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[1]徐桂芳,张建东,赵海滨,等.E-钙粘蛋白和MMP-9在胃癌组织中的表达及其临床意义[J].医学研究与战创伤救治(原医学研究生学报),2010,12(04):308.
　XU Gui-fang,ZHANG Jian-dong,ZHAO Hai-bin,et al.Expression and significance of E-Cadherin and matrix metalloproteinase-9 in gastric carcinoma[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(04):308.
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E-钙粘蛋白和MMP-9在胃癌组织中的表达及其临床意义()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第12卷
期数:
2010年04期
页码:
308
栏目:
出版日期:
2010-07-20

文章信息/Info

Title:
Expression and significance of E-Cadherin and matrix metalloproteinase-9 in gastric carcinoma
文章编号:
1672-271X(2010)04-0308-05
作者:
徐桂芳1; 张建东2; 赵海滨2; 吴国忠2; 郑 扬2; 张伟杰2
1.210008 江苏南京，南京大学医学院附属鼓楼医院消化内科；2.214044 江苏无锡，解放军101医院
Author(s):
XU Gui-fang1;  ZHANG Jian-dong2;  ZHAO Hai-bin2; WU Guo-zhong2;  ZHENG Yang2;  ZHANG Wei-jie2
1. Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China; 2.101 Hospital of PLA, Wuxi, Jiangsu 214044, China
关键词:
胃癌; E-钙粘蛋白; 基质金属蛋白酶9; 淋巴结转移; 预后
Keywords:
gastric carcinoma;  E-Cadherin;  matrix metalloproteinase-9;  lymph node metastasis;  prognosis
分类号:
R735.2
DOI:
-
文献标志码:
A
摘要:
目的 研究E-钙粘蛋白(E-Cadherin,E-Cad)和基质金属蛋白酶9(Matrix metalloproteinase-9, MMP-9)在胃癌中的表达，及其与胃癌临床病理特征、淋巴结转移和患者预后之间的关系。方法 应用免疫组织化学方法，检测正常胃粘膜和胃癌标本的E-Cad和MMP-9表达。结果 在胃癌组织中,E-Cad呈低表达，阳性表达率为53.7%，明显低于正常胃粘膜组织(P<0.05)，其表达率与肿瘤大小、肿瘤分化、TNM分期显著相关(P<0.05)，但与淋巴结转移无明显相关性(P>0.05)；E-Cad表达阳性者，其5年生存期率较高(P<0.05)。MMP-9在胃癌组织中呈高表达(75.0%),明显高于正常组织,且与淋巴结转移、肿瘤大小、肿瘤分化、分期以及生存期显著相关(P<0.05)。结论 胃癌广泛存在E-钙粘蛋白及MMP-9表达异常，且与预后密切相关。
Abstract:
Objective To investigate the expression of E-Cadherin (E-Cad) and matrix metalloproteinase-9 (MMP-9) in gastric cancer and their relationship with clinical pathological parameters, lymph metastasis and prognosis. Methods The expressions of E-Cad and MMP-9 proteins were detected by immunohistochemistry. Results E-Cad expression was low in gastric cancer tissue compared with normal gastric mucosa. The positive expression rate was 53.7% which was significantly lower than normal gastric mucosa (P<0.05). Its expression correlated with tumor size, tumor differentiation, and TNM stage (P<0.05), but no significant correlation with lymph node metastasis was found (P>0.05). The 5-year survival in patients with positive E-Cad expression was significantly longer than those with negative expression (P<0.05). MMP-9 in gastric cancer tissues showed significantly higher expression(75.0%) than in normal tissue (P<0.05). Its expression was related to lymph node metastasis, tumor size, tumor differentiation, TNM stage and survival (P<0.05). Conclusion The expression of E-Cad and MMP-9 is related to prognosis of gastric carcinoma.

参考文献/References:

[1]Kim JH, Kim MA, Lee HS, et al. Comparative analysis of protein expressions in primary and metastatic gastric carcinomas［J］. Hum Pathol， 2009, 40(3):314-322.
[2］Humar B, Blair V, Charlton A, et al. E-cadherin deficiency initiates gastric signet-ring cell carcinoma in mice and man［J］. Cancer Res,2009,69(5):2050-2056.
[3］Muretto P, Ruzzo A, Pizzagalli F, et al. Endogastric capsule for E-cadherin gene (CDH1) promoter hypermethylation assessment in DNA from gastric juice of diffuse gastric cancer patients［J］. Ann Oncol,2008,19(3):516-519.
[4］Kim JH, Park JM, Jung CW, et al. The significances of lymph node micrometastasis and its correlation with E-cadherin expression in pT1-T3N0 gastric adenocarcinoma［J］. J Surg Oncol,2008,97(2):125-130.
[5］张建军,刘志明. MMP-9,TIMP-1和Ⅳ型胶原在甲状腺癌中的表达及其临床意义［J］.中国普通外科杂志,2007,16(1):81-84.
[6］Czyzewska J, Guzińska-Ustymowicz K, Kemona A, et al. The expression of matrix metalloproteinase 9 and cathepsin B in gastric carcinoma is associated with lymph node metastasis, but not with postoperative survival［J］. Folia Histochem Cytobiol， 2008,46(1):57-64.
[7］赵凤娟,康春生,崔小伟,等.基质金属蛋白酶-9、血管内皮生长因子和增殖细胞核抗原在胃腺癌表达的相关性及临床意义［J］.中华内科杂志,2009,48(2):114-117.
[8］Zhao ZS, Wang YY, Ye ZY, et al. Prognostic value of tumor-related molecular expression in gastric carcinoma［J］.Pathol Oncol Res,2009,15(4):589-596.
[9］Tan SY, Wang JY, Shen L, et al. Relationship between preoperative staging by endoscopic ultrasonography and MMP-9 expression in gastric carcinoma［J］.World J Gastroenterol,2007,13(14):2108-2112.

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备注/Memo

备注/Memo:
-
更新日期/Last Update: 2010-07-20