|本期目录/Table of Contents|

[1]夏桂枝,任榕娜,杨勇辉,等.婴幼儿难治性癫痫的手术治疗效果分析[J].医学研究与战创伤救治(原医学研究生学报),2015,17(04):378-379，411.[doi:10.3969/j.issn.1672-271X.2015.04.013]
　XIA Gui-zhi,REN Rong-na,YANG Yong-hui,et al.Surgical outcomes of infants with intractable epilepsy[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(04):378-379，411.[doi:10.3969/j.issn.1672-271X.2015.04.013]
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婴幼儿难治性癫痫的手术治疗效果分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第17卷
期数:
2015年04期
页码:
378-379，411
栏目:
出版日期:
2015-07-20

文章信息/Info

Title:
Surgical outcomes of infants with intractable epilepsy
作者:
夏桂枝1; 任榕娜1; 杨勇辉1; 梅 珍2; 杨朋范2
350025 福建福州，南京军区福州总医院(福建医科大学福总临床医学院)，1.儿科，2.神经外科癫痫中心
Author(s):
XIA Gui-zhi1;  REN Rong-na1;  YANG Yong-hui1;  MEI Zhen2;  YANG Peng-fan2.
1.Department of Pediatrics， 2.Epilepsy Center， Department of Neurosurgely， Fuzhou General Hospital of Nanjing Military Command (Clinical Medical College of Fuzhou General Hospital， Fujian Medical University)， Fuzhou， Fujian 350025， China
关键词:
婴幼儿; 难治性癫痫; 手术
Keywords:
infant;  intractable epilepsy;  surgery
分类号:
R742.1
DOI:
10.3969/j.issn.1672-271X.2015.04.013
文献标志码:
A
摘要:
目的 探讨婴幼儿难治性癫痫的手术治疗效果、安全性及致痫灶病理类型。方法 2010年1月-2014年6月某院神经外科癫痫中心进行手术治疗并随访至少6个月的11例9个月～2岁10个月婴幼儿难治性癫痫病例，采用Engel分级分析术后癫痫控制情况，观察术后并发症发生情况，并分析手术切除的致痫灶的病理类型。结果 术后Engel分级:8例Ⅰ级，1例Ⅱ级，2例Ⅲ级；所有病例术后均未见严重并发症发生；病理类型及相对应手术治疗效果:节细胞胶质瘤1例，海绵状血管瘤1例，胚胎发育不良性神经上皮性肿瘤1例，海马硬化2例，手术治疗效果均达到EngelⅠ级；局灶性皮质发育不良4例，手术效果2例达到EngelⅠ级，1例EngelⅡ级，1例Engel Ⅲ级；2例行胼胝体切开术，手术效果1例达到EngelⅠ级，1例达到Engel Ⅲ级。结论 在充分的术前评估的基础上，对婴幼儿难治性癫痫进行手术治疗具有较好的治疗效果和安全性，致痫灶病理类型与手术治疗效果密切相关。
Abstract:
Objective To explore the efficacy and safety of surgery for infants with intractable epilepsy, analyze the pathological features of epileptogenic foci. Methods The outcomes of 11 intractable epilepsy patients (aged 9-34 month) that underwent surgery were collected between January 2010 to June 2014. All patients were followed up for at least 6 months after surgery. The efficacy of surgery was evaluated with Engel class, the complications of surgery and pathological features of epileptogenic foci were observed after surgery. Results Postoperative Engel classes were Ⅰ, Ⅱ, and Ⅲ in 8 patients, 1 patient, and 2 patients, respectively. No patient suffered from severe complications. The major pathological findings in these patients included: ganglioglioma in 1 case, cavernous angioma in 1 case, dysembryoplastic neuroepithelial tumor in 1 case, hippocampal sclerosis in 2 case, these 5 patients achieved Engel class Ⅰoutcomes. Focal cortical dysplasia in 4 cases, 2 patients achieved Engel classⅠoutcomes, 1 patient achieved Engel Ⅱoutcome, 1 patient achieved Engel class Ⅲ outcome. Corpus callosotomy was conducted in 2 patients, 1 patient achieved Engel classⅠoutcome, 1 patient achieved Engel class Ⅲ outcome. Conclusion Surgery for infant with intractable epilepsy was effective and safe basing on the sufficient evaluation before surgery. There was a close contact between the efficacy of surgery and pathological type.

参考文献/References:

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2015-07-20