|本期目录/Table of Contents|

[1]陈美惠,贾佳,曹燕丽,等.抑郁症患者性激素异常及治疗的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2021,23(6):633-636.[doi:10.3969/j.issn.1672-271X.2021.06.016]
　CHEN Mei-hui,JIA Jia,CAO Yan-li,et al.Development on hormone abnormalities and treatment in patients with major depression[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(6):633-636.[doi:10.3969/j.issn.1672-271X.2021.06.016]
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抑郁症患者性激素异常及治疗的研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第23卷
期数:
2021年6期
页码:
633-636
栏目:
综述
出版日期:
2021-12-15

文章信息/Info

Title:
Development on hormone abnormalities and treatment in patients with major depression
作者:
陈美惠; 贾佳; 曹燕丽;  龚光明
作者单位：210002南京，东部战区总医院(原南京军区南京总医院)药剂科（陈美惠、贾佳、曹燕丽），医学工程科 （龚光明）
Author(s):
CHEN Mei-hui;  JIA Jia;  CAO Yan-li ;  GONG Guang-ming
（1.Department of Pharmacy, 2. Department of Medical Engineering,General Hospital of Eastern Theater Command，PLA,Nanjing 210002, Jiangsu，China）
关键词:
抑郁症; 性激素; 异常; 临床; 治疗
Keywords:
depression;  hormone;  abnormality;  clinical;  therapy
分类号:
R458.7
DOI:
10.3969/j.issn.1672-271X.2021.06.016
文献标志码:
A
摘要:
卵巢激素的波动与抑郁风险增加有关。用于预防怀孕或使月经周期正常的口服避孕药，有可能改变情绪，但 仅用孕激素减轻抑郁症状相关的证据不足。卵巢激素对情绪的作用，受多重因素的影响。研究表明，通过口服避孕 药抑制排卵和GnRH激动剂的联用对经前期综合征有一定效果。另外，更年期的早期实施雌激素替代疗法(ERT)或激素 替代疗法(HRT)是最有效的进行抑郁干预的方法。患抑郁症的中、老年男性总睾酮和游离睾酮水平均低于正常男性， 睾酮可能是治疗轻度抑郁症的有效方法，脱氢表雄酮对HIV阳性患者的轻度抑郁有疗效。文章就抑郁症患者激素治疗 最新进展进行综述。
Abstract:
Fluctuations in ovarian hormones are associated with an increased risk of depressive states. Oral contraceptives, used to prevent pregnancy or normalize the menstrual cycle, have been thought to potentially alter mood. However, there has been scant evidence linking progesterone-only contraceptives to depressive symptoms. Estrogen replacement therapy (ERT) or hormone replacement therapy (HRT) is the most effective way to intervene with depression in the early stages of menopausal transition. Iterogesterone has significant anti-anxiety and antidepressant properties, as well as the ability to inhibit HPA axis activity. In middle and later life, both total and free testosterone levels were lower in men with major depressive disorder than in men without depression. Testosterone may be an effective treatment for depressive symptoms in NMDD, and DHEA has been shown to be effective in NMDD in HIV-positive patients.

参考文献/References:

