|本期目录/Table of Contents|

[1]徐畅,张利东.犬尿氨酸代谢通路在抑郁症中的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2022,24(1):69-72.[doi:10.3969/j.issn.1672-271X.2022.01.015]
　XU Chang,ZHANG Li-dong.Research advances of kynurenine pathway in depressive disorder[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2022,24(1):69-72.[doi:10.3969/j.issn.1672-271X.2022.01.015]
点击复制

犬尿氨酸代谢通路在抑郁症中的研究进展()
分享到62.8K

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第24卷
期数:
2022年1期
页码:
69-72
栏目:
综述
出版日期:
2022-02-20

文章信息/Info

Title:
Research advances of kynurenine pathway in depressive disorder
作者:
徐畅; 张利东
作者单位：210002南京，南京大学医学院附属金陵医院（东部战区总医院）麻醉科（徐畅、张利东）
Author(s):
XU Chang ;  ZHANG Li-dong
(Department of Anesthesiology, Jinling Hospital, Medical School of Nanjing University/General Hospital of Eastern Theater Command，PLA，Nanjing 210002，Jiangsu，China)
关键词:
犬尿氨酸; 犬尿氨酸代谢通路; 抑郁症; 喹啉酸; 犬尿烯酸
Keywords:
kynurenine;  kynurenine pathway;  depression;  quinolinic acid; kynurenine acid
分类号:
R749
DOI:
10.3969/j.issn.1672-271X.2022.01.015
文献标志码:
A
摘要:
犬尿氨酸代谢通路（KP）是色氨酸代谢的主要途径。越来越多的研究表明，色氨酸经KP代谢产生的一系列活性物质与抑郁症的发生、发展密切相关。有研究表示，抑郁症患者炎症因子水平的升高与KP代谢密切相关，如导致神经毒性产物QUIN增高、保护产物KYNA降低。文章主要对KP、代谢产物及其参与抑郁症的发病与治疗等相关问题进行综述。
Abstract:
The kynurenine pathway is a major route of tryptophan metabolism. Emerging evidence suggests that a series of kynurenine metabolites are involved in the occurrence and development of depression. Studies have shown that increased levels of inflammatory factors in patients with depression are closely related to kynurenine metabolites, such as increased levels of neurotoxic product quinolinic acid and decreased levels of neuroprotective product kynurenine acid. This review focuses onthe metabolic pathway, metabolites and relevant issues in the pathogenesis and treatment of depression, aiming to provide new targets and predictive methods for the treatment of depression.

参考文献/References:

