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[1]黄亚莉,潘溪柳,谷 威,等.健康老年人血管内皮舒张功能障碍的相关性研究[J].医学研究与战创伤救治(原医学研究生学报),2011,13(01):17-19.
　HUANG Ya-li,PAN Xi-liu,GU Wei,et al.Research on endothelium-dependent vasorelaxation in the elderly[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(01):17-19.
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健康老年人血管内皮舒张功能障碍的相关性研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第13卷
期数:
2011年01期
页码:
17-19
栏目:
出版日期:
2011-01-20

文章信息/Info

Title:
Research on endothelium-dependent vasorelaxation in the elderly
文章编号:
1672-271X(2011)01-0017-03
作者:
黄亚莉; 潘溪柳; 谷 威; 沈若宇
210081 上海，解放军411医院干部病房科
Author(s):
HUANG Ya-li; PAN Xi-liu; GU Wei; SHEN Nuo-yu
Carder’s Ward，411 Hospital of PLA, Shanghai 200081, China
关键词:
肱动脉; 老年人; 血管内皮舒张功能; 前列环素
Keywords:
brachial arteries;  aging;  vascular endothelium dysfunction;  prostaglandin
分类号:
R331.321
DOI:
-
文献标志码:
A
摘要:
目的 研究健康老年人和健康青年人之间肱动脉血管内皮舒张功能变化，并分析与血管内皮舒张因子的相关性。方法 100名志愿者分两组，健康老年组50名和健康青年组50名，每组男、女各25名。采用超声对肱动脉基础内径、血管内皮依赖性舒张功能(EDV)和硝酸甘油介导的血管内皮非依赖性舒张功能(NEDV)测定。并检测两组血清中前列环素(PGI2)终产物6-Kote-PGF1a 和血栓素终产物TXB2的含量。 结果 与青年人相比，老年人肱动脉基础内径增宽(P<0.01)，EDV和NEDV明显降低(P<0.05)；6-Kote-PGF1a生成减少(P<0.01)，TXB2/6-Kote-PGF1a (T/P)比值升高(P<0.01)；EDV与6-Kote-PGF1a含量呈正相关，EDV与年龄、T/P比值均呈负相关。结论 健康老年人血管EDV和NEDV舒张功能下降，与血清中舒血管因子PGI2含量下降有关。
Abstract:
Objective The alteration of brachial artery diastolic function in healthy aged and young people was studied to analyze the relation to endothelium-derived relaxing factor. Methods A case control study was employed, which enrolled 50 health senior citizens (group A) and 50 health young adults (group B) of Han population in Shanghai, China. The endothelium-dependent vasorelaxation (EDV) and nitroglycerin-induced endothelium-independent vasorelaxation (NEDV) in brachial arteries were determined by Color Doppler Ultrasound. Serum 6-Kote-PGF1a and TXB2 were measured. Results The interior diameter of brachial arterials was enlarged (P<0.01) and EDV and NEDV were decreased (P<0.05) in the elderly, compared to those in the young. Accordingly, serum were remarkably reduced and the ratios of TXB2/6-Kote-PGF1a (T/P) was significantly inelevated in senile subjects (P<0.01 vs. young adult, respectively). Moreover, the reduction of EDV was positively correlated with the decrease in 6-Kote-PGF1a and negatively correlated with EDV the ratio of T/P. Conclusion Our results suggest that endothelium-dependent and-independent vasorelaxation were impaired in health older people, which was attributable to decrease in the bioavailability of prostaglandin in aging.

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备注/Memo

备注/Memo:
南京军区医学科技创新课题项目(08A006)
更新日期/Last Update: 2011-01-20