[1]Du H, Wang K, Su L, et al. Metabonomic identification of the effects of the Zhimu-Baihe saponins on a chronic unpredictable mild stress-induced rat model of depression[J]. J Pharm Biomed Anal, 2016, 128(5): 469-479.
[2]Lepine JP, Briley M. The increasing burden of depression[J]. Neuropsychiatr Dis Treat, 2011,7 (Suppl 1): 3-7.
[3]Altemus M, Sarvaiya N, Neill Epperson C. Sex differences in anxiety and depression clinical perspectives[J]. Front Neuroendocrinol, 2014, 35(3): 320-330.
[4]Rachman IM, Unnerstall JR, Pfaff DW, et al. Estrogen alters behavior and forebrain c-fos expression in ovariectomized rats subjected to the forced swim test[J]. Proc Natl Acad Sci U S A, 1998, 95(23): 13941-13946.
[5]Rubinow DR, Johnson SL, Schmidt PJ, et al. Efficacy of Estradiol in Perimenopausal Depression: So Much Promise and So Few Answers[J]. Depress Anxiety, 2015, 32(8): 539-549.
[6]Skovlund CW, Morch LS, Kessing LV, et al. Association of Hormonal Contraception With Depression [J]. JAMA Psychiatry, 2016, 73(11): 1154-1162.
[7]Svendal G, Berk M, Pasco JA, et al. The use of hormonal contraceptive agents and mood disorders in women[J]. J Affect Disord, 2012, 140(1): 92-96.
[8]Worly BL, Gur TL, Schaffir J. The relationship between progestin hormonal contraception and depression: a systematic review[J]. Contraception, 2018, 97(6): 478-489.
[9]Dokras A, Sarwer DB, Allison KC, et al. Weight Loss and Lowering Androgens Predict Improvements in Health-Related Quality of Life in Women With PCOS[J]. J Clin Endocrinol Metab, 2016, 101(8): 2966- 2974.
[10]Yonkers KA, Brown C, Pearlstein TB, et al. Efficacy of a new low-dose oral contraceptive with drospirenone in premenstrual dysphoric disorder[J]. Obstet Gynecol, 2005, 106(3): 492-501.
[11]Schmidt PJ, Nieman LK, Danaceau MA, et al. Differential behavioral effects of gonadal steroids in women with and in those without premenstrual syndrome[J]. N Engl J Med, 1998, 338(4): 209-216.
[12]Mocellin S, Goodwin A, Pasquali S. Risk-reducing medications for primary breast cancer: a network meta-analysis[J]. Cochrane Database Syst Rev, 2019, 4: CD012191.
[13]Dias RS, Kerr-Correa F, Moreno RA, et al. Efficacy of hormone therapy with and without methyltestosterone augmentation of venlafaxine in the treatment of postmenopausal depression: a double-blind controlled pilot study[J]. Menopause, 2006, 13(2): 202-211.
[14]Rasgon NL, Dunkin J, Fairbanks L, et al. Estrogen and response to sertraline in postmenopausal women with major depressive disorder: a pilot study[J]. J Psychiatr Res, 2007, 41(3-4): 338-343.
[15]Gordon JL, Rubinow DR, Eisenlohr-Moul TA, et al. Efficacy of Transdermal Estradiol and Micronized Progesterone in the Prevention of Depressive Symptoms in the Menopause Transition: A Randomized Clinical Trial[J]. JAMA Psychiatry, 2018, 75(2): 149-157.
[16]Smith JB, Rosen J, Colbert A. Low Serum Testosterone in Outpatient Psychiatry Clinics: Addressing Challenges to the Screening and Treatment of Hypogonadism[J]. Sex Med Rev, 2018, 6(1): 69-76.
[17]McIntyre RS, Mancini D, Eisfeld BS, et al. Calculated bioavailable testosterone levels and depression in middle-aged men[J]. Psychoneuroendocrinology, 2006, 31(9): 1029-1035.
[18]Giltay EJ, van der Mast RC, Lauwen E, et al. Plasma Testosterone and the Course of Major Depressive Disorder in Older Men and Women[J]. Am J Geriatr Psychiatry, 2017, 25(4): 425-437.
[19]Westley CJ, Amdur RL, Irwig MS. High Rates of Depression and Depressive Symptoms among Men Referred for Borderline Testosterone Levels[J]. J Sex Med, 2015, 12(8): 1753-1760.
[20]Shores MM, Sloan KL, Matsumoto AM, et al. Increased incidence of diagnosed depressive illness in hypogonadal older men[J]. Arch Gen Psychiatry, 2004, 61(2): 162-167.
[21]Jung HJ, Shin HS. Effect of Testosterone Replacement Therapy on Cognitive Performance and Depression in Men with Testosterone Deficiency Syndrome[J]. World J Mens Health, 2016, 34(3): 194- 199.
[22]Seidman SN, Orr G, Raviv G, et al. Effects of testosterone replacement in middle-aged men with dysthymia: a randomized, placebo-controlled clinical trial[J]. J Clin Psychopharmacol, 2009, 29(3): 216-221.
[23]Shores MM, Kivlahan DR, Sadak TI, et al. A randomized, double-blind, placebo-controlled study of testosterone treatment in hypogonadal older men with subthreshold depression (dysthymia or minor depression) [J]. J Clin Psychiatry, 2009, 70(7): 1009-1016.
[24]Grinspoon S, Corcoran C, Stanley T, et al. Effects of hypogonadism and testosterone administration on depression indices in HIV-infected men[J]. J Clin Endocrinol Metab, 2000, 85(1): 60-65.
[25]Rabkin JG, Wagner GJ, Rabkin RA. double-blind, placebo-controlled trial of testosterone therapy for HIV-positive men with hypogonadal symptoms[J]. Arch Gen Psychiatry, 2000, 57(2): 141-714.
[26]Rabkin JG, Wagner GJ, McElhiney MC, et al. Testosterone versus fluoxetine for depression and fatigue in HIV/AIDS: a placebo-controlled trial[J]. J Clin Psychopharmacol, 2004, 24(4): 379-385.
[27]Petering RC,Brooks NA. Testosterone Therapy: Review of Clinical Applications[J]. Am Fam Physician, 2017, 96(7): 441-449.
[28]Rabkin JG, McElhiney MC, Rabkin R, et al. Placebo-controlled trial of dehydroepiandrosterone (DHEA) for treatment of nonmajor depression in patients with HIV/AIDS[J]. Am J Psychiatry, 2006, 163 (1): 59-66.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金(31671026)
更新日期/Last Update: 2021-12-15