|本期目录/Table of Contents|

[1]范佳杨,梁婷,刘康,等.糖酵解关键酶在宫颈癌Warburg效应中的作用研究进展[J].医学研究与战创伤救治(原医学研究生学报),2021,23(02):175-179.[doi:10.3969/j.issn.1672-271X.2021.02.014]
　FAN Jia-yang,LIANG Ting,LIU Kang,et al.Research progression of the infection of glycolytic enzymein the Warburg effect in cervical cancer[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(02):175-179.[doi:10.3969/j.issn.1672-271X.2021.02.014]
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糖酵解关键酶在宫颈癌Warburg效应中的作用研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第23卷
期数:
2021年02期
页码:
175-179
栏目:
综述
出版日期:
2021-03-22

文章信息/Info

Title:
Research progression of the infection of glycolytic enzymein the Warburg effect in cervical cancer
作者:
范佳杨; 梁婷; 刘康; 罗岳西
637000南充,川北医学院第二临床医学院(南充市中心医院)妇产科(范佳杨、梁婷、罗岳西);637000 南充,南充市中心医院组织工程与干细胞研究所(刘康)
Author(s):
FAN Jia-yang;  LIANG Ting ;  LIU Kang; LUO Yue-xi
(1.Department of Obstetrics and Gynecology, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College， Nanchong 637000,Sichuan,China; 2. Department of Tissue Engineering and Stem Cell Institute, Nanchong Central Hospital, Nanchong 637000,Sichuan,China)
关键词:
宫颈癌; Warburg效应; 糖酵解
Keywords:
cervical;  Warburg effect;  glycolysis
分类号:
R73
DOI:
10.3969/j.issn.1672-271X.2021.02.014
文献标志码:
A
摘要:
宫颈癌是女性最常见的恶性肿瘤之一，其发病率在全球范围内仅次于乳腺癌，死亡率位居全球第二。全世界每年约有50万名妇女被诊断出宫颈癌，有25万名妇女死于宫颈癌。Warburg效应存在于大部分肿瘤细胞中，是肿瘤细胞的代谢特征之一，又称为有氧糖酵解，是指在癌变时，无论是否缺氧，肿瘤细胞都更倾向于糖酵解的代谢途径，而非靠更有效的氧化磷酸化来产生能量。文章主要就醇化酶、磷酸甘油酸变位酶、己糖激酶、丙酮酸激酶、乳酸脱氢酶等在宫颈癌组织中表达异常，且在宫颈癌的发生发展过程中起重要作用的关键酶进行综述。
Abstract:
Cervical cancer is among the most common malignant tumors in women. Its incidence is second only to breast cancer in the world, and its mortality ranks second in the world.Around half a million women worldwide are diagnosed with cervical cancer each year and 250 000 women die from it.Warburg effect exists in most tumor cells and is part of the metabolic characteristics of tumor cells. Also known as aerobic glycolysis, it means that tumor cells prefer the metabolic pathway of glycolysis to generate energy by more effective oxidative phosphorylation regardless of hypoxia during cancerization.In this paper, Enolase, phosphoglycerate mutase (PGAM), Hexokinase (HK), pyruvate kinase (PK), lactate dehydrogenase (LDH) and other key enzymes that are abnormally expressed in cervical cancer tissues and play an important role in the occurrence and development of cervical cancer are reviewed.To explore biomarkers that can be used as diagnostic predictors of prognosis, or effective targets for gene therapy.

