|本期目录/Table of Contents|

[1]钟善传,王丽,周斌,等.冻干血浆在平战时的应用与研究进展[J].医学研究与战创伤救治(原医学研究生学报),2022,24(3):310-314.[doi:10.3969/j.issn.1672-271X.2022.03.019]
　ZHONG Shan-chuan,WANG Li,ZHOU Bin,et al.Application and research progress of freeze dried plasma in peacetime and wartime[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2022,24(3):310-314.[doi:10.3969/j.issn.1672-271X.2022.03.019]
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冻干血浆在平战时的应用与研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第24卷
期数:
2022年3期
页码:
310-314
栏目:
综述
出版日期:
2022-06-30

文章信息/Info

Title:
Application and research progress of freeze dried plasma in peacetime and wartime
作者:
钟善传; 王丽; 周斌; 徐立风
作者单位：245041黄山，解放军96601部队医院检验科（钟善传、王丽、徐立风），重症医学科（周斌）
Author(s):
ZHONG Shan-chuan;  WANG Li;  ZHOU Bin ;  XU Li-feng
（1.Department of Pathology and Clinical Laboratory,2.Intensive Care Unit, 96601 Army Hospital of PLA, Huangshan 245041, Anhui,China）
关键词:
冻干血浆; 失血性休克; 液体复苏; 凝血因子
Keywords:
freeze dried plasma;  hemorrhagic shock;  fluid resuscitation;  clotting factors
分类号:
R457
DOI:
10.3969/j.issn.1672-271X.2022.03.019
文献标志码:
A
摘要:
大出血导致失血性休克是战创伤患者常见而严重的并发症，战时有将近半数的伤员死于失血性休克，院前（战场）急救给予血浆作为失血性休克患者的复苏液可降低死亡率。血浆能有效地恢复血管内容量和替代消耗的凝血因子，保持生理pH值并保护血管内皮功能。与院前（战场）环境中给予的其他复苏液（如晶体或胶体液）不同，血浆复苏的一个重要临床益处是维持平均血压所需的体积较少，不易发生因血液稀释导致的凝血病变。目前临床常用的血浆包括新鲜冰冻血浆和普通冰冻血浆。在战场环境中，需要一个质量可靠、易于携带和保存、即时能用的血浆产品，这一直是一个相当大的挑战，而冻干血浆正好具备这些优点。然而，由于存在病毒传染风险等问题，冻干血浆的发展经历了比较曲折的过程。文章主要对冻干血浆在平战时的应用历史与研究进展进行综述。
Abstract:
Hemorrhagic shock caused by massive hemorrhage is a common and serious complication of war trauma patients. Nearly half of the woundedsuccumbed to hemorrhagic shock in the war, pre-hospital (battlefield) emergency, giving plasma as resuscitation fluid for patients with hemorrhagic shock can reduce mortality. Plasma can effectively restore intravascular volume and replace consumed coagulation factors, maintain physiological pH and protect vascular endothelial function. Unlike other resuscitation (such as crystalloid and colloid resuscitation) given in pre-hospital (battlefield) environment, a clinical benefit of plasma resuscitation is the fact that it requires less volume to maintain average blood pressure and is not prone to coagulation diseases caused by hemodilution. At present, the commonly used plasma includes fresh frozen plasma (FFP) and frozen plasma (FP). In the battlefield environment, we need a plasma product which is reliable quality, easy to carry and store, and can be used immediately. Freeze dried plasma (FDP) is a fine choice according to its advantages. However, due to the risk of virus infection, the development of FDP has experienced a tortuous process. This paper summarizes the application history and research progress of FDP in peacetime and wartime.

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[2]徐东升,王发祥,卢 峰,等.乌司他汀治疗创伤性失血性休克的疗效观察[J].医学研究与战创伤救治(原医学研究生学报),2011,13(05):448.
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备注/Memo

备注/Memo:
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更新日期/Last Update: 2022-06-21