|本期目录/Table of Contents|

[1]赵海滨,张伟杰,周志华,等.MMP-7、MMP-9、VEGF-C、VEGF-D在胃癌中的表达及其临床意义[J].医学研究与战创伤救治(原医学研究生学报),2010,12(03):197-199.
　ZHAO Hai-bin,ZHANG Wei-jie,ZHOU Zhi-Hua,et al.Expression and significance of MMP-7, MMP-9, VEGF-C, and VEGF-D in gastric carcinomas[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(03):197-199.
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MMP-7、MMP-9、VEGF-C、VEGF-D在胃癌中的表达及其临床意义()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第12卷
期数:
2010年03期
页码:
197-199
栏目:
出版日期:
2010-05-20

文章信息/Info

Title:
Expression and significance of MMP-7, MMP-9, VEGF-C, and VEGF-D in gastric carcinomas
文章编号:
1672-271X(2010)03-0197-03
作者:
赵海滨1; 张伟杰2 ; 周志华1; 张建东3; 赵玲娜1
214044 江苏无锡，解放军101医院,1.病理科， 2.普外科，3.消化内科
Author(s):
ZHAO Hai-bin1; ZHANG Wei-jie2; ZHOU Zhi-Hua1; ZHANG Jian-dong3; ZHAO Ling-Na1
1.Department of Pathology, 2. Department of General Surgery, 3. Department of Gastrointestinal, 101 Hospital of PLA, Wuxi，Jiangsu 214044，China
关键词:
胃癌; 基质金属蛋白酶7; 基质金属蛋白酶9; 血管内皮生长因子-C; 血管内皮生长因子-D
Keywords:
gastric cancer;  MMP-7;  MMP-9;  VEGF-C;  VEGF-D
分类号:
R735.2
DOI:
-
文献标志码:
A
摘要:
目的 探讨基质金属蛋白酶7(MMP-7)、基质金属蛋白酶9(MMP-9)、血管内皮生长因子-C(VEGF-C)、血管内皮生长因子-D(VEGF-D)在胃癌组织中的表达及其临床意义。方法 采用免疫组织化学染色检测133例胃癌MMP-7、MMP-9、VEGF-C、VEGF-D的表达情况。结果 MMP-7、MMP-9表达与肿瘤的浸润深度、淋巴结转移、TNM分期、分化程度密切相关(P<0.05)，与肿瘤大小及患者性别无关(P>0.05)。VEGF-C和VEGF-D的表达与肿瘤分化程度、浸润程度、淋巴结转移及临床分期显著相关(P<0.05)，而与肿瘤大小及患者性别无相关性(P>0.05)。结论 MMP7、MMP9、VEGF-C、VEGF-D的表达与胃癌的生物学行为密切相关, 可作为判断胃癌进展和预后的有用指标。
Abstract:
Objective To investigate the expression and significance of MMP-7, MMP-9, VEGF-C, and VEGF-D in gastric carcinoma. Methods Immunohistochemical staining was employed to detect the expression of MMP-7, MMP-9, VEGF-C, and VEGF-D in 133 cases of gastric carcinoma. Results Expression of MMP-7 and MMP-9 were correlated with tumor invasion, lymph node metastasis, TNM staging and tumor differentiation (P<0.05), and were not associated with tumor size and patient gender (P>0.05). Expression of VEGF-C and VEGF-D was related to tumor invasion and lymph node metastasis (P<0.05), while the significant correlation between VEGF expression and tumor size and patient gender was not observed (P>0.05). Conclusion Expression of MMP-7, MMP-9, VEGF-C, and VEGF-D was tightly associated with biological behavior of gastric carcinoma, which may be an available index for predicting tumor progression and prognosis.

参考文献/References:

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备注/Memo

备注/Memo:
江苏大学2008年度临床医学科技发展基金资助项目(JLY20080086)
更新日期/Last Update: 2010-05-20