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[1]丁 妍,崔 莉,花曼曼,等.当归多糖与黄芪多糖配伍对辐射损伤模型小鼠的保护作用[J].医学研究与战创伤救治(原医学研究生学报),2014,16(06):572-574.[doi:10.3969/j.issn.1672-271X.2014.06.004]
　DING Yan,CUI Li,HUA Man-man,et al.Protective effect of angelica sinensis polysaccharide and astragalus polysaccharides on radiation injury in mice model of compatibility[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(06):572-574.[doi:10.3969/j.issn.1672-271X.2014.06.004]
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当归多糖与黄芪多糖配伍对辐射损伤模型小鼠的保护作用()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第16卷
期数:
2014年06期
页码:
572-574
栏目:
出版日期:
2014-11-20

文章信息/Info

Title:
Protective effect of angelica sinensis polysaccharide and astragalus polysaccharides on radiation injury in mice model of compatibility
作者:
丁 妍1; 崔 莉2; 花曼曼1; 张勇妹1; 郭贵宾1; 孙 锐1; 陈邦元1
1.212001 江苏镇江,解放军359医院药械科；2.210028 江苏南京，江苏省中医药研究院
Author(s):
DING Yan1; CUI Li2; HUA Man-man1; ZHANG Yong-mei1; GUO Gui-bin1; SUN Rui1; CHEN Bang-yuan1.
1.Pharmacy Department,359 Hospital of PLA,Zhenjiang,Jiangsu 212001,China;2.Jiangsu Provincial Academy of Traditional Chinese Medicine,Nanjing,Jiangsu 210028,China
关键词:
当归多糖; 黄芪多糖; 配伍; 辐射保护作用
Keywords:
angelica polysaccharides;  astragali radix polysaccharides;  compatibility;  radioprotective effect
分类号:
R285.5
DOI:
10.3969/j.issn.1672-271X.2014.06.004
文献标志码:
A
摘要:
目的 研究当归多糖与黄芪多糖配伍对辐射损伤模型小鼠的保护作用。方法 采用60Co γ射线对小鼠进行全身照射复制辐射损伤模型。以小鼠30 d 存活率和死亡小鼠平均 存活时间、小鼠外周血白细胞数、骨髓细胞DNA 含量、血清丙二醛(MDA)含量为指标，观察当归多糖、黄芪多糖及其不同比例配伍对辐射损伤模型小鼠的保护作用。结果 在当归多 糖、黄芪多糖及其不同比例配伍的药物保护组中，小鼠30 d平均存活率升高，死亡小鼠平均存活时间延长，外周白细胞计数增加，骨髓细胞DNA含量增加，MDA含量降低。结论 当归 多糖、黄芪多糖及其不同比例配伍对辐射损伤模型小鼠均有一定的保护作用，其中以当归多糖∶黄芪多糖(3∶1)配伍的效果最佳。
Abstract:
Objective To study the protective effects of Angelica polysaccharides and Astragali Radix polysaccharides on radiation model mice.Methods The mice were total body irradiation to copy the radiation injury model by 60Co γ ray.In 30 d mice survival rate and mean survival time of mice death in mice,the number of WBC in peripheral blood,bone marrow cells,the content of DNA of serum malondialdehyde (MDA) content as the index; to observe the protective effect of Angelica polysaccharide,astragalus polysaccharide and different proportions of radiation injury mice model.Results Drug protection group of Angelica polysaccharide,astragalus polysaccharide and different proportion of mice 30 d,average survival rate increased,the death of mice prolonged the mean survival time,peripheral white blood cell count increased,increasing the content of DNA in bone marrow cells,decreasing the content of MDA.Conclusion Polysaccharide of Chinese angelica,astragalus polysaccharides and its different proportions of injury mouse model of radiation has a certain,with Angelica polysaccharide,astragalus polysaccharide (3∶1) on the compatibility of the best effect.

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备注/Memo

备注/Memo:
南京军区医学科技创新课题(12MA042)
更新日期/Last Update: 2014-11-20