[1]周丽敏,于佳玥,林富林,等.小牛血去蛋白提取物对小鼠能量代谢的影响[J].医学研究与战创伤救治(原医学研究生学报),2010,12(02):104-106.
ZHOU Li-min,YU Jia-yue,LIN Fu-lin,et al.Effect of deproteinized extract of calf blood on energy metabolism in mice[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(02):104-106.
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小牛血去蛋白提取物对小鼠能量代谢的影响()
《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]
- 卷:
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第12卷
- 期数:
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2010年02期
- 页码:
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104-106
- 栏目:
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- 出版日期:
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2010-03-20
文章信息/Info
- Title:
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Effect of deproteinized extract of calf blood on energy metabolism in mice
- 文章编号:
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1672-271X(2010)02-0104-03
- 作者:
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周丽敏1; 于佳玥2; 林富林3; 张晓冬4
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1.310002 浙江杭州,浙江省军区后勤部门诊所;2.116104 辽宁大连,解放军65585部队药房;3.310004 浙江杭州,解放军117医院肛肠外科;4.200433 上海,第二军医大学基础部新药评价中心
- Author(s):
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ZHOU Li-min1; YU Jia-yue2; LIN Fu-lin3; ZHANG Xiao-dong4.
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1. Outpatient Department, Logistics of Zhejiang Military District, Hangzhou, Zhejiang 310002, China; 2. Department of Pharmacy, 65585 Unit of PLA, Dalian, Liaoning 116104, China;3. Anus-intestinal Disease Center, 117 Hospital of PLA, Hangzhou, Zhejiang 31
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- 关键词:
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小牛血去蛋白提取物; 葡萄糖; 乳酸; 小鼠
- Keywords:
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deproteinized extract of calf blood; glucose; lactic acid; mouse
- 分类号:
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R349.18
- DOI:
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- 文献标志码:
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A
- 摘要:
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目的 观察小牛血去蛋白提取物在改善小鼠大脑和心肌能量代谢的作用。方法 应用葡萄糖氧化酶法测定小鼠血糖、心肌和大脑皮层葡萄糖含量。制备小鼠急性缺氧性脑缺血模型,应用紫外分光光度法测定小鼠血液和大脑皮层中的乳酸含量。结果 小牛血去蛋白提取物可降低血糖浓度,同时升高心肌内葡萄糖含量。小鼠急性缺氧性脑缺血后,血液和皮层中乳酸浓度显著升高,小牛血去蛋白提取物可降低乳酸浓度。结论 小牛血去蛋白提取物能够改善小鼠大脑和心肌能量代谢,对于治疗缺氧性缺血疾病有一定的意义。
- Abstract:
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Objective To observe the effect of deproteinized extract of calf blood on brain and myocardial energy metabolism in mice. Methods Glucose oxidase method was used to assay the concentrations of glucose in blood, myocardium and cerebral cortex. Ultraviolet spectrophotometric method was used to detect the concertration of lactic acid in blood and cerebral cortex after the mice models of acute cerebral ischemia-hypoxia were produced. Results Compared with control group, blood glucose was decreased and glucose in myocardium increased significantly after administration of deproteinized extract of calf blood. The concentrations of lactic acid in blood and cerebral cortex of mice were increased significantly under the acute cerebral ischemia-hypoxia and were reversed after administration of deproteinized extract of calf blood. Conclusion Deproteinized extract of calf blood could be used to treat cerebral ischemia-hypoxia with the effect of improving energy metabolism of brain and myocardium.
参考文献/References:
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更新日期/Last Update:
2010-03-20