|本期目录/Table of Contents|

[1]叶德邵,徐霞,张兰玲,等.痛风性关节炎发病的危险因素[J].医学研究与战创伤救治(原医学研究生学报),2015,17(05):461-463.[doi:10.3969/j.issn.1672-271X.2015.05.004]
　YE De-shao,XU Xia,ZHANG Lan-ling,et al.Case-control study of risk factors for acute attack of gout[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(05):461-463.[doi:10.3969/j.issn.1672-271X.2015.05.004]
点击复制

痛风性关节炎发病的危险因素()
分享到62.8K

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第17卷
期数:
2015年05期
页码:
461-463
栏目:
出版日期:
2015-09-30

文章信息/Info

Title:
Case-control study of risk factors for acute attack of gout
作者:
叶德邵1; 徐霞2; 张兰玲2; 施冶青2; 高洁2; 赵东宝2
1.362000 福建泉州，解放军180医院风湿免疫科；2.200433 上海，第二军医大学附属长海医院风湿免疫科
Author(s):
YE De-shao1;  XU Xia2;  ZHANG Lan-ling2;  SHI Ye-qing2;  GAO Jie2;  ZHAO Dong-bao2.
1.Rheumatology and Immunology Department， 180 Hospital of PLA， Quanzhou， Fujian 362000， China； 2.Rheumatology and Immunology Department of Changhai Hospital of Second Military Medical University， Shanghai 200433， China
关键词:
痛风; 危险因素; 病例对照研究; Logistic回归模型
Keywords:
gout;  risk factors;  case-control study;  logistic regression model
分类号:
R589.7
DOI:
10.3969/j.issn.1672-271X.2015.05.004
文献标志码:
A
摘要:
目的 探讨痛风性关节炎发病的危险因素、常见体检和生化检查项目对早期诊断痛风性关节炎发病的意义，为预防痛风发病提供依据。方法采用配对病例对照研究，以2014年6-12月间发生痛风并到上海某三甲医院门诊就诊的104例为痛风组，以未发过痛风且性别、年龄等匹配的104例体检者为对照组。收集身高、体重、血压等一般资料，并进行血生化检查，将检查结果进行多因素条件Logistic回归分析。结果痛风性关节炎患者首发年龄为（43.72±0.93）岁，95%可信区间为41.87~45.57。发病具有明显性别差异，男∶女为16.3∶1。高尿酸血症、高胆固醇血症、高三酰甘油血症、高舒张压为痛风发病的主要相关因素，优势比为29.321（P<0.001）、25.738（P=0.002）、10.179（P<0.001）、3.270（P=0.042）。结论痛风性关节炎常发生于40岁以上男性。高尿酸血症、高胆固醇血症、高三酰甘油血症、高舒张压4个因素为痛风发病的危险因素。
Abstract:
Objective To analyze the risk factors related to acute attack of gout and to provide advise to prevent the patient from the acute attack of the gout. Methods The research introduced a 1：1 matched case-control study. 104 patients with an attack of acute gout were included as the patient group and 104 healthy people with matched age and gender as the control group. The general data such as the height， the body mass， the blood pressure of the two groups were recorded and the blood biochemistry test of the two groups were taken. Multivariate logistic regression analysis was adopted to analyse the data. Results The average age of the patients with gout arthritis was （43.72±0.93） years old， and the 95% confidence interval was 41.87-45.57. The difference between the gender is obvious with ratio was 16.3∶1 (the male versus the female). Uric acid， total cholesterol， triglyceride and diastolic blood pressure were the four factors that influence the acute attack of gout. The relative risk was 29.321 (P<0.001)， 25.738 (P=0.002)， 10.179 (P<0.001) and 3.270 (P=0.042) respectively. Conclusion A man in his forties is easily attacked by gout. Hyperuricemia， high blood level of total cholesterol， triglyceride and diastolic blood pressure are the four risk factors for acute attack of gout.

参考文献/References:

