|本期目录/Table of Contents|

[1]吴 艳,石 尧,薛春燕.激光共焦显微镜观察真菌性角膜炎治疗效果的研究[J].医学研究与战创伤救治(原医学研究生学报),2012,14(03):227-229.
　WU Yan,SHI Yao,XUE Chun-yan..The imaging investigation of the treatment of fungal keratitis by laser confocal microscopy[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(03):227-229.
点击复制

激光共焦显微镜观察真菌性角膜炎治疗效果的研究()
分享到62.8K

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第14卷
期数:
2012年03期
页码:
227-229
栏目:
出版日期:
2012-05-22

文章信息/Info

Title:
The imaging investigation of the treatment of fungal keratitis by laser confocal microscopy
文章编号:
1672-271X(2012)03-0227-03
作者:
吴 艳; 石 尧; 薛春燕
210002 江苏南京，南京军区南京总医院眼科
Author(s):
WU Yan; SHI Yao; XUE Chun-yan.
Department of Ophthalmology，Nanjing General Hospital of Nanjing Military Command，Nanjing，Jiangsu 210002，China
关键词:
激光共焦显微镜; 真菌性角膜炎; 那他霉素眼液; 菌丝
Keywords:
laser confocal microscopy;  fungal keratitis;  natamycin eyedrop;  hypha
分类号:
R772.21
DOI:
-
文献标志码:
A
摘要:
目的 研究激光共焦显微镜对观察真菌性角膜炎治疗过程中病情转归的意义。方法 对42例(42眼)经门诊诊断为真菌性角膜炎的患眼，临床使用那他霉素眼用混悬液抗真菌治疗，治疗前及治疗后1周、1月分别行患眼的激光共焦显微镜检查，观察真菌菌丝生长情况。并根据临床反应判断治疗结果。结果 治疗后病灶处菌丝密度明显减少，甚至消失，周边炎性细胞浸润减少，基质透亮度增加，胶原纤维增生，组织呈瘢痕化增生。治疗前，激光共焦显微镜下42例中37例见菌丝分布(88.1%)，抗真菌治疗1周后42例菌丝阳性为26例(61.9%)，1月后患眼菌丝阳性为9例(21.4%)，结果差异具有统计学意义(P<0.05)。最终治愈28例(66.7%)，好转9例(21.4%)，无效5例(11.9%)。最终有效率达88.1%。其中无效5例中均为菌丝阳性，好转中菌丝阳性为4例，但密度较治疗前明显减少。结论 激光共焦显微镜对观察真菌性角膜炎病情的转归具有临床意义。
Abstract:
Objective To observe the treatment of the fungal keratitis by laser confocal microscope.Methods Fourty-two cases (42 eyes)suffered with fungal keratitis were treated with natamycin eyedrop.Laser confocal microscope scanning was given before and after the treatment 1 week and 1 month for observation of the existence of the hypha.Results The hypha and the inflammatory cells were decreased,the stroma was lighten,and the corneas became scarring after the treatment.The hypha was found in 37 out of 42 cases before the treatment.There were 26 cases had hypha 1 week after treatment,and 9 cases had hypha 1 month after treatment,which showed the statistical significance (P<0.05).The final effective power rate was 88.1%,which curing 28 cases,improving 9 cases and no-effective 5 cases.The hypha was found in all the no effective cases and 4 of improving cases,but the latter showed a decreasing density.Conclusion The laser confocal microscope can be used for observing the treatment of the fungal keratitis in clinic.

参考文献/References:

[1]单秀水，肖凤枝，吴永刚，等.真菌性角膜炎病原学诊断[J].中国实用眼科杂志，2006，24(8):828-829.
[2]洪原城,黄鑫成,黄种杰,等.老年肺真菌感染患者检测葡聚糖的临床意义[J].东南国防医药，2011,13(1):28-30.
[3]Srinivasan M.Fungal keratitis[J].Curr Opin Ophthalmol,2004,15(4):321-327.
[4]何 彦，潘志强.真菌性角膜炎诊治进展[J].中华眼科杂志,2009,45(9):860-864.
[5]石 尧，吴 艳，薛春燕，等.激光角膜共焦显微镜观察真菌性角膜炎的研究[J].医学研究生学报，2009,22(4):380-382.
[6]Sonego-Krone S,Sanchez-Di D,Martino D,et al.Clinical results of topical fluconazole for the treatment of filamentous fungal keratitis[J].Graefes Arch Clin Exp Ophthalmol,2006,244(7):782-787.
[7]袁东兵，袁士超，于明玉，等.那他霉素滴眼液治疗真菌性角膜炎[J].海南医学院学报，2009,15(9):1128-1132.
[8]王志昕，王智群，罗时运，等.眼部真菌感染的病原学及体外药物敏感性分析[J].眼科研究，2007，25(2):145-148.
[9]Lalitha P,Shapiro BL,Srinivasan M,et al.Antimic robial susceptibility of fusarium,aspergillus,and other filamentous fungi isolated from keratitis[J].Arch Ophthalmol,2007,125(6):789-793.
[10]Ledbetter EC,Patten VH,Scarlett JM,et al.In vitro susceptibility patterns of fungi associated with keratomycosis in horses of the northeastern United States:68 cases(1987-2006)[J].J Am Vet Med Assoc,2007,231(7):1086-1091.
[11]Garcia-de-Lomas J,Fons MA,Nogueira JM,et al.Chemotherapy of aspergillus fumigatus keratitis:an experimental study[J].Mycopathologia,1985,89(3):135-138.

相似文献/References:

备注/Memo

备注/Memo:
-
更新日期/Last Update: 2012-05-20