|本期目录/Table of Contents|

[1]何烜亚,陈兆耀,张琳,等.颈动脉斑块超声血管造影分级与病理微血管密度的相关性[J].医学研究与战创伤救治(原医学研究生学报),2022,24(2):118-122.[doi:10.3969/j.issn.1672-271X.2022.02.002]
　HE Xuan-ya,CHEN Zhao-yao,ZHANG Lin,et al.Correlation between contrast-enhanced ultrasound grading of carotid atherosclerotic plaque and microvessel density densityon pathology[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2022,24(2):118-122.[doi:10.3969/j.issn.1672-271X.2022.02.002]
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颈动脉斑块超声血管造影分级与病理微血管密度的相关性()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第24卷
期数:
2022年2期
页码:
118-122
栏目:
临床研究
出版日期:
2022-03-20

文章信息/Info

Title:
Correlation between contrast-enhanced ultrasound grading of carotid atherosclerotic plaque and microvessel density densityon pathology
作者:
何烜亚; 陈兆耀; 张琳; 刘牛; 李辉
作者单位：210021南京，南京中医药大学附属医院神经内科（何烜亚、陈兆耀、张琳、李辉），超声医学科（刘牛）
Author(s):
HE Xuan-ya;  CHEN Zhao-yao;  ZHANG Lin;  LIU Niu;  LI Hui
(Department of Neurology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210021, Jiangsu, China)
关键词:
颈动脉粥样硬化; 斑块内新血管形成; 超声血管造影; 病理
Keywords:
carotid atherosclerosis;  intraplaque neovascularization;  contrast-enhanced ultrasound;  pathology
分类号:
R543.5
DOI:
10.3969/j.issn.1672-271X.2022.02.002
文献标志码:
A
摘要:
目的探索超声血管造影(CEUS)检测到的颈动脉粥样硬化斑块内新生血管是否与斑块病理检测的微血管存在相关性。方法前瞻性入组行颈动脉内膜剥脱术（CEA）的20例患者，所有患者术前行CEUS 检查，并按照检测到的斑块内增强情况分为0~3级，术后对患者斑块标本行常规HE染色及CD31单克隆抗体标记的免疫组化染色，并根据CD31标记的斑块内微血管计算微血管密度（MVD），通过相关性分析检验CEUS分级与MVD的相关性。结果20例患者的平均年龄为（64.9±7.1）岁，其中高血压病史13例(85%)，糖尿病病史5例(25%)，脑梗死病史17例(85%)，冠心病病史3例(15%)，外周血管病病史8例(40%)，吸烟病史5例(25%)，长期饮酒史2例(10%)。CEUS成像检测了20个目标斑块，按照0~3级的分级标准，其中1级2个（10%），2级7个（35%），3级11个（55%）。CD31免疫组化染色200倍高倍镜下MVD为（9.37±3.56）条/mm2。Spearman相关性分析显示CEUS新生血管分级与MVD呈正相关相关（r=0.662，P=0.001）。结论颈动脉粥样硬化斑块CEUS 的增强分级与斑块内新生血管密度密切相关。
Abstract:
ObjectiveExploring whether neovascularisation within carotid atherosclerotic plaques detected by ultrasound angiography (CEUS) correlates with microvessels detected by plaque pathology.MethodsFor the enrolled patients undergoing CEA surgery, all patients underwent CEUS examination before surgery, and were classified into 0-3 grades according to the detected intraplaque enhancement. After surgery, routine HE staining was performed on the plaque samples of patients, and CD31 markers were used to show intraplaque microvessels, and MVD was calculated. The correlation between CEUS grade and MVD was established by correlation analysis.ResultsWe enrolled 20 patients with an average age of (64.9±7.1) years, including 13 patients (85%) with hypertension, 5 patients (25%) with diabetes, 8 patients (40%) with cerebral infarction, 3 patients (15%) with coronary heart disease, 8 patients (40%) with peripheral vascular disease, 5 patients (25%) with smoking, and 2 patients (10%) with long-term drinking history. CEUS imaging detected 20 target plaques on a scale of 0-3, including 2 in grade 1 (10%), 7 in grade 2 (35%), and 11 in grade 3 (55%). The MVD value of CD31 immunohistochemical staining was (9.37±3.56) /mm2 at 200 times high magnification. Spearman correlation analysis showed that CEUS neovascularization grade was positively correlated with MVD (r=0.662, P=0.001).ConclusionCEUS enhancement grade is closely related to intraplaque microvessel density.

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备注/Memo

备注/Memo:
基金项目：江苏省自然科学基金（BK20201095）
更新日期/Last Update: 2022-04-18