参考文献/References:

[1]Minion LE, Tewari Krishnansu S. Cervical cancer-State of the science: From angiogenesis blockade to checkpoint inhibition[J]. Gynecol Oncol, 2018, 148: 609-621.
[2]傅柳桃,王青元,卫兵,等.PGAM1通过激活Warburg效应调控宫颈癌细胞恶性生物学行为的机制研究[J].安徽医科大学学报,2018,53(9):1398-1402.
[3]Song Y, Luo Q, Long H,et al. Correction: Alpha-enolase as a potential cancer prognostic marker promotes cell growth, migration, and invasion in glioma[J].Mol Cancer, 2015, 13: 235.
[4]Tseng PL, Chen CW, Hu KH, et al. The decrease of glycolytic enzyme hexokinase 1 accelerates tumor malignancy via deregulating energy metabolism but sensitizes cancer cells to 2-deoxyglucose inhibition[J].Oncotarget, 2018, 9: 18949-18969.
[5]Lin YZ, Meng FQ, Lu ZY, et al. Knockdown of PKM2 suppresses tumor progression in human cervical cancer by modulating epithelial-mesenchymal transition via Wnt/β-catenin signaling[J].Cancer Manag Res, 2018, 10: 4191-4202.
[6]Warburg O. On the origin of cancer cells. Science [J]. Science, 1956,123(3 191):309-314.
[7]Li L, Liang YC, Kang L, et al. Transcriptional Regulation of the Warburg Effect in Cancer by SIX1[J].Cancer Cell, 2018, 33: 368-385.e7.
[8]Akins NS, Nielson TC, Le HV. Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer[J].Curr Top Med Chem, 2018, 18: 494-504.
[9]Zheng YF, Liu PX, Wang N, et al. Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway[J].Oxid Med Cell Longev, 2019, 2019: 8781690.
[10]Altenberg B, Greulich KO. Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes [J]. Genomics, 2004,84(6):1014-1020.
[11]Capello M, Ferri-Borgogno S, Riganti C, et al. Targeting the Warburg effect in cancer cells through ENO1 knockdown rescues oxidative phosphorylation and induces growth arrest[J].Oncotarget, 2016, 7: 5598-5612.
[12]Yu L, Shi JD, Cheng S, et al. Estrogen promotes prostate cancer cell migration via paracrine release of ENO1 from stromal cells[J].Mol Endocrinol, 2012, 26: 1521-1530.
[13]Siu MKY, Jiang YX, Wang JJ, et al. Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades[J].Cancers (Basel), 2019, 11: undefined.
[14]Zhou JY, Zhang SZ, Chen ZM, et al. CircRNA-ENO1 promoted glycolysis and tumor progression in lung adenocarcinoma through upregulating its host gene ENO1[J].Cell Death Dis, 2019, 10: 885.
[15]Wang L,Yin H, Bi RR, et al. ENO1-targeted superparamagnetic iron oxide nanoparticles for detecting pancreatic cancer by magnetic resonance imaging[J].J Cell Mol Med, 2020, 24: 5751-5757.
[16]Bretones G, Delgado MD, Leon J. Myc and cell cycle control [J]Bio Chim Biophys Acta,2015,1849:506-516.
[17]Hsu KW, Hsieh RH, Wu CW, et al. MBP-1 suppresses growth and metastasis of gastric cancer cells through COX-2 [J]. Molecular Cell Biology, 2009, 20(24):5127-5137.
[18]蔡鑫,梁婷,罗岳西. α-烯醇化酶在肿瘤发生发展中的作用机制研究进展［J］. 东南国防医药，2021,23（1）:50-53.
[19]Ji H, Wang JF, Guo JR, et al. Progress in the biological function of alpha-enolase[J].Anim Nutr, 2016, 2: 12-17.
[20]张栋栋，刘会玲，范维，等.慢病毒介导的α-烯醇化酶基因沉默对宫颈癌细胞化疗药物敏感性的影响[J].世界科技研究与发展，2014, 4 (36) :398-401.
[21]Liu SE，Hu JC，Zhang H，et al．Conformation and dynamics of the C-terminal region in human phosphoglycerate mutase 1[J]．Acta Pharmacol Sin，2017，38(12)：1673-82．
