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[1]冷冬妮,刘 志,刘英娜,等.膀胱尿路上皮癌伴腺性分化临床病理观察[J].医学研究与战创伤救治(原医学研究生学报),2011,13(06):512-514.
　LENG Dong-ni,LIU Zhi,LIU Ying-na,et al.Clinicopathological observation of urothelial carcinoma of the bladder with glandular differentiation[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(06):512-514.
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膀胱尿路上皮癌伴腺性分化临床病理观察()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第13卷
期数:
2011年06期
页码:
512-514
栏目:
出版日期:
2011-11-20

文章信息/Info

Title:
Clinicopathological observation of urothelial carcinoma of the bladder with glandular differentiation
文章编号:
1672-271X(2011)06-0512-03
作者:
冷冬妮1; 刘 志2; 刘英娜1; 闵 慧1; 王 珺1
1.210002 江苏南京，解放军454医院病理科；2.243000 安徽马鞍山，马鞍山市人民医院病理科
Author(s):
LENG Dong-ni1; LIU Zhi2; LIU Ying-na1; MIN Hui1; WANG Jun1
1.Department of Pathology,454 Hospital of PLA,Nanjing,Jiangsu 210002，China;2.Department of Pathology,the People’s Hospital of Maanshan,Maanshan,Anhui 243000，China
关键词:
膀胱肿瘤; 尿路上皮癌; 病理学
Keywords:
tumor of the bladder;  urothelial carcinoma;  pathology
分类号:
R730.2
DOI:
-
文献标志码:
A
摘要:
目的 探讨膀胱尿路上皮癌伴腺性分化的病理诊断与鉴别。方法 采用HE和免疫组化(EnVision法)观察10例膀胱尿路上皮癌伴腺性分化的形态学及免疫组化特征。结果 10例肿瘤平均直径为2.5 cm，呈菜花状、息肉状、蕈伞状或溃疡状。组织学以尿路上皮癌与腺性成分混合为特征。免疫组化CKpan阳性(10/10)、p63阳性(10/10)，Ki-67阳性(10/10，20%～60%)，p53阳性(10/10，10%～20%)，PSA、P504S、CgA、Syn及SMA均阴性。结论 该肿瘤是一种少见的膀胱肿瘤，需与膀胱其他多种疾病鉴别。
Abstract:
Objective To study the pathological diagnosis and differential diagnosis of urothelial carcinoma of the bladder with glandular differentiation. Methods The morphological and immunohistological features of ten cases of urothelial carcinoma of the bladder with glandular differentiation were investigated with H&E staining and EnVision immunostaining. Results The tumors were mean diameter 2.5 cm in size,cauliflower-like,polypoid,mushroom-like and ulcer-like in naked eye. Histologically,all cases showed presence of urothelial carcinoma and glandular component. Immunohistochemically,the tumors were positive for CKpan(10/10),p63(10/10),Ki-67(10/10，20%～60%) and p53(10/10,10%～20%),but negative for PSA,P504S,CgA,Syn and SMA. Conclusion Urothelial carcinoma of the bladder with glandular differentiation is rare in clinic. It should be differentiated from many other diseases of bladder.

参考文献/References:

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[3]Chalasani V,Chin JL,Izawa JI. Histologic variants of urothelial bladder cancer and nonurothelial histology in bladder cancer [J]. Can Urol Assoc J,2009,3(Suppl 4):S193-S198.
[4]丁华野，皋岚湘，田玉旺. 腺性膀胱炎与膀胱移行细胞癌关系的形态学观察[J].诊断病理学杂志，1994，1(2):83-84.
[5]Radopoulos D,Kalyvas K,Kotakidou R. Microcystic transitional cell carcinoma of the urinary bladder [J]. Int Urol Nephrol,2005,37(2):291-293.
[6]Tamboli P,Mohsin SK,Hailemariam S,et al. Colonic adenocarcinoma metastatic to the urinary tract versus primary tumors of the urinary tract with glandular differentiation: a report of 7 cases and investigation using a limited immunohistochemical panel [J]. Arch Pathol Lab Med,2002,126(9):1057-1063.
[7]Miller JS,Epstein JI.Noninvasive urothelial carcinoma of the bladder with glandular differentiation-report of 24 cases [J].Am J Surg Pathol,2009，33(8):1241-1248.
[8]Rodríguez-Alonso A,Pita-Fernández S,González-Carreró J,et al. Multivariate analysis of suivival,recurrence,progression and development of mestastasis in T1 and T2a transitional cell bladder carcinoma [J].Cancer,2002,94(6):1677-1684.
[9]Erdemir F,Tunc M,Ozcan F,et al. The effect of squamous and/or glandular differentiation on recurrence,progression and survival in urothelial carcinoma of bladder [J]. Int Urol Nephrol,2007,39(3):803-807.

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备注/Memo

备注/Memo:
-
更新日期/Last Update: 2011-11-20