[1]Chilappa CS，Aronow WS，Shapiro D，et al.Gout and hyperuricemia[J].Compr Ther，2010，36：3-13.
[2]中华医学会风湿病学分会.原发性痛风诊断和治疗指南[J].中华风湿病学杂志，2011，15（6）：410-413.
[3]赵东宝，万 伟，徐 霞.痛风诊断标准的演变及其影像学检查在临床中的应用[J].诊断学理论与实践，2014，13（3）：229-231.
[4]程晓雨，苗志敏，杨雯雯，等.山东沿海地区家族性痛风431例临床特点分析[J].中华风湿病学杂志，2012，16（4）：239-242.
[5]Reuss-Borst M.Update gout：what has changed in diagnosis and treatment[J].MMW Fortschr Med，2014，156(20)：58-62.
[6]lvarez-Lario B，Alonso-Valdivielso JL.Hyperuricemia and gout； the role of diet[J].Nutr Hosp，2014，29(4)：760-770.
[7]宋 薇，刘精东，陈志雄，等.南昌地区40岁以上社区居民高尿酸血症和痛风的患病率调查及相关影响因素分析[J].中国全科医学，2014，17（2）：181-184.
[8]Kim SC，Liu J，Solomon DH.Risk of incident diabetes in patients with gout：a cohort study[J].Arthritis Rheumatol，2015，67(1)：273-280.
[9]Krishnan E.Goutin African Americans[J].Am J Med，2014，127(9)：858-864.
[10]王颜刚，阎胜利，李长贵，等.原发性高尿酸血症患者发生痛风的前瞻性研究[J].中华内分泌代谢杂志，2011，27（7）：553-556.
[11]Roddy E，Choi HK.Epidemiology of gout[J].Rheum Dis Clin North Am，2014，40(2)：155-175.
[12]Bruderer S，Bodmer M，Jick SS，et al.Use of diuretics and risk of incident gout：a population-based case-control study[J].Arthritis Rheumatol，2014，66 (1)：185-196.
[13]Dubreuil M，Neogi T，Chen CA，et al.Increased risk of recurrent gout attacks with hospitalization[J].Am J Med，2013，126(12)：1138-1141.
[14]Manara M，Bortoluzzi A，Favero M，et al.Italian Society of rheumatology recommendations for the management of gout[J].Rheumatismo，2013，65(1)：4-21.
[15]Mandel EI，Taylor EN，Curhan GC.Dietary and lifestyle factors and medical conditions associated with urinary citrate excretion[J].Clin J Am Soc Nephrol， 2013，8(6)：901-908.
[16]Li C，Hsieh MC，Chang SJ.Metabolic syndrome，diabetes，and hyperuricemia[J].Curr Opin Rheumatol，2013，25(2)：210-216.

相似文献/References:

[1]张建忠,龙连圣,辛志成,等.中重型颅脑损伤并发脑梗死的危险因素分析[J].医学研究与战创伤救治(原医学研究生学报),2013,15(03):234.[doi:10.3969/j.issn.1672-271X.2013.03.009]
　ZHANG Jian-zhong,LONG Lian-sheng,XIN Zhi-cheng,et al.Risk factors for posttraumatic cerebral infarction in patients with moderate and severe head trauma[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2013,15(05):234.[doi:10.3969/j.issn.1672-271X.2013.03.009]
[2]王承峰,董文涛,任榕娜.影响局灶性发作癫痫患儿智力状况的危险因素分析[J].医学研究与战创伤救治(原医学研究生学报),2012,14(03):222.
　WANG Cheng-feng,DONG Wen-tao,REN Rong-na..Risk factors for intelligence quotient of children with focal seizures[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(05):222.
[3]阳文新,何咸兵,王跃华,等.肝移植术后弥漫性脑病的特点及危险因素分析[J].医学研究与战创伤救治(原医学研究生学报),2012,14(05):396.
　YANG Wen-xin,HE Xian-bing,WANG Yue-hua,et al.Features of diffuse encephalopathy after liver transplantation and its risk factors[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(05):396.
[4]曾素琴,陈小芳,吴金飞,等.出血性脑梗死相关危险因素及预后分析[J].医学研究与战创伤救治(原医学研究生学报),2012,14(05):422.
　ZENG Su-qin,CHEN Xiao-fang,WU Jin-fei,et al.Analysis of related risk factors and prognosis to cerebral hemorrhagic infarction[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(05):422.
[5]王学文综述.癌肿和静脉血栓栓塞相关性研究进展[J].医学研究与战创伤救治(原医学研究生学报),2010,12(02):128.
[6]陈 宏,刘永平,马建芳,等.歼击机飞行员腰腿痛的调查分析[J].医学研究与战创伤救治(原医学研究生学报),2009,11(06):508.
　CHEN Hong,LIU Yong-ping,MA Jian-fang,et al.Analysis of backleg pain in fighter pilots[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2009,11(05):508.
[7]许建华,陈贵敏.口腔门诊危险因素与控制[J].医学研究与战创伤救治(原医学研究生学报),2008,10(03):209.
[8]李晓萍,陈建波,邓 晗.飞行员代谢综合征患病率调查及危险因素分析[J].医学研究与战创伤救治(原医学研究生学报),2014,16(01):55.
　LI Xiao-ping,CHEN Jian-bo,DENG Han..A survey of prevalence of metabolic syndrome and its risk factors in pilots[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(05):55.
[9]魏 红,包维为,李 斌,等.老年人致跌的相关环境危险因素分析[J].医学研究与战创伤救治(原医学研究生学报),2014,16(02):168.[doi:10.3969/j.issn.1672-271X.2014.02.018]
　WEI Hong,BAO Wei-wei,LI Bin,et al.Analysis of the enviromentally relevanted risk factors on old men[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(05):168.[doi:10.3969/j.issn.1672-271X.2014.02.018]
[10]吴金飞,陈传琳,曾素琴,等.脑梗死危险因素及生化特征分析[J].医学研究与战创伤救治(原医学研究生学报),2014,16(03):270.[doi:10.3969/j.issn.1672-271X.2014.03.014]
　WU Jin-fei,CHEN Chuan-lin,ZENG Su-qin,et al.Risk factors and biochemical indicators of cerebral infarction[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(05):270.[doi:10.3969/j.issn.1672-271X.2014.03.014]

备注/Memo

备注/Memo:
上海市卫生系统优秀学科带头人新百人计划基金（XBR2011006）
更新日期/Last Update: 2015-09-20