|本期目录/Table of Contents|

[1]周向毅,丁妍,陈邦元,等.复方康复灵对体部伽玛刀治疗非小细胞肺癌引起的急性放射反应的防护作用[J].医学研究与战创伤救治(原医学研究生学报),2015,17(05):455-457.[doi:10.3969/j.issn.1672-271X.2015.05.002]
　ZHOU Xiang-yi,DING Yan,CHEN Bang-yuan,et al.Protective effect of compound Kangfuling on body gamma knife in treating acute radiation reaction of non-small cell lung cancer[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(05):455-457.[doi:10.3969/j.issn.1672-271X.2015.05.002]
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复方康复灵对体部伽玛刀治疗非小细胞肺癌引起的急性放射反应的防护作用()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第17卷
期数:
2015年05期
页码:
455-457
栏目:
出版日期:
2015-09-30

文章信息/Info

Title:
Protective effect of compound Kangfuling on body gamma knife in treating acute radiation reaction of non-small cell lung cancer
作者:
周向毅1; 丁妍2; 陈邦元2; 张勇妹2; 孙锐2; 尹志强3
212001 江苏镇江，解放军359医院，1.肿瘤科，2.药械科，3.院部
Author(s):
ZHOU Xiang-yi1;  DING Yan2;  CHEN Bang-yuan2;  ZHANG Yong-mei2;  SUN Rui2;  YIN Zhi-qiang3.
1.Department of Oncology， 2.Department of Pharmacy， 3.Office of the Hospital， 359 Hospital of PLA， Zhenjiang， Jiangsu 212001， China
关键词:
非小细胞肺癌;  体部伽玛刀;  急性放射反应：复方康复灵
Keywords:
the non-small cell lung cancer;  body gamma knife;  acute radiation reaction;  the compound Kangfulin
分类号:
R734.2
DOI:
10.3969/j.issn.1672-271X.2015.05.002
文献标志码:
A
摘要:
目的 探讨复方康复灵对体部伽玛刀治疗非小细胞肺癌急性放射反应的防护作用。方法选取接受体部伽玛刀治疗的非小细胞肺癌患者107例，随机分为观察组（55例）和对照组（52例）。观察组在放疗开始后给予复方康复灵口服，疗程1个月，比较两组的急性放射反应。结果治疗后观察组患者外周血白细胞下降发生率为5.5%，对照组为21.2%（P<0.05）；观察组急性放射性肺炎发生率为16.4%，对照组为15.4%（P>0.05）；观察组急性放射性食管炎发生率为25.5%，对照组为28.8%（P>0.05）。结论复方康复灵对非小细胞肺癌患者接受体部伽玛刀治疗引起的外周血白细胞下降具有较好的预防作用，值得临床推广。
Abstract:
Objective To investigate the protective effect of compound Kangfulin on acute radiation reaction of the body gamma knife in treatment of non-small cell lung cancer. Methods To select 107 patients who received the body gamma knife treatment of non-small cell lung cancer， then divided them into observation group (55 cases)and control group (52 cases) randomly. The observation group was given the compound Kangfulin for a month after the beginning of radiotherapy， and compared the acute radio injury between two groups. Results The decreasing incidence of peripheral blood leukocytes in observation group was 5.5% and control group was 21.2%. The difference was statistically significant (P<0.05). The incidence of acute radiation pneumonitis in observation group was 16.4% and control group was 15.4%. The difference was not statistically significant (P>0.05). The incidence of acute radiation esophagitis in observation group was 25.5% and control group was 28.8%. The difference was not statistically significant (P>0.05). Conclusion The compound kangfulin has a good preventive effect on the decreasing Peripheral blood leukocytes of the non-small cell lung cancer patients who have received body gamma knife treatment. It was worthy of promotion in clinic.

参考文献/References:

[1]吴铁鹰，刘永兰，张峻青，等.体部伽玛刀治疗Ⅰ、Ⅱ期非小细胞肺癌疗效分析[J].中国临床实用医学，2014，5(2)：6-8.
[2]王碧云，杨佩浓，杨海华，等.芪胶升白胶囊治疗肺癌放疗期间白细胞抑制的效果观察[J].中国医药，2014，9(2)：176-178.
[3]周际昌.实用肿瘤内科学[M].2版.北京：人民卫生出版社，2003：47-48.
[4]殷蔚伯，谷铣之.肿瘤放射治疗学[M].3版.北京：中国协和医科大学出版社，2002：1108-1110.
[5]Li Rui，Chenwei-chang，Wang Wei-peng，et al.Antioxidant activity of astragalus polysaccharides and antitumouractivity of the polysaccharides and siRNA [J].Carbohydrate polymers，2010，82（2）：240-244.
[6]Williams JP，Brown SL，Georges GE，et al.Animal models for medical countermeasures to radiation exposure[J].Rad Res，2010，173(4)：557-558.
[7]Van Landeghem L，Blue ＲE，Dehmer JJ，et al.Localized intestinal radiation and liquid diet enhance survival and permit evaluation of long-term intestinal esponses to high dose radiation in mice [J].Plos One，2012，7(12)：e51310.
[8]Yongwen Zhang，Yamada.Complement activation galactan chains in a pectic arabinogalactan(AGⅡb-1) from the roots of Angelica acutiloba Kitagawa [J].Carbohydrate Polymer，1996，31：149-156.
[9]Lee SE，Yang TA.Radiation protective effects of two traditional Chinese medicine presriptions si-wu-tang and si-jun-zi-tang[J].Am J Chin Med，1999，27（3 ）：387-396.
[10]国家药典委员会.中华人民共和国药典：一部[S].2010 版.北京：中国医药科技出版社，2010：196.
[11]丁海玲，李华伟，李雪花，等.复方黄芪多糖对小鼠的抗疲劳和耐缺氧作用[J].延边大学医学学报，2009，32(4)：160-162.
[12]钟 灵，王振富，文德鉴，等.黄芪多糖抗衰老作用的实验研究[J].中国应用生理学杂志，2013，29(4)：350-352.
[13]晏洪波，梁 文.黄芪的免疫调节及抗病毒作用[J].华南国防医学杂志，2008，22(6)：69-70.
[14]王君巧，聂少平，余 强，等.灵芝多糖对免疫抑制小鼠的免疫调节和抗氧化作用[J].食品科学，2012，33(23)：274-277.
[15]王 宁，李应东，刘 凯.当归、黄芪及其有效成分抗辐射作用研究概况[J].中国辐射卫生，2008，17(1)：121-122.
[16]张 燕，王晓萍.中药防治放射性口腔干燥症用药规律的探讨[J].东南国防医药，2012，14(1)：39-41.
[17]杨新辉，苏加利，周光华，等.体部伽玛刀疗非小细胞肺癌的效果及其影响因素[J].医学临床研究，2008，25(2)：236-239.
[18]江晓肖，宋水川，陈达伟.伽玛刀治疗对胰腺癌患者外周T淋巴细胞亚群的影响[J].东南国防医药，2012，14(2)：129-131.

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备注/Memo

备注/Memo:
南京军区医学科技创新课题（12MA042）
更新日期/Last Update: 2015-09-20