[1]王 闰,孟 慧,许 勇.复方甘草软膏的制备及含量测定法的建立[J].医学研究与战创伤救治(原医学研究生学报),2015,17(04):389-392.[doi:10.3969/j.issn.1672-271X.2015.04.017]
WANG Run,MENG Hui,XU Yong..To prepare the compound liquorice ointment and establish the determination method of the compound liquorice ointment[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(04):389-392.[doi:10.3969/j.issn.1672-271X.2015.04.017]
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复方甘草软膏的制备及含量测定法的建立(
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WANG Run,MENG Hui,XU Yong..To prepare the compound liquorice ointment and establish the determination method of the compound liquorice ointment[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(04):389-392.[doi:10.3969/j.issn.1672-271X.2015.04.017]
)《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]
- 卷:
- 第17卷
- 期数:
- 2015年04期
- 页码:
- 389-392
- 栏目:
- 出版日期:
- 2015-07-20
文章信息/Info
- Title:
- To prepare the compound liquorice ointment and establish the determination method of the compound liquorice ointment
- Keywords:
- licorice; doxepin hydrochloride; ointment; thin layer chromatography; UV; high performance liquid chromatography; quality standard
- 分类号:
- R927.2
- 文献标志码:
- A
- 摘要:
- 目的 以甘草提取物和盐酸多塞平为主药制备复方甘草软膏，并建立质量标准。方法 使用O/W法制备软膏，采用薄层色谱法(TLC)鉴别甘草、采用紫外扫描法(UV)鉴别盐酸多塞平；采用高效液相色谱法(HPLC)测定软膏中甘草酸和盐酸多塞平的含量。结果 通过比移值(Rf值)的比较可鉴定软膏中的甘草提取物；通过紫外扫描的吸收峰来鉴别软膏中的多塞平。采取不同的色谱条件在波长252 nm及290 nm处分别测定软膏中的甘草酸和多塞平的含量。测定三个批次的复方甘草软膏，每克软膏中甘草酸的含量均大于16.2 mg，多塞平的含量均在45～55 mg。结论 复方甘草软膏中的主药甘草及盐酸多塞平可以通过薄层色谱和紫外鉴定，采用高效液相色谱可以测定软膏中主药的含量。
- Abstract:
- Objective To prepare the compound liquorice ointment with the extract of liquorice and doxepin hydrochloride, and to establish the quality standard of this ointment. Methods The extract of liquorice was identified by TLC, and doxepin hydrochloride was identified by UV. The content of glycyrrhizic acid and doxepin hydrochloride of the ointment was determined by HPLC. Results The extract of liquorice could be identified through the comparison of the Rf value. Doxepin hydrochloride could be identified through the absorption peak of UV. The content of glycyrrhizic acid and doxepin hydrochloride of the ointment was determined by HPLC with the different chromatographic condition at 252 nm and 290 nm. To determine the three batches of the ointment, the content of glycyrrhizic acid was above 16.2 mg in each gram ointment, and doxepin hydrochloride was between 45-55 mg. Conclusion The extract of liquorice and doxepin hydrochloride could be identified by TLC and UV. The principal agent content of ointment could be determined by HPLC.
参考文献/References:
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