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[1]杜雨欣,张利东.氯胺酮抗创伤后应激障碍作用的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2021,23(03):293-297.[doi:10.3969/j.issn.1672-271X.2021.03.015]
　DU Yu-xin,ZHANG Li-dong.Research progress in the role of ketamine in post-traumatic stress disorder[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(03):293-297.[doi:10.3969/j.issn.1672-271X.2021.03.015]
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氯胺酮抗创伤后应激障碍作用的研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第23卷
期数:
2021年03期
页码:
293-297
栏目:
综述
出版日期:
2021-06-20

文章信息/Info

Title:
Research progress in the role of ketamine in post-traumatic stress disorder
作者:
杜雨欣; 张利东
作者单位：210002南京，南方医科大学南京临床医学院（东部战区总医院）麻醉科(杜雨欣、张利东)
Author(s):
DU Yu-xin ; ZHANG Li-dong
(Department of Anesthesiology, Jinling Hospital, Nanjing School Clinical Medicine, Southern Medical University/General Hospital of Eastern Theater Command, PLA, Nanjing 210002,Jiangsu,China)
关键词:
氯胺酮; 创伤后应激障碍; 临床应用; 分子机制
Keywords:
ketamine; post-traumatic stress disorder; clinical application; molecular mechanisms
分类号:
R971.2
DOI:
10.3969/j.issn.1672-271X.2021.03.015
文献标志码:
A
摘要:
创伤后应激障碍的治疗是目前临床工作面临的的重点和难点。现用于治疗创伤后应激障碍的药物较少且疗效有限。近年来发现氯胺酮具有快速、高效的抗抑郁作用，越来越多的学者开始研究其治疗创伤后应激障碍的作用。文章回顾了国内外关于氯胺酮在创伤后应激障碍中的相关研究，重点就氯胺酮在治疗创伤后应激障碍中临床应用，可能的分子机制及其可行性及安全性的研究进展进行综述。
Abstract:
The treatment of post-traumatic stress disorder (PTSD) is a priority and difficulty in clinical work at present. There are few medications with demonstrated efficacy for the treatment of PTSD. Several clinical trials have reported the rapid and efficient antidepressant properties of ketamine, and it is increasingly studied for the treatment of PTSD. This paper reviewed researches for ketamine in the treatment of PTSD. This review focused on the clinical application, potential mechanisms and safety of administration ketamine for PTSD.

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备注/Memo

备注/Memo:
基金项目：军委后勤保障部卫生局军事医学创新工程专项基金（20WQ025）
更新日期/Last Update: 2021-06-17