|本期目录/Table of Contents|

[1]陈 勇,胡毓安.乙型肝炎病毒表面大蛋白的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2013,15(04):381-383.[doi:10.3969/j.issn.1672-271X.2013.04.020]
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乙型肝炎病毒表面大蛋白的研究进展()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第15卷
期数:
2013年04期
页码:
381-383
栏目:
综述
出版日期:
2013-08-05

文章信息/Info

Title:
-
作者:
陈 勇 胡毓安
210002 江苏南京,南京军区南京总医院临床中心实验科
Author(s):
-
关键词:
乙型肝炎病毒表面大蛋白 生物学功能 临床应用
Keywords:
-
分类号:
R373.21
DOI:
10.3969/j.issn.1672-271X.2013.04.020
文献标志码:
A
摘要:
临床上主要以肝功能,乙肝病毒e抗原(HBeAg),HBV DNA作为主要指标监测乙型肝炎患者体内病毒复制与抗病毒治疗效果,但都有局限性。尤其对HBeAg阴性的慢性乙型肝炎患者缺乏快速准确反映其体内乙型肝炎病毒复制与疗效的指标。很多研究证明,乙型肝炎病毒表面大蛋白(Hepatitis B virus large surface protein, HBV-LP)能够很好地反映HBV的复制情况。本文结合国内外相关研究文献,对HBV-LP的研究进展作一综述。
Abstract:
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参考文献/References:

