|本期目录/Table of Contents|

[1]刘亚锋,潘苏华.复方银杏叶胶囊对肝损伤大鼠CYP2E1、CYP3A4的影响[J].医学研究与战创伤救治(原医学研究生学报),2011,13(02):100-103.
　LIU Ya-feng,PAN Su-hua.Influence of the compound Ginkgo Biloba on CYP2E1 and CYP3A4 enzyme activity in hepatic injuried rats[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(02):100-103.
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复方银杏叶胶囊对肝损伤大鼠CYP2E1、CYP3A4的影响()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第13卷
期数:
2011年02期
页码:
100-103
栏目:
出版日期:
2011-03-20

文章信息/Info

Title:
Influence of the compound Ginkgo Biloba on CYP2E1 and CYP3A4 enzyme activity in hepatic injuried rats
文章编号:
1672-271X(2011)02-0100-04
作者:
刘亚锋; 潘苏华
210046 江苏南京，南京中医药大学
Author(s):
LIU Ya-feng;  PAN Su-hua
Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210046, China
关键词:
酒精性肝损伤; 银杏叶提取物; CYP2E1; CYP3A4
Keywords:
alcoholic hepatocyte injury;  Ginkgo biloba extract;  CYP2E1;  CYP3A4
分类号:
R969.1
DOI:
-
文献标志码:
A
摘要:
目的 研究复方银杏叶胶囊(CGB)对酒精性肝损伤大鼠CYP2E1、CYP3A4活性的影响。方法 正常组和酒精性肝损伤模型组均以CGB[(250 mg/(kg·d)]灌胃，分别在灌胃CGB前及灌胃1周后，灌胃探针药氯唑沙宗(50 mg/kg)及氨苯砜(20 mg/kg)，于探针药灌后24 h内不同时间点采血，测定各探针药血药浓度。结果 灌胃CGB前，模型组氯唑沙宗和氨苯砜的AUC0-24、Cmax均显著低于正常组(P<0.05或P<0.01)。灌胃CGB后，模型组氯唑沙宗和氨苯砜的AUC0-24、Cmax均较灌胃前显著升高(P<0.05或P<0.01)；且氯唑沙宗的t1/2灌胃CGB后明显高于灌胃前(P<0.05)。结论 CGB能够明显抑制酒精性肝损伤大鼠CYP2E1、CYP3A4酶活性。
Abstract:
Objective To observe the effect of the compound Ginkgo Biloba (CGB) on CYP2E1 and CYP3A4 activity in hepatic alcohol-injuried rats. Methods CGB was orally administrated to the normal and the alcohol-injured hepatic injury model rats. Two group rats underwent 2-cycle pharmacokinetic experiments before and after being treated with CGB(250 mg·kg-1·d-1) for 7 days, in which the rats were concomitantly administered Chlorzoxazone (50 mg/kg) and Dapsone (20 mg/kg) by gastrogavage followed by blood-withdrawing from orbital bleeding at different intervals within 24 hours. Results Before being treated with CGB, compared with normal control group, the AUC0-24 and Cmax of Chlorzoxazone and Dapsone in the model group were decreased significantly (P<0.05, P<0.01). However, the AUC0-24, and Cmax of Chlorzoxazone and Dapsone after being treated with CGB in the model group were both larger than those before treatment(P<0.05, P<0.01), and the t1/2 of Chlorzoxazon than that that before treatment. Conclusion CGB could inhibit activities of CYP2E1 and CYP3A4 in alcohol-injuried rats.

参考文献/References:

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备注/Memo

备注/Memo:
江苏省中医局基金项目(H-024)
更新日期/Last Update: 2011-03-20