|本期目录/Table of Contents|

[1]王黎,赵卫东.幽门螺杆菌感染对胃微生物群影响的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2022,24(6):630-635.[doi:10.3969/j.issn.1672-271X.2022.06.014]
　WANG Li,ZHAO Wei-dong.Advances in the study of the effects of Helicobacter pylori infection on the gastric microbiota[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2022,24(6):630-635.[doi:10.3969/j.issn.1672-271X.2022.06.014]
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幽门螺杆菌感染对胃微生物群影响的研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第24卷
期数:
2022年6期
页码:
630-635
栏目:
综述
出版日期:
2023-01-18

文章信息/Info

Title:
Advances in the study of the effects of Helicobacter pylori infection on the gastric microbiota
作者:
王黎; 赵卫东
作者单位：671000大理，大理大学临床医学院(王黎、赵卫东)
Author(s):
WANG Li ;  ZHAO Wei-dong
(Clinical Medical College, Dali University, Dali 671000, Yunnan, China)
关键词:
幽门螺杆菌; 胃微生物群; 固有免疫; 胃癌
Keywords:
Helicobacter pylori;  gastric microbiota;  innate immunity;  gastric cancer
分类号:
R573
DOI:
10.3969/j.issn.1672-271X.2022.06.014
文献标志码:
A
摘要:
幽门螺杆菌（Helicobacter pylori, H. pylori）的致病性取决于细菌毒力、环境因素和宿主遗传易感性。在细菌毒力上，H. pylori进化出一系列机制以逃避宿主的免疫反应，这也使得H. pylori感染对胃微生物群有重要影响。另外，环境因素也对H. pylori感染起着重要作用。胃微环境主要由胃微生物群决定，影响H. pylori相关胃炎的发展以及免疫反应。胃微生物群和宿主产生了一个复杂的相互作用网络，与人体生理代谢、免疫和神经内分泌建立了密切的联系。因此，H. pylori、胃微生物群和固有免疫之间的复杂关系决定了H. pylori相关疾病的病理生理学。文章主要就幽门螺杆菌感染对正常胃微生物群和常见胃疾病胃微生物群的影响以及相关免疫机制进行综述。
Abstract:
The pathogenicity of H. pylori depends on bacterial virulence, environmental factors, and host genetic susceptibility. In terms of bacterial virulence, H. pylori has developed a range of mechanisms to evade the host’s immune response, which makes H. pylori infection important for the gastric microbiota. In addition, environmental factors also play important roles in H. pylori infection. The gastric microenvironment is largely determined by the gastric microbiota and influences the development of H. pylori-associated gastritis as well as the immune response. The gastric microbiota and the host generate a complex network of interactions that establish close connection with human physiological metabolism, immunity, and neuroendocrinology. Therefore, we hypothesize that the complex relationship between H. pylori, the gastric microbiota, and intrinsic immunity determines the pathophysiology of H. pylori-associated disease. The review focuses on a brief summary of the effects of H. pylori infection on the normal gastric microbiota and the gastric microbiota of common gastric diseases as well as the associated immune mechanisms.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金(81960363)；云南省教育厅科学研究基金研究生项目 (2022Y846)
更新日期/Last Update: 2023-01-18