|本期目录/Table of Contents|

[1]任洁,秦洁.Asprosin在性腺发育及其功能调节中的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2023,25(2):173-176.[doi:10.3969/j.issn.1672-271X.2023.02.013]
　REN Jie,QIN Jie.Research progress of Asprosin in gonadal development and its function regulation[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2023,25(2):173-176.[doi:10.3969/j.issn.1672-271X.2023.02.013]
点击复制

Asprosin在性腺发育及其功能调节中的研究进展()
分享到62.8K

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第25卷
期数:
2023年2期
页码:
173-176
栏目:
综述
出版日期:
2023-05-31

文章信息/Info

Title:
Research progress of Asprosin in gonadal development and its function regulation
作者:
任洁; 秦洁
作者单位：030012太原,山西医科大学第五临床医学院(山西省人民医院)内分泌科(任洁、秦洁)
Author(s):
REN Jie ; QIN Jie
(Department of Endocrinology, The Fifth Clinical Medical College of Shanxi Medical University, Shanxi Provincial People’s Hospital, Taiyuan 030012, Shanxi, China)
关键词:
Asprosin; 睾丸生精; 卵泡发育; 多囊卵巢综合征
Keywords:
Asprosin; testicular spermatogenesis;  follicle development; polycystic ovary syndrome
分类号:
R588
DOI:
10.3969/j.issn.1672-271X.2023.02.013
文献标志码:
A
摘要:
Asprosin是一种脂肪细胞源性细胞因子，研究表明Asprosin在糖尿病、代谢综合征、食欲调控及肿瘤的发生发展等多种生理及病理过程中发挥作用。近年来，有多项研究发现Asprosin可通过调控下丘脑-垂体-睾丸轴、调节生精过程、调节卵泡发育和成熟过程，从而调节机体性腺激素水平及其功能。多囊卵巢综合征是一种常见的内分泌妇科疾病，研究发现Asprosin对于多囊卵巢综合征的卵泡发育具有一定的调节作用。因此，Asprosin有望作为一种新的性腺发育及性腺功能评价的关键分子，成为临床治疗不孕不育症新的干预靶点。文章主要就Asprosin性腺发育及其功能调节中的研究进展进行综述。
Abstract:
Asprosin is an adipocyte-derived cytokine and plays a role in various physiological and pathological processes, such as diabetes mellitus, metabolic syndrome, appetite regulation, and tumor development. In recent years, several studies have found that Asprosin can regulate the gonadal hormone levels and their function by regulating the hypothalamic-pituitary-testicular axis, spermatogenesis process, and follicle development and maturation process.Polycystic ovarian syndrome is a common endocrine-gynecological disease. Asprosin regulates the follicular development in polycystic ovarian syndrome. Therefore, Asprosin is expected to serve as a new key molecule for gonadal development and gonad function evaluation, and become a new intervention target for the clinical treatment of infertility. Here, we review the research progress of Asprosin in gonadal development and its functional regulation.

参考文献/References:

