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[1]蒋冠,杨春生,王纯,等.卡介菌多糖核酸联合光动力治疗尖锐湿疣临床效果及基因型检测[J].医学研究与战创伤救治(原医学研究生学报),2016,18(02):177-179.[doi:10.3969/j.issn.1672-271X.2016.02.021]
　JIANG Guan,YANG Chun-sheng,WANG Chun,et al.Efficacy of BCG-PSN combined with ALA-PDT in treatment of condyloma acuminatum and test of the genotyping of HPV[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2016,18(02):177-179.[doi:10.3969/j.issn.1672-271X.2016.02.021]
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卡介菌多糖核酸联合光动力治疗尖锐湿疣临床效果及基因型检测()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第18卷
期数:
2016年02期
页码:
177-179
栏目:
出版日期:
2016-04-09

文章信息/Info

Title:
Efficacy of BCG-PSN combined with ALA-PDT in treatment of condyloma acuminatum and test of the genotyping of HPV
作者:
蒋冠1; 杨春生2; 王纯2; 吴瑾2; 邢飞3; 葛海燕4
1. 221002 江苏徐州，徐州医学院附属医院皮肤性病科；2. 223002 江苏淮安，淮安市第二人民医院,皮肤性病科,3. 检验科,4. 感管科
Author(s):
JIANG Guan1;  YANG Chun-sheng2;  WANG Chun2;  WU Jin2;  XING Fei3;  GE Hai-yan4.
1. Department of Dermatology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, China; 2. Department of Dermatology, 3. Department of Laboratory, 4. Department of Infection Management, the Second Peoples Hospital of Huaian, Huaian,
关键词:
尖锐湿疣; 卡介菌多糖核酸; 光动力治疗
Keywords:
condyloma acuminatum;  Bacillus Calmette-Guerin-polysaccharile nucleic acid(BCG-PSN);  photodynamic therapy
分类号:
R752.53
DOI:
10.3969/j.issn.1672-271X.2016.02.021
文献标志码:
A
摘要:
目的 观察卡介菌多糖核酸联合5-氨基酮戊酸光动力（ALA-PDT）治疗尖锐湿疣临床效果及基因型检测。方法 采用单盲对照试验将76例尖锐湿疣患者随机分成试验组（41例）和对照组（35例），试验组采用卡介菌多糖核酸联合ALA-PDT治疗，对照组采用ALA-PDT治疗。全部患者每次治疗前均先用CO2激光祛除肉眼可见疣体。首次治疗时取部分疣体行人乳头瘤病毒（HPV）基因型检测。ALA-PDT治疗每周1次，共4次，卡介菌多糖核酸隔日1次肌注，持续8周。治疗结束后随访6个月，观察复发率。结果 试验组和对照组治愈率分别为95.1%、74.3%（P＜0.05），复发率分别为2.4%、20.0%（P＜0.05）。基因型检测结果：共检出71例15种，前三位依次为：HPV-6、HPV-16和HPV-11，未发现HPV 39、43、44、51、53和CP8304型，其中高危型47例、低危型26例、“高+低危型”混合交叉感染2例。单重感染60例，多重感染11例。结论 卡介菌多糖核酸联合ALA-PDT治疗尖锐湿疣临床效果明显，复发率低。基因型检测结果说明高危型感染率明显偏高，多重感染较少。
Abstract:
Objective To observe the efficacy of BCG-PSN combined with ALA-PDT in treatment of condyloma acuminatum and test the genotyping of HPV. Methods All patients with condyloma acuminatum were randomly divided into test group (n=41) and control group (n=35). The test group was treated with BCG-PSN combined with ALA-PDT, while the control group was treated with ALA-PDT only. The visible warts were burn up by CO2 laser before each treatment in all patients. Prior to the first session, HPV genotype of wart tissue was tested. The ALA-PDT was treated once a week and last for 4 weeks and the BCG-PSN was injected every two days and last for 8 weeks. Follow-up was scheduled on month 6 after the last treatment for the observation of recurrence rate. Results The cure rate of two groups was 95.1% and 74.3%(P<0.05) and the recurrence rate was 2.4% and 20.0%(P<0.05). All 71 cases had 15 kinds of HPV genotype, except HPV-39, 43, 44, 51, 53 and CP8304. The top three were HPV-6, HPV-16 and HPV-11 respectively. The high-risk, the low-risk and the high/lower-risk HPV genotypes were 47 cases, 26 cases and 2 cases respectively. The single and multiple infection were 60 cases and 11 cases respectively. Conclusion The efficacy of the test group is superior to the control group. High-risk HPV genotypes predominate in all patients and multiple infections is few.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2016-03-20