[22]Mathupala SP, Ko YH, Pedersen PL. Hexokinase II: cancer’s double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria[J]. Oncogene, 2006, 25: 4777-4786.
[23]Sullivan MA,Forbes JM. Glucose and glycogen in the diabetic kidney: Heroes or villains?[J] EBio Medicine, 2019, 47: 590-597.
[24]Caillot M, Bourgeais J, Dakik H, et al. Cyclin D1 targets hexokinase 2 to control aerobic glycolysis in myeloma cells[J].Oncogenesis, 2020, 9: 68.
[25]Weh E, Lutrzykowska Z, Smith A, et al. Hexokinase 2 is dispensable for photoreceptor development but is required for survival during aging and outer retinal stress[J]. Cell Death Dis, 2020, 11: 422.
[26]Zeng Q, Chen J, Li Y, et al. LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism[J]. Oncogene, 2017, 36: 1245-1255.
[27]Li WC, Huang CH, Hsieh YT, et al. Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis[J]. Front Oncol, 2020, 10: 176.
[28]Kudryavtseva AV, Fedorova MS, Zhavoronkov A, et al. Effect of lentivirus-mediated shRNA inactivation of HK1, HK2, and HK3 genes in colorectal cancer and melanoma cells[J]. BMC Genet, 2016, 17: 156.
[29]Xu SL, Catapang A,Doh HM, et al. Hexokinase 2 is targetable for HK1 negative, HK2 positive tumors from a wide variety of tissues of origin[J]. J Nucl Med, 2018, undefined.
[30]Abu-Hamad S, Zaid H, Israelson A, et al. Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding[J]. J Biol Chem, 2008, 283: 13482-13490.
[31]Galluzzi L,Kepp O,Tajeddine N, et al. Disruption of the hexokinase-VDAC complex for tumor therapy[J]. Oncogene, 2008, 27: 4633-4635.
[32]Sun L, Shukair S, Naik TJ, et al. Glucose phosphorylation and mitochondrial binding are required for the protective effects of hexokinases I and II[J]. Mol Cell Biol, 2008, 28: 1007-1017.
[33]Feng J, Li JJ,Wu LW, et al. Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma[J]. J Exp Clin Cancer Res, 2020, 39: 126.
[34]Pan YH, Wang W, HS, et al. Beta-elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation[J]. J Cell Mol Med, 2019, 23: 6846-6858.
[35]Lee KM, Giltnane JM, Balko JM, et al. MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation[J]. Cell Metab, 2017, 26: 633-647.e7.
[36]Liu X, Zhou YY, Peng JM, et al. Silencing c-Myc Enhances the Antitumor Activity of Bufalin by Suppressing the HIF-1α/SDF-1/CXCR4 Pathway in Pancreatic Cancer Cells[J]. Front Pharmacol, 2020, 11: 495.
[37]Urbańska K, Orzechowski A. Unappreciated Role of LDHA and LDHB to Control Apoptosis and Autophagy in Tumor Cells[J]. Int J Mol Sci, 2019, 20: undefined.
[38]蒋晓月,江瑛. 乳酸脱氢酶和Warburg效应的研究进展[J].生物科学进展, 2017,48(5):352-356.
[39]Serganova I, Cohen IJ, Vemuri K, et al. LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response[J]. PLoS One, 2018, 13: e0203965．
[40]Manerba M, Di IL, Govoni M, et al. The activation of lactate dehydrogenase induced by mTOR drives neoplastic change in breast epithelial cells[J].PLoS One, 2018, 13: e0202588．
[41]Brown NJ，Higham SE，Pemnovic B，et al．Lactate dehydrogenase·B is silenced by pmmoter methylation in a high fkquency of human breast cancers[J].PLoS 0ne，2013，8：e57697-e57697．

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备注/Memo

备注/Memo:
基金项目： 四川省教育厅项目（１６ＺＡ０２３９）；南充市校科技战略合作项目（１８ＳＸＨＺ０３６１）
更新日期/Last Update: 2021-03-22