[1] 成 均,孙长贵,戴玉柱,等.驻浙部队HBV感染情况及低浓度HBsAg流行病学调查[J].东南国防医药,2009,11(4):298-301.
[2] 时连华,郑纪山.乙型肝炎病毒血清亚型的研究进展[J].东南国防医药,2003,5(5):398-399.
[3] McMahon BJ.The natural history of chronic hepatitis B virus infection[J].Hepatology,2009,4(9):45-55.
[4] Holness G,Carriero DC,Dieterich DT.Hepatitis B the rapies and antiviral nesistance detection and management[J].Expert Rew Gastroenterol Hepatol,2009,3(7):693-699.
[5] Shi YH,Shi CH.Molecular characteristics and stages of chronic hepatitis B virus infection[J].World Gastroenterol,2009,1(5):3099-3105.
[6] 骆抗先.乙型肝炎基础和临床[M].3版.北京:人民卫生出版社,2006:245-259.
[7] Stampler MJ,Krauss RM,Ma J,et al.A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction[J].JAMA,1996,276(11):882-888.
[8] Lambert C,Mann S,Prange R.Assessment of determinants affecting the dual topology of hepadnaviral large envelope proteins[J].J Gener Virolo,2004,85(5):1221-1225.
[9] Chai N,Gudima S,Chang J,et al.Immunoadhesins containing pre-S domains of hepatitis B virus large envelope protein are secreted and inhibit virus infection[J].J Viral,2007,81(10):4912-4915.
[10 ] Patient R,Hourioux C,Sizaret PY,et al.Hepatitis B vires subviral envelope particle morphogonesis and intracellular trafficking[J].J Viral,2007,81(8):3842-3845.
[11] Lambert C,Mann S,Prange R.Assessment of determinants affecting the dual topology of hepadnaviral large envelope proteins[J].J Gen Virol,2004,85(5):1221-1223.
[12] Bruss V.Envelopment of the hepatitis B virus nucleocapsid[J]. Virus research,2004,106(2):199-209.
[13] Bang G,Kim KH,Guarnieri M,et al.Effect of mutating the two cysteines required for HBe anfigenieity on hepatitis B virus DNA replication and virion secretion[J].Virology,2005,332(1):216-224.
[14] Brass V,Viehf K.Functions of the internal Pro-S domain of large surface protein in hepatitis B virus particle motphogenesis[J].J Virol,1995,69(11):6652-6657.
[15] 兰 萌,暴旭广,莫炳强,等.乙型肝炎病毒大蛋白含量与病毒复制的关系[J].广东医学,2009,30(1):87-88.
[16] Kim HS,Ryu CJ,Hong HJ.Hepatitis B virus preS1 functions as a transcriptional activation domain[J].J Gen Virol,1997,78(Pt 5):1083-1086.
[17] Lambert C,Mann S,Prange R. Assessment of determinants affecting the dual topology of hepadnaviral large envelope proteins[J].J Gener Virol,2004,8(Pt 5):1221-1225.
[18] Bruns M,Miska S,Chassot S,et al.Enhancement of hepatitis B virus infection by noninfectious sub viral particles[J].Virol,1998,72(2):1462-1468.
[19] Bruss V.Envelopment of t he hepatitis B virus nucleocapsid[J].Virus Res,2004,10(6):199-209.
[20] Foo NC,Ahn B,Ma X,et al.Cellular vacuolization and apoptosis induced by hepatitis B virus large surface protein[J].Hepatology, 2002,6(8):1400-1407.
[21] Bruss V,Vieluf K.Functions of the internal pre-S domain of the large surface protein in hepatitis B virus particle morphenesis[J].Virol,1995,69(11):6652-6657.
[22] 成 军,刘 妍,洪 源,等.羧基末端截短型乙型肝炎病毒表面抗原中蛋白反式激活作用的研究[J].世界华人消化杂志,2003,11(4):1245-1247.
[23] 成 军.慢性病毒性肝炎发病机制的分子生物学研究[J].世界华人消化杂志,2002,10(3):125-128.
[24] 刘 妍,成 军,陆荫英,等.乙型肝炎病毒蛋白反式激活基因的研究[J].世界华人消化杂志,2002,10(3):217-219.
[25] Hartman-Stuhler C,Prange R.Hepatitis B virus large envelope protein interacts with g2-Adaptin,a clathrin adaptor-related protein[J].Virol,2001,7(5):5343-5351.
[26] HU YP,Yao YC,Li JX,et al.The cloning of 3 truncated preS/S gene from HBV genomic DNA and its expression in transgenic mice[J].Gastroenterol,2000,6(4):734-737.
[27] 侯 玲,徐晚枫.乙型肝炎(HBV)感染临床治愈后的长期预后[J].日本医学介绍,2004,25(11):515-516.
[28] Hamassak K,Nakata K,Nagagama Y,et al.Chang in prevalence of HBeAg negative mutant hepatitis B virus during the course chronic hepatitis B[J].Hepatology,1994,20(5):8-14.
[29] 彭建明,李金明.病毒样颗粒在免疫测定中的应用研究进展[J].中华检验医学杂志,2005,2(8):214-216.
[30] 中华医学会传染病与寄生虫病学分会、肝病学分会联合修订.病毒性肝炎防治方案[J].肝脏,2000,16(2):4-7.
[31] Paran N,Cooper A,Shaul Y.Interaction of hepatitis B virus with cells[J].Rev Medviml,2003,1(3):137-143.
[32] 毛远丽,李伯安,马洪滨,等.乙肝患者外膜蛋白血清学检测及对于判定HBV DNA复制的意义[J].中华实验和临床病毒学杂志,2006,20(3):276-278.
[33] 乐爱平,鞠北华,王 文,等.乙肝病毒大蛋白在乙型肝炎诊治中的临床意义[J].世界华人消化杂志,2006,14(16):1578-1581.
[34] 魏红山,黄玉波,宋淑静,等.e抗原阴性慢性乙型肝炎患者血清表面抗原大蛋白水平与乙型肝炎病毒DNA之间的关系[J].中华肝脏病杂志,2006,14(7):543-546.
[35] 陈 勇,胡毓安,袁大莉,等.乙型肝炎病毒表面大蛋白的检测及其临床应用[J].东南国防医药,2012,14(6):525-527.

相似文献/References:

[1]陈 勇,胡毓安,袁大莉,等.乙型肝炎病毒表面大蛋白的检测及其临床应用[J].医学研究与战创伤救治(原医学研究生学报),2012,14(06):525.
 CHEN Yong,HU Yu-an,YUAN Da-li,et al.Detection of HBV large surface protein and its clinical significance in patients with hepatitis B[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(04):525.

备注/Memo

备注/Memo:
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更新日期/Last Update: 2013-08-05