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[1]徐 锋,位志峰,徐晓峰,等.萘哌地尔片联合复方利多卡因乳膏治疗慢性非细菌性前列腺炎合并早泄的疗效观察[J].医学研究与战创伤救治(原医学研究生学报),2015,17(04):358-361.[doi:10.3969/j.issn.1672-271X.2015.04.007]
　XU Feng,WEI Zhi-feng,XU Xiao-feng,et al.Effectiveness of Naftopitil and compound lidocaine cream for chronic nonbacterial prostatitis complicated with premature ejaculation[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(04):358-361.[doi:10.3969/j.issn.1672-271X.2015.04.007]
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萘哌地尔片联合复方利多卡因乳膏治疗慢性非细菌性前列腺炎合并早泄的疗效观察()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第17卷
期数:
2015年04期
页码:
358-361
栏目:
出版日期:
2015-07-20

文章信息/Info

Title:
Effectiveness of Naftopitil and compound lidocaine cream for chronic nonbacterial prostatitis complicated with premature ejaculation
作者:
徐 锋1; 位志峰1; 徐晓峰1; 程 文1; 葛京平1; 张征宇1; 郑大东2
210002 江苏南京，南京军区南京总医院，1.泌尿外科，2.干部保健科
Author(s):
XU Feng1;  WEI Zhi-feng1;  XU Xiao-feng1;  CHENG Wen1;  GE Jing-ping1;  ZHANG Zheng-yu1;  ZHENG Da-dong2.
1.Department of Urology， 2.Department of Ranking Health Protection， Nanjing General Hospital of Nanjing Military Command， Nanjing， Jiangsu 210002， China
关键词:
慢性非细菌性前列腺炎; 早泄; 萘哌地尔片; 复方利多卡因乳膏
Keywords:
chronic nonbacterial prostatitis;  premature ejaculation;  naftopitil;  compound lidocaine cream
分类号:
R698
DOI:
10.3969/j.issn.1672-271X.2015.04.007
文献标志码:
A
摘要:
目的 观察a1肾上腺素能受体阻滞剂萘哌地尔片联合复方利多卡因乳膏治疗慢性非细菌性前列腺炎合并早泄的临床疗效。方法 120例早泄患者以萘哌地尔片(25 mg，每晚睡前服用1次)、局部涂抹复方利多卡因乳膏治疗，疗程8周。治疗前后用前列腺液常规、前列腺炎症状评分、尿流动力学检查、患者平均阴道内射精潜伏期、性生活满意度、每周性交频率等为评估指标观察疗效。结果 治疗8周后，美国国立卫生研究院慢性前列腺炎症状指数(National Institute of Health Chronic Prostatitis Symptom Index，NIH-CPSI)评分较治疗前分别平均降低12.5，症状尺度评分平均降低8.3，疼痛与不适评分平均降低6.7，排尿症状评分平均降低3.0，生活质量评分平均降低4.1，白细胞计数平均降低15.8个/高倍视野(high power field，HP)；治疗前后最大尿道闭合压(MUCP)、最大尿道压(MUP)和残余尿量(RU)明显降低(P<0.05)，分别为(687.4±133.5)Pa与(508.6±109.5)Pa、(909.4±140.2)Pa与(702.5±123.8)Pa、(51.0±14.0)mL与(8.0±5.0)mL;平均尿流率(Qave)和最大尿流率(Qmax)明显提高(P<0.05)，分别为(8.2±3.8)mL/s与(11.8±2.9)mL/s、(15.4±5.9) mL/s与(20.8±4.8)mL/s；患者射精潜伏期、患者性交满意度、配偶性交满意度、每周性交频率分别由(0.56±0.35) min、(6.2±1.0)次/周、(4.9±1.0)次/周、(1.0±0.4)次/周提高到(3.79±1.61) min、(10.0±1.7)次/周、(9.1±1.2)次/周、(2.6±0.4)次/周。治疗过程中不良事件发生率1.67%。结论 萘哌地尔片联合复方利多卡因乳膏治疗慢性非细菌性前列腺炎合并早泄，疗效满意，临床上值得推广使用。
Abstract:
Objective To observe the effectiveness of the α1 blocker naftopidil and compound lidocaine cream in the treatment of chronic nonbacterial prostatitis(CNP) with premature ejaculation(PE). Methods 120 cases of patients who had been diagnosed as CNP complicated with PE were treated with naftopidil (once 25 mg, once a day before sleeping) and compound lidocaine cream for 8 weeks. The effectiveness of the drug were observed by comparing Prostatic secretion examination (EPS), chronic prostatitis symptomindex (CPSI), Urodynamics, Intravaginal ejaculatory latency time(IELT), the intercourse satisfaction and the mean of coituses per week obtained before and after the treatment. Results After 8 weeks medication, total score of NIH-CPSI, symptom score, pain score, voiding symptoms, the quality of life, white cell count in all patients before and after treatment by an average of 12.5 points, 8.3 points, 6.7 points, 3.0 points, 4.1 points, 15.8/HP.The MUCP (687.4±133.5 vs 508.6±109.5), MUP (909.4±140.2 vs 702.5±123.8), RU (51.0±14.0 vs 8.0±5.0), Qave (8.2±3.8 vs 11.8±2.9) and Qmax (15.4±5.9 vs 20.8±4.8) were significant different (P<0.05). The outcome of the mean IELT, the sexual intercourse satisfaction (SIS), the patients partners sexual activity satisfaction(partners SIS), the mean number of coituses per week (NC/w) in all patients increased from 0.56±0.35, 6.2±1.0, 4.9±1.0, 1.0±0.4 to 3.79±1.61, 10.0±1.7, 9.1±1.2, 2.6±0.4. Only 1 patient (1.67%) experienced the adverse event of dizziness. Conclusion Naftopidil and compound lidocaine cream are both effective and safe in the treatment of CNP complicated with PE which indicated that it is worthy of application widely.

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备注/Memo

备注/Memo:
南京军区南京总医院院管课题(2015011)
更新日期/Last Update: 2015-07-20