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[1]胡丽花,赵嫦娥,宋成文.增敏化疗对宫颈癌同步放疗患者生存质量和免疫功能的影响研究[J].医学研究与战创伤救治(原医学研究生学报),2021,23(6):588-591.[doi:10.3969/j.issn.1672-271X.2021.06.006]
　HU Li-hua,ZHAO Chang-e,SONG Cheng-wen.Study on the effect of sensitization chemotherapy on the quality of life and immune function of patients with cervical cancer receiving concurrent radiotherapy[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(6):588-591.[doi:10.3969/j.issn.1672-271X.2021.06.006]
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增敏化疗对宫颈癌同步放疗患者生存质量和免疫功能的影响研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第23卷
期数:
2021年6期
页码:
588-591
栏目:
临床研究
出版日期:
2021-12-15

文章信息/Info

Title:
Study on the effect of sensitization chemotherapy on the quality of life and immune function of patients with cervical cancer receiving concurrent radiotherapy
作者:
胡丽花; 赵嫦娥; 宋成文
作者单位：430070武汉，中部战区总医院妇产科（胡丽花、赵嫦娥、宋成文）
Author(s):
HU Li-hua;  ZHAO Chang-e;  SONG Cheng-wen
(Department of Obstetrics and Gynecology, General Hospital of the Central War Zone，PLA, Wuhan 430070,Hubei, China)
关键词:
宫颈癌; 增敏化疗; 顺铂; 免疫功能; 生存质量; 不良反应
Keywords:
cervical cancer;  sensitized chemotherapy;  cisplatin;  immune function;  quality of life;  adverse reactions
分类号:
R737.33
DOI:
10.3969/j.issn.1672-271X.2021.06.006
文献标志码:
A
摘要:
目的探讨增敏化疗对宫颈癌同步放疗患者生存质量、免疫功能的影响，为患者诊疗提供依据。方法选取2017年11月-2019年7月期间中部战区总医院收治的宫颈癌患者120例，根治治疗方案不同将患者分联合组（n=65）和对照组（n=55）。对照组采用强调放疗，联合组在此基础上联合顺铂同步增敏。比较治疗后效果，记录2组治疗前、治疗后T淋巴细胞、血清CA125、白细胞介素-6（IL-6）、干扰素-y（IFN-y）、生活质量（QOL）评分、卡氏体力（KPS）评分变化，统计不良反应发生情况。结果联合组总有效率高于对照组（90.77% vs 76.36%），差异有统计学意义（P<0.05）。2组患者治疗后的T淋巴细胞比较，差异有统计学意义（P<0.05）；2组患者治疗后的血清CA125、IL-6表达水平均降低，且联合组[（36.18±3.78）IU/mL、（37.16±3.27）pg/mL]低于对照组[（45.12±4.13）IU/mL、（43.62±3.51）pg/mL]，而IFN-y表达水平升高，且联合组[（20.16±2.10）pg/mL]高于对照组[（15.12±1.98）pg/mL]，差异有统计学意义（P<0.05）。2组治疗后患者的QOL评分、KPS评分均升高，且联合组[（56.79±4.16）分、（81.13±4.10分）]高于对照组[（43.28±3.60）分、（76.98±3.58分）]，差异有统计学意义（P<0.05）。2组不良反应比较差异无统计学意义（P>0.05）。结论顺铂辅助用于宫颈癌化疗的增敏效果明显，有效提高患者的T细胞免疫功能，调节血清CA125、IL-6、IFN-y水平，改善患者生存质量，并未增加不良反应，值得临床推广使用。
Abstract:
ObjectiveTo explore the effect of sensitization chemotherapy on the quality of life and immune function of patients with cervical cancer undergoing concurrent radiotherapy, so as to provide the basis for diagnosis and treatment.MethodsFrom November 2017 to July 2019, 120 patients with cervical cancer were selected. The patients were divided into observation group (n=65) and control group (n=55).The control group used in IMRT, and the observation group was combined with cisplatin for simultaneous sensitization. The changes of T-lymphocyte, serum CA125, IL-6, IFN-y, QOL and KPS were recorded before and after treatment.ResultsCompared with the total effective rate of the observation group and the control group (90.77% vs 76.36%), the difference was significant (P<0.05). After treatment, the comparison of T lymphocytes between the two groups was significant (P<0.05); After treatment, the expression levels of serum CA125 and IL-6 of the two groups of patients decreased, and the observation group [(36.18±3.78)IU/mL, (37.16±3.27)pg/mL] was lower than the control group [(45.12±4.13)IU/mL, (43.62±3.51)pg/mL], and the expression level of IFN-y increased, and the observation group [(20.16±2.10)pg/mL] was higher than the control group [(15.12± 1.98)pg/mL], the difference was significant (P<0.05). After treatment, the QOL scores and KPS scores of the two groups increased, and the observation group [(56.79±4.16) points, (81.13±4.10) points] were higher than the control group [(43.28±3.60) points, (76.98±3.58) points], the difference was significant (P<0.05). There was not any difference in adverse reactions between the two groups (P>0.05).ConclusionCisplatin-assisted chemotherapy for cervical cancer has obvious sensitization effect, effectively improves T-cell immune function of patients, regulates serum CA125, IL-6, IFN-y levels, improves patients’ quality of life, reduces adverse reactions, and is worthy of clinical promotion.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2021-12-15