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[1]王超君,谷 娜,孙义峰,等.创面用复方喷雾膜剂的制备及其性质研究[J].医学研究与战创伤救治(原医学研究生学报),2013,15(06):577-580.[doi:10.3969/j.issn.1672-271X.2013.06.008]
　WANG Chao-jun,GU Na,SUN Yi-feng,et al.Preparation and valuation of compound spraying film for wound[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2013,15(06):577-580.[doi:10.3969/j.issn.1672-271X.2013.06.008]
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创面用复方喷雾膜剂的制备及其性质研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第15卷
期数:
2013年06期
页码:
577-580
栏目:
出版日期:
2013-11-20

文章信息/Info

Title:
Preparation and valuation of compound spraying film for wound
作者:
王超君1; 谷 娜1; 孙义峰1; 朱羞阳2; 陈 博1
1.310007 浙江杭州 南京军区杭州疗养院；2.310013 浙江杭州，空军杭州航空医学鉴定训练中心
Author(s):
WANG Chao-jun1; GU Na1; SUN Yi-feng1; ZHU Xiu-yang2; CHEN Bo1.
1.Hangzhou Sanatorium of Nanjing Military Region，Hangzhou,Zhejiang 310007，China；2.Air force Hangzhou Aviation Medicine Assessment and Training Center，Hangzhou，Zhejiang 310013，China
关键词:
复方喷雾膜剂; 创面治疗; 制备和评价
Keywords:
compound spraying film;  wound healing;  preparation and evaluation
分类号:
R917;TQ463
DOI:
10.3969/j.issn.1672-271X.2013.06.008
文献标志码:
A
摘要:
目的 研制创面用复方喷雾膜剂(compound spraying film,CSF)，并进行质量评价。方法 采用物理混合法制备CSF，评价其成膜性能和机械性能；以HPLC法测定其含量和释药行为；建立大鼠创面模型，评价其创面愈合效果。结果 CSF的成膜温度为(30±2)℃，成膜时间为(29±6)s，机械性质良好。CSF含人参皂苷(GRg1) (5.82±0.08)mg/g，体外释药以骨架溶蚀为主，释药动力学符合零级方程和Ritger-Peppas方程特征。CSF用于治疗大鼠背部机械创伤，愈合百分率均显著高于复方水溶液组和空白喷雾膜剂组(P＜0.05)。结论 CSF使用方便，性质优良，促愈效果明显，具有良好的应用前景。
Abstract:
Objective To prepare and evaluate a novel compound spraying film(CSF) for wound.Methods CSF was prepared by physical mixing method,and filming ability and mechanical character were evaluated.The content and drug release behavior of CSF were determined by HPLC method.Rat wound model was established to evaluate the therapeutic effect.Results Its temperature of filming was (30±2)℃,time of filming was (29±6)s and its mechanical character was fine.The content of Rgl was (5.82±0.08)mg/g.The drug release mechanism was erosion,and the drug release kinetics fitted zero order and Ritger-Peppas equations.The healing percentage in CSF group was higher than control groups(P<0.05).Conclusion CSF was user-friendly and effective for wound healing.It has a good application prospect.

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备注/Memo

备注/Memo:
南京军区杭州疗养院院管课题(2011B03)
更新日期/Last Update: 2013-11-20