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[1]丁 虹,唐雯静,庞燕芬,等.马齿苋多糖对宫颈癌细胞恶性生物学行为抑制作用的实验研究[J].医学研究与战创伤救治(原医学研究生学报),2016,18(01):38-40,58.[doi:10.3969/j.issn.1672-271X.2016.01.011]
　DING Hong,TANG Wen-jing,PANG Yan-fen,et al.Animal study on the inhibition effect of Portulaca oleracea polysaccharide on malignant behavior of cervical cancer cells[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2016,18(01):38-40,58.[doi:10.3969/j.issn.1672-271X.2016.01.011]
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马齿苋多糖对宫颈癌细胞恶性生物学行为抑制作用的实验研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第18卷
期数:
2016年01期
页码:
38-40,58
栏目:
出版日期:
2016-01-20

文章信息/Info

Title:
Animal study on the inhibition effect of Portulaca oleracea polysaccharide on malignant behavior of cervical cancer cells
作者:
丁 虹1; 唐雯静1; 庞燕芬1; 吕 雯2
1. 310002 浙江杭州，南京军区杭州疗养院海勤疗养区妇科；
2. 310013 浙江杭州，浙江省立同德医院妇产科
Author(s):
DING Hong1;  TANG Wen-jing1;  PANG Yan-fen1;  LU Wen2.
1. Department of Gynecology, Naval Logistics Branch of Hangzhou Sanatorium, Nanjing Militray Command, Hangzhou, Zhejiang 310002, China;
2. Department of Gynaecology and Obstetrics， Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310013, China
关键词:
宫颈癌; 马齿苋多糖; 凋亡; 血管新生; 三磷酸腺苷
Keywords:
cervical cancer;  portulacaoleracea polysaccharide;  apoptosis;  angiogenesis;  ATP
分类号:
R737.33;R285.5
DOI:
10.3969/j.issn.1672-271X.2016.01.011
文献标志码:
A
摘要:
目的 研究马齿苋多糖对宫颈癌细胞恶性生物学行为的抑制作用。方法 选择c57小鼠并建立宫颈癌荷瘤鼠模型，随机分为对照组、低剂量组、中剂量组和高剂量组 4组，分别接受等渗盐水、100、200、400 mg/kg马齿苋多糖腹腔注射。治疗后检测移植瘤的体积、重量以及移植瘤中细胞凋亡数目、ATP含量、新生血管分子的表达量。结果 低剂 量组、中剂量组和高剂量组的瘤体体积和重量、移植瘤组织中的ATP含量以及血管内皮生长因子(VEGF)、CD13、CD34的表达量均低于对照组，凋亡细胞数目多于对照组。马齿苋多糖 能够以剂量依赖性的方式降低移植瘤的体积、重量以及移植瘤中细胞凋亡数目、ATP含量、新生血管血管分子的表达量，增加凋亡细胞的数目。结论 马齿苋多糖能够抑制宫颈癌移 植瘤的生长、诱导癌细胞凋亡、干扰氧化供能、减少新生血管数目，对宫颈癌细胞恶性生物学行为具有抑制作用。
Abstract:
Objective To study the inhibition effect of portulacaoleracea polysaccharide on malignant behavior of cervical cancer cells. Methods c57 mice were selected and cervical cancer bearing mice model were established and randomly divided into control group, low dose group, middle dose group and high dose group, which received saline, 100 mg/kg polysaccharide, 200 mg/kg polysaccharide, 400 mg/kg polysaccharide injection respectively. After treatment, tumor volume, weight and apoptosis cell number, ATP content, neovascularization vascular molecules in tumor were detected. Results Tumor volume, weight, ATP content and VEGF, CD13, CD34 expression level in tumor of low dose group, middle dose group and high dose group were lower than control group; portulacaoleracea polysaccharide reduced tumor volume, weight, ATP content and VEGF, CD13, CD34 expression level in tumor by a dose-dependent manner. Conclusion Portulacaoleracea polysaccharide can inhibit cancer tumor growth, increase cell apoptosis number, induce apoptosis, interfere oxidation energy, reduce new blood vessels number and inhibit malignant behavior of cervical cancer cells.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2016-01-20