[1]Antinozzi C, Lista M, Caponecchia L, et al. Exploratory Analysis in the Differences in Blood Serum and Seminal Plasma of Adipose-Tissue Related Peptides in Obese and Non-Obese Men and Their Correlations With Semen Parameters[J]. Front Endocrinol (Lausanne), 2021,12:681939.
[2]Alan M, Gurlek B, Yilmaz A, et al. Asprosin: a novel peptide hormone related to insulin resistance in women with polycystic ovary syndrome[J]. Gynecol Endocrinol, 2019,35(3):220-223.
[3]Deniz R, Yavuzkir S, Ugur K, et al. Subfatin and asprosin, two new metabolic players of polycystic ovary syndrome[J]. J Obstet Gynaecol, 2021,41(2):279-284.
[4]Li X, Liao M, Shen R, et al. Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases[J]. Mediators Inflamm, 2018,2018:7375294.
[5]Li X, Zhu Q, Wen Z, et al. Androgen and Luteinizing Hormone Stimulate the Function of Rat Immature Leydig Cells Through Different Transcription Signals[J]. Front Endocrinol (Lausanne), 2021,12:599149.
[6]Patel H, Bhartiya D. Direct action of FSH on testicular stem cells[J]. Stem Cell Res Ther, 2019,10(1):261.
[7]Keskin T, Erden Y, Tekin S. Intracerebroventricular asprosin administration strongly stimulates hypothalamic-pituitary-testicular axis in rats[J]. Mol Cell Endocrinol, 2021,538:111451.
[8]Duerrschmid C, He Y, Wang C, et al. Asprosin is a centrally acting orexigenic hormone[J]. Nat Med, 2017,23(12):1444-1453.
[9]Kocaman N, Kuloglu T. Expression of asprosin in rat hepatic, renal, heart, gastric, testicular and brain tissues and its changes in a streptozotocin-induced diabetes mellitus model[J]. Tissue Cell, 2020,66:101397.
[10]Romere C, Duerrschmid C, Bournat J, et al. Asprosin, a Fasting-Induced Glucogenic Protein Hormone[J]. Cell, 2016,165(3):566-579.
[11]Wei F, Long A, Wang Y. The Asprosin-OLFR734 hormonal signaling axis modulates male fertility[J]. Cell Discov, 2019,5:55.
[12]Cicek O, Kaya G, Alyuruk B, et al. The association of seminal oxidation reduction potential with sperm parameters in patients with unexplained and male factor infertility[J]. Int Braz J Urol, 2021,47(1):112-119.
[13]Balbach M, Beckert V, Hansen J N, et al. Shedding light on the role of cAMP in mammalian sperm physiology[J]. Mol Cell Endocrinol, 2018,468:111-120.
[14]Meroni SB, Galardo MN, Rindone G, et al. Molecular Mechanisms and Signaling Pathways Involved in Sertoli Cell Proliferation[J]. Front Endocrinol (Lausanne), 2019,10:224.
[15]Chiarante N, Alonso C, Plaza J, et al. Cyclic AMP efflux through MRP4 regulates actin dynamics signalling pathway and sperm motility in bovines[J]. Sci Rep, 2020,10(1):15619.
[16]Banerjee A, Anuradha, Mukherjee K, et al. Testicular glucose and its transporter GLUT 8 as a marker of age-dependent variation and its role in steroidogenesis in mice[J]. J Exp Zool A Ecol Genet Physiol, 2014,321(9):490-502.
[17]Choubey M, Ranjan A, Bora PS, et al. Role of adiponectin as a modulator of testicular function during aging in mice[J]. Biochim Biophys Acta Mol Basis Dis, 2019,1865(2):413-427.
[18]Maurya S, Singh A. Asprosin modulates testicular functions during ageing in mice[J]. Gen Comp Endocrinol, 2022,323-324:114036.
[19]Prodoehl MJ, Irving-Rodgers HF, Bonner WM, et al. Fibrillins and latent TGFbeta binding proteins in bovine ovaries of offspring following high or low protein diets during pregnancy of dams[J]. Mol Cell Endocrinol, 2009,307(1-2):133-141.
[20]Meng TG, Hu MW, Ma XS, et al. Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice[J]. Cell Death Dis， 2017，8(6):e2846.
[21]Maylem E, Spicer LJ, Batalha I, et al. Discovery of a possible role of asprosin in ovarian follicular function[J]. J Mol Endocrinol, 2021,66(1):35-44.
[22]Maylem E, Spicer LJ, Atabay EP, et al. A potential role of fibrillin-1 (FBN1) mRNA and asprosin in follicular development in water buffalo[J]. Theriogenology, 2022,178:67-72.
[23]Jones A, Shikanov A. Follicle development as an orchestrated signaling network in a 3D organoid[J]. J Biol Eng, 2019,13:2.
[24]Hatzirodos N, Bayne RA, Irving-Rodgers HF, et al. Linkage of regulators of TGF-beta activity in the fetal ovary to polycystic ovary syndrome[J]. FASEB J, 2011,25(7):2256-2265.
[25]Hatzirodos N, Hummitzsch K, Irving-Rodgers HF, et al. Transcript abundance of stromal and thecal cell related genes during bovine ovarian development[J]. PLoS One, 2019,14(3):e213575.
[26]Leonard AN, Shill AL, Thackray AE, et al. Fasted plasma asprosin concentrations are associated with menstrual cycle phase, oral contraceptive use and training status in healthy women[J]. Eur J Appl Physiol, 2021,121(3):793-801.
[27]Ouni E, Bouzin C, Dolmans MM, et al. Spatiotemporal changes in mechanical matrisome components of the human ovary from prepuberty to menopause[J]. Hum Reprod, 2020,35(6):1391-1410.
[28]Zhai B, Liu H, Li X, et al. BMP15 prevents cumulus cell apoptosis through CCL2 and FBN1 in porcine ovaries[J]. Cell Physiol Biochem, 2013,32(2):264-278.
[29]Guazzone VA, Jacobo P, Theas MS, et al. Cytokines and chemokines in testicular inflammation: A brief review[J]. Microsc Res Tech, 2009,72(8):620-628.
[30]Yu Y, He JH, Hu LL, et al. Placensin is a glucogenic hormone secreted by human placenta[J]. EMBO Rep, 2020,21(6):e49530.
[31]Zhou Z, Zhang Q, Lu X, et al. The proprotein convertase furin is required for trophoblast syncytialization[J]. Cell Death Dis, 2013,4:e593.
[32]Jiang Y, Liu Y, Yu Z, et al. Serum asprosin level in different subtypes of polycystic ovary syndrome: a cross-sectional study[J]. Rev Assoc Med Bras (1992), 2021,67(4):590-596.
[33]董思彤, 贾双硕, 王秀霞. 白脂素功能及其在多囊卵巢综合征中的作用[J]. 中国实用妇科与产科杂志, 2021,37(8):869-871.
[34]Liu YX, Zhang Y, Li YY, et al. Regulation of follicular development and differentiation by intra-ovarian factors and endocrine hormones[J]. Front Biosci (Landmark Ed), 2019,24(5):983-993.

相似文献/References:

备注/Memo

备注/Memo:
基金项目：山西省研究生教育创新项目（2022Y394）
更新日期/Last Update: 2023-07-24