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[1]曹江晨,雷军平,李路军,等.辛伐他汀对变态反应性脑脊髓炎小鼠INF-γ 和IL-10表达的影响[J].医学研究与战创伤救治(原医学研究生学报),2011,13(01):24-27.
　CAO Jiang-chen,LEI Jun-ping,LI Lu-jun,et al.Effect of simvastatin on expression of INF-γ and IL-10 in mice with allergic encephalomyelitis[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(01):24-27.
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辛伐他汀对变态反应性脑脊髓炎小鼠INF-γ 和IL-10表达的影响()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第13卷
期数:
2011年01期
页码:
24-27
栏目:
出版日期:
2011-01-20

文章信息/Info

Title:
Effect of simvastatin on expression of INF-γ and IL-10 in mice with allergic encephalomyelitis
文章编号:
1672-271X(2011)01-0024-04
作者:
曹江晨1; 雷军平2; 李路军3; 陈光勇4
1.214063 江苏无锡， 解放军73801部队门诊部;2.200433 上海,第二军医大学附属长海医院心内科；3.214063 江苏无锡，南京军区联勤部无锡干休所卫生所；4.351100 福建莆田，南京军区福州总医院第一附属医院
Author(s):
CAO Jiang-chen1;  LEI Jun-ping2;  LI Lu-jun3;  CHEN Guang-yong4
1.Out-patient Department of 73801 army, PLA, Wuxi, Jiangsu 214063，China；2.Department of Cardiology, Changhai Hospital Affiliated to the Second Military Medical University, Shanghai 200433，China；3. Joint Logistics Department of the Nanjing Military Area Command,retired cadres health center,wuxi,Jiangsu 214063，China；4. The First Affiliated Hospital of Fuzhou General Hospital, Nanjing Military Area Command, Putian,Fujian 351100，China
关键词:
多发性硬化; 实验性变态反应性脑脊髓炎(EAE); 辛伐他汀; INF-γ; IL-10
Keywords:
multiple sclerosis; experiment allergic encephalomyelitis; simvastatin; INF-γ; IL-10
分类号:
R744.5
DOI:
-
文献标志码:
A
摘要:
目的 研究辛伐他汀(Simvastatin)对实验性变态反应性脑脊髓炎(experiment allergic encephalomyelitis，EAE)小鼠肿瘤坏死因子-γ(INF-γ)和白细胞介素-10(IL-10)表达的影响，探讨该药物对EAE保护作用的免疫调节机制。方法 通过皮下注射MOG33-55肽段诱导小鼠急性EAE模型，实验分为EAE给药组、EAE对照组和正常对照组。观察各组小鼠体重等变化，测定EAE发病高峰期血清、培养的单核细胞及脾细胞培养上清液的INF-γ和IL-10水平。结果 辛伐他汀能降低EAE小鼠的发病率，减轻了症状的严重程度，并能显著降低EAE小鼠血清、单个核细胞及脾细胞培养上清中INF-γ水平，升高IL-10水平。结论 辛伐他汀可能通过其抑制INF-γ和上调IL-10的表达，调节免疫状态，从而对小鼠EAE起到保护作用。
Abstract:
Objective To investigate the effect of simvastatin on expression of INF- and IL-10 in mice with experiment allergic encephalomyelitis (EAE), and the immunomodulatory mechanism for protection of allergic encephalomyelitis. Methods EAE was induced in C57BL/6J mice by immunization with MOG33-55. Mice were randomly divided into three groups: EAE simvastatin treatment group, EAE sham treatment group, and normal control group. The clinical assessment of EAE was performed daily. The levels of INF-γ and IL-10 in the serum, and the cell suspension of cultured mononuclear cell (MNC) or spleen cell were analyzed by ELISA. Results Simvastatin reduced the incidence and severity of EAE, which was accomplished by the inhibited expression of INF-γ and enhanced expression of IL-10. Conclusions Simvastatin might ameliorated EAE through an immunomodulatory effect that inhibits the expression of INF-γ and enhances the expression of IL-10．

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更新日期/Last Update: 2011-01-20