[1]胡海岚.情感与社会行为的神经机制研究进展[J].中国科学:生命科学,2021,51(2):105-115.
[2]Quintana DS, Steen NE, Andreassen OA. The Promise of Intranasal Esketamine as a Novel and Effective Antidepressant[J]. JAMA Psychiatry, 2018, 75(2):123-124.
[3]Tao X, Yan M, Wang L, et al. Homeostasis Imbalance of Microglia and Astrocytes Leads to Alteration in the Metabolites of the Kynurenine Pathway in LPS-Induced Depressive-LikeMice[J]. Int J Mol Sci, 2020, 21(4):1460.
[4]Kennedy PJ, Cryan JF, Dinan TG, et al. Kynurenine pathway metabolism and the microbiota-gut-brain axis[J]. Neuropharmacology, 2017, 112(Pt B):399-412.
[5]王丽莎,刘新民,冯利,等.犬尿氨酸通路在神经退行性疾病中的研究进展[J].中国比较医学杂志,2015,25(11):69-75.
[6]Muneer A. Kynurenine Pathway of Tryptophan Metabolism in Neuropsychiatric Disorders: Pathophysiologic and TherapeuticConsiderations[J]. Clin Psychopharmacol Neurosci, 2020, 18(4):507-526.
[7]ztürk M, Yaln Sapmaz �瘙 塁 , Kandemir H, et al. The role of the kynurenine pathway and quinolinic acid in adolescent major depressive disorder[J]. Int J Clin Pract, 2021,75(4):e13739.
[8]Heisler JM, O’Connor JC. Indoleamine 2,3-dioxygenase-dependent neurotoxic kynurenine metabolism mediates inflammation-induced deficit in recognition memory[J]. Brain Behav Immun, 2015, 50:115-124.
[9]Ogyu K, Kubo K, Noda Y, et al. Kynurenine pathway in depression: A systematic review and meta-analysis[J]. Neurosci Biobehav Rev, 2018, 90:16-25.
[10]Kim YK, Jeon SW. Neuroinflammation and the Immune-Kynurenine Pathway in AnxietyDisorders[J]. Curr Neuropharmacol, 2018, 16(5):574-582.
[11]O’Farrell K, Fagan E, Connor TJ, et al. Inhibition of the kynurenine pathway protects against reactive microglial-associated reductions in the complexity of primary corticalneurons[J]. Eur J Pharmacol, 2017, 810:163-173.
[12]da Silveira TL, Zamberlan DC, Arantes LP, et al. Quinolinic acid and glutamatergic neurodegeneration in Caenorhabditis elegans[J]. Neurotoxicology, 2018, 67:94-101.
[13]Baranyi A, Meinitzer A, Breitenecker RJ, et al. Quinolinic Acid Responses during Interferon-alpha-Induced Depressive Symptomatology in Patients with Chronic Hepatitis C Infection - A Novel Aspect for Depression and Inflammatory Hypothesis[J]. PLoS One, 2015, 10(9):e0137022.
[14]Erhardt S, Lim CK, Linderholm KR, et al. Connecting inflammation with glutamate agonism insuicidality[J]. Neuropsychopharmacology, 2013, 38(5):743-752.
[15]Bartoli F, Misiak B, Callovini T, et al. The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and relatedmetabolites[J]. Mol Psychiatry, 26,7 (2021): 3419-3429.
[16]Wiedlocha M, Marcinowicz P, Krupa R, et al. Effect of antidepressant treatment on peripheral inflammation markers - A meta-analysis[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2018, 80(Pt C):217-226.
[17]Savitz J, Drevets WC, Wurfel BE, et al. Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressivedisorder[J]. Brain Behav Immun, 2015, 46:55-59.
[18]Bay-Richter C, Linderholm KR, Lim CK, et al. A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality[J]. Brain Behav Immun, 2015, 43:110-117.
[19]Birner A, Platzer M, Bengesser SA, et al. Increased breakdown of kynurenine towards its neurotoxic branch in bipolardisorder[J]. PLoS One, 2017, 12(2):e0172699.
[20]Brundin L, Sellgren CM, Lim CK, et al. An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity andneuroinflammation[J]. Transl Psychiatry, 2016, 6(8):e865.
[21]Liu X-C, Erhardt S, Goiny M, et al. Decreased levels of kynurenic acid in prefrontal cortex in a genetic animal model ofdepression[J]. Acta Neuropsychiatr, 2017, 29(1):54-58.
[22]Laumet G, Zhou W, Dantzer R, et al. Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathicpain[J]. Brain Behav Immun, 2017, 66:94-102.
[23]Zhang K, Liu R, Gao Y, et al. Electroacupuncture Relieves LPS-Induced Depression-Like Behaviour in Rats Through IDO-Mediated Tryptophan-DegradingPathway[J]. Neuropsychiatr Dis Treat, 2020, 16:2257-2266.
[24]Fischer CW, Eskelund A, Budac DP, et al. Interferon-alpha treatment induces depression-like behaviour accompanied by elevated hippocampal quinolinic acid levels in rats[J]. Behav Brain Res, 2015, 293:166-172.
[25]Souza LC, Jesse CR, de Gomes MG, et al. Activation of Brain Indoleamine-2,3-dioxygenase Contributes to Depressive-Like Behavior Induced by an Intracerebroventricular Injection of Streptozotocin in Mice[J]. Neurochem Res, 2017, 42(10):2982-2995.
[26]Fertan E, Stover KRJ, Brant MG, et al. Effects of the Novel IDO Inhibitor DWG-1036 on the Behavior of Male and Female 3xTg-ADMice[J]. Front Pharmacol, 2019, 10:1044.
[27]Bano S, Gitay M, Ara I, et al. Acute effects of serotonergic antidepressants on tryptophan metabolism and corticosterone levels inrats[J]. Pak J Pharm Sci, 2010, 23(3):266-272.
[28]Zhou Y, Zheng W, Liu W, et al. Antidepressant effect of repeated ketamine administration on kynurenine pathway metabolites in patients with unipolar and bipolar depression[J]. Brain Behav Immun, 2018, 74:205-212.

相似文献/References:

备注/Memo

备注/Memo:
-
更新日期/Last Update: 2022-02-21