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[1]徐小平,张绍明,汪 雷,等.奥曲肽治疗普胸术后胸腔渗液疗效观察[J].医学研究与战创伤救治(原医学研究生学报),2013,15(05):458-460.[doi:10.3969/j.issn.1672-271X.2013.05.009]
　XU Xiao-ping,ZHANG Shao-ming,WANG Lei,et al.The efficacy of octreotide in the treatment of pleural effusion after thoracic surgery[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2013,15(05):458-460.[doi:10.3969/j.issn.1672-271X.2013.05.009]
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奥曲肽治疗普胸术后胸腔渗液疗效观察()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第15卷
期数:
2013年05期
页码:
458-460
栏目:
出版日期:
2013-10-20

文章信息/Info

Title:
The efficacy of octreotide in the treatment of pleural effusion after thoracic surgery
作者:
徐小平; 张绍明; 汪 雷; 吴海波; 张 珩
200052上海，解放军455医院心胸外科
Author(s):
XU Xiao-ping; ZHANG Shao-ming; WANG Lei; WU Hai-bo; ZHANG Heng
Department of Cardiothoracic Surgery,455 Hospital of PLA,Shanghai 200052,China
关键词:
奥曲肽; 胸腔渗液; 普胸手术
Keywords:
octreotide;  thoracic effusion;  thoracic surgery
分类号:
R561.3
DOI:
10.3969/j.issn.1672-271X.2013.05.009
文献标志码:
A
摘要:
目的 观察奥曲肽治疗普胸术后胸腔渗液的疗效。方法 将普胸术后胸腔渗液76例随机分为观察组44例和对照组32例，对照组仅给予常规治疗，观察组在常规治疗同时皮下注射奥曲肽0.1 mg，1次/8 h。比较两组治疗有效率及用药前后胸液量变化。结果 观察组有效率为88.6%，发生不良反应1例（2.27%），对照组有效率28.1%，两组疗效比较有显著差异（P<0.01）。用药前两组患者胸液量比较无显著差异（P>0.05），用药后第3天开始胸液量比较有显著差异（P<0.01）。结论 奥曲肽应用于治疗普胸术后胸腔渗液安全有效、操作简便。
Abstract:
Objective To monitor the efficacy of octreotide in the treatment of pleural effusion after thoracic surgery.Methods The treatment group consisted of 44 patients with pleural effusion fitting the inclusion criteria.Subcutaneously injected Octreotide 0.1 mg was administered every 8 hours in additional to basic treatment.The control group consisted of 32 patients selected during the same period who were given only basic treatment.Comparisons were made between the two groups for differences in treatment efficacy and in quantity of drainage as measured before and after the administration of pharmacotherapy.Results The effective rate of treatment in the treatment group was 88.6%.Only 1 side effect was observed (2.27%).The effective rate of treatment in the control group was 28.1%.The difference in effective rates between the two groups was statistically significant(P<0.01).From the third day after treatment,a statistically significant difference was observed between the two groups in terms of the amount of pleural effusion (P<0.01),while no difference in pleural effusion was seen before treatment between two groups (P>0.05).Conclusion Octreotide is an effective,safe,and simple option for the treatment of pleural effusion after thoracic surgery.

参考文献/References:

[1]汪 雷,颜 涛,赵铁军，等.奥曲肽在肺癌切除术后胸腔渗液治疗中的应用观察［J］.山东医药，2011,51(2):54-55.
[2］孙衍庆,宋鸿钊,邱蔚六.现代手术并发症学［M］.西安：世界图书出版公司,2003：488.
[3］潘铁成,殷桂林.胸心外科急症和并发症［M］.北京：人民卫生出版社,2006：283-284.
[4］陈新谦,金有豫,汤 光.新编药物学［M］.15版.人民卫生出版社,2004：479.
[5］黄 普.醋酸奥曲肽联合盐酸普萘洛尔治疗肝硬化门静脉高压致上消化道出血临床观察［J］.中华实用诊断与治疗杂志，2013,27(4):387-388.
[6］伏爱国,郝 波,任清华,等.奥曲肽辅助治疗肝硬化食管胃底静脉曲张破裂出血疗效分析［J］.中华实用诊断与治疗杂志，2009,23(1):68-69.
[7］Ripamonti CI.Malignant bowel obstruction: tailoring treatment to individual patients［J］.J Support Oncol，2008,6(3):114-115.
[8］张南征,马晓燕.奥曲肽对胃癌细胞株SGC7901生长调控作用的研究［J］.东南国防医药，2005,7(3):166-168,180.
[9］林军祥,胡晓燕.联合用药治疗老年人消化性溃疡急性上消化道出血120例［J］.实用医学杂志，2010,26(12)：2218-2219.
[10］Kijsirichareanchai K,Ngamruengphong S,Rakvit A,et al.The utilization of standardized order sets using AASLD guidelines for patients with suspected cirrhosis and acute gastrointestinal bleeding［J］.Qual Manag Health Care,2013,22(2):146-151.
[11］孙 强,郑 正.奥曲肽治疗急性水肿型胰腺炎72例临床研究［J］.中华全科医学,2013,11(5):714-715.
[12］Li J,Wang R,Tang C.Somatostatin and octreotide on the treatment of acute pancreatitis-basic and clinical studies for three decades［J］.Curr Pharm Des，2011,17(16):1594-1601.
[13］赵铁军,汪 雷,杨立信,等.奥曲肽在治疗食管癌术后胸腔渗液中的应用［J］.中华消化杂志,2010,30(12):908-909.
[14］Paramés F,Freitas I,Fragata J,et al.Octreotide--additional conservative therapy for postoperative chylothorax in congenital heart disease［J］.Rev Port Cardiol，2009,28(7-8):799-807.
[15］Sharkey AJ,Rao JN.The successful use of octreotide in the treatment of traumatic chylothorax［J］.Tex Heart Inst J,2012,39(3):428-430.
[16］Zárate Moreno FA,Oms Bernad LM,Mato Ruiz R,et al.Efficacy of octreotide in the treatment of chyle fistulas associated with pancreatic disease［J］.Cir Esp,2013,91(4):237-242.
[17］顾恺时.胸心外科手术学［M］.上海：上海科学技术出版社，2003：609.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2013-09-20