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[1]樊 伟,狄留庆,宋洪涛,等.复方中药舒胸速释微丸的制备[J].医学研究与战创伤救治(原医学研究生学报),2008,10(06):406.
　FAN Wei,DI Liu-qing,SONG Hong-tao,et al.Preparation of compound Shuxiong pellets with synchronized immediate-release[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2008,10(06):406.
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复方中药舒胸速释微丸的制备()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第10卷
期数:
2008年06期
页码:
406
栏目:
出版日期:
2008-11-20

文章信息/Info

Title:
Preparation of compound Shuxiong pellets with synchronized immediate-release
文章编号:
1672-271X(2008)06-0406-03
作者:
樊 伟1; 2; 狄留庆2; 宋洪涛3; 张 伟3; 付 妍3
1.南京军区联勤部卫生部药材处，江苏南京 210016；2.南京中医药大学药学院，江苏南京 210029；3.南京军区福州总医院药学科，福建福州 350025
Author(s):
FAN Wei1; 2; DI Liu-qing2; SONG Hong-tao3; ZHANG Wei3; FU Yan3
1.Health Division, Joint Logistic Department of Nanjing Military Command, Nanjing 210016,Jiangsu,China; 2. Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu,China; 3. Department of Pharmacy,Fuzhou General Hospital of Nanjing Mi
关键词:
舒胸速释微丸; 挤出滚圆法; 同步释放
Keywords:
Shuxiong immediate-release pellets;  Extrusion-spheronization method;  Synchronized release
分类号:
R283.3
DOI:
-
文献标志码:
A
摘要:
目的 制备复方中药舒胸速释微丸，筛选速释微丸的最佳制备工艺和处方，使理化性质差异较大的各成分达到同步释放。方法 采用挤出滚圆法制备复方中药舒胸速释微丸，以阿魏酸、红花黄色素、三七总皂苷为体外溶出考察的主要指标性成分，对微丸中加入的崩解剂种类和用量、粘合剂和表面活性剂等处方因素进行筛选，并采用正交设计试验以筛选最优处方。结果 在处方中加入复合崩解剂(20％泡腾崩解剂、5％羧甲基淀粉钠)，以70%乙醇(含2%十二烷基硫酸钠)为粘合剂，可使制备的舒胸速释微丸在1 min内迅速崩解。在模拟人体胃肠道生理条件下，舒胸速释微丸中红花黄色素和三七总皂苷体外释放的f2值为77.34, 红花黄色素和阿魏酸的f2值为58.67,三七总皂苷与阿魏酸的f2值为67.83，表明三者的释放度差异无显著性。结论 通过加入复合崩解剂，可以使采用挤出滚圆法制备的舒胸速释微丸迅速崩解，从而使复方中药中理化性质差异较大的各种成分达到同步释放。
Abstract:
Objective To prepare compound Shuxiong immediate-release pellets, select the optimal process and formulation, and make various components with vastly different physicochemical properties be released synchronously. Methods Compound Shuxiong immediate release pellets were prepared by extrusion spheronization method. The safflower yellow, ferulic acid and notoginseng saponin used as the index components of release in vitro. The formulation was optimized by influential factors and orthogonal design experiment. Results The three index components were approximately released in the same time through adding compound disintegrating agents (20% effervescent disintegrating agents, 5% CMS-Na) and adhesive agents (70% ethanol, 2% SDS). Under the simulated gastrointestinal conditions, the in vitro release test of Shuxiong immediate release pellets was carried out. The value of similarity factor (f2 ) of safflower yellow and notoginseng saponin, safflower yellow and ferulic acid, and notoginseng saponin and ferulic acid was 77.34, 58.67, 67.83, respectively. The release profiles of various compositions from Shuxiong immediate release pellets showed synchronous-release characteristic and no significant difference between them. Conclusion The results showed that compound Shuxiong pellets prepared by extrusion-spheronization can be disintegrated rapidly through adding in compound disintegrating agents. Various components with vastly different physicochemical properties can be released synchronously.

参考文献/References:

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更新日期/Last Update: 2013-11-22