模型分析影响IR发生的因素。结果GDM组FPG、HbA1c、FINS、HOMA-IR均显著高于对照组（P<0.01）。GDM组血浆MEG3水平（0.62±0.11）显著低于对照组（1.03±0.25），H19水平（1.73±0.39）显著高于对照组（0.98±0.26），差异均有统计学意义（P<0.01）。Spearman相关分析结果显示，GDM组血浆MEG3水平与FPG、HbA1c、FINS、HOMA-IR均成负相关（P<0.01），血浆H19水平与FPG、HbA1c、FINS、HOMA-IR均呈正相关（P<0.01）。多因素Logistic回归分析结果显示，MEG3是IR发生的保护因素（P＜0.01），H19是危险因素（P＜0.01）。结论GDM患者血浆MEG3、H19水平与IR密切相关，临床监测MEG3、H19水平或可评估IR状况，以进行及时干预，改善母婴结局。
Abstract:
ObjectiveTo investigate the relationship between the levels of plasma maternal expression genes 3 (MEG3), H19 and insulin resistance (IR) in gestational diabetes mellitus (GDM).MethodsFrom January 2016 to January 2019, 65 pregnant women with GDM diagnosed by oral glucose tolerance test (OGTT) in our hospital from 24 to 28 weeks of gestation were selected as GDM group, in addition, 80 normal pregnant women with 24-28 weeks gestation were selected as the control group. The levels of fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c), fasting insulin (FINS), homeostasis model insulin resistance index (HOMA-IR), MEG3 and H19 were measured and compared between the two groups. Spearman was used to analyze the correlations between plasma MEG3, H19 and FPG, HbA1c, FINS, HOMA-IR. Logistic regression model was used to analyze the factors influencing the occurrence of IR.ResultsCompared with the control group, the FPG, HbA1c, FINS and HOMA-IR were higher in GDM group (P<0.01). The level of MEG3 in GDM group (0.62±0.11) was significantly lower than that in control group (1.03±0.25). The level of H19 in GDM group (1.73±0.39) was significantly higher than that in control group (0.98±0.26)(P<0.01). Spearman’s resultsshowed that the plasma MEG3 level was negatively correlated with FPG, HbA1c, FINS and HOMA-IR (P<0.01), while the plasma H19 level was positively correlated with FPG, HbA1c, FINS and HOMA-IR (P<0.01); Logistic regression analysis showed that MEG3 was the protective factor of IR (P<0.01), and H19 was the risk factor (P<0.01).ConclusionThe levels of MEG3 and H19 in plasma of GDM patients are closely associated with IR. Clinical monitoring of MEG3 and H19 levels may be able to evaluate IR status to quickly intervene and improve the outcome of mother and infant.

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更新日期/Last Update: 2021-03-22