|本期目录/Table of Contents|

[1]龚光明,陈美惠,王曙东.人血浆蛋白多烯紫杉醇纳米粒子的自组装及对肿瘤的靶向性[J].医学研究与战创伤救治(原医学研究生学报),2016,18(05):468-471.[doi:10.3969/j.issn.1672-271X.2016.05.006]
　GONG Guang-ming,CHEN Mei-hui,WANG Shu-dong.Preparation and characterization of human serum albumin-docetaxel nanoparticles[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2016,18(05):468-471.[doi:10.3969/j.issn.1672-271X.2016.05.006]
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人血浆蛋白多烯紫杉醇纳米粒子的自组装及对肿瘤的靶向性()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第18卷
期数:
2016年05期
页码:
468-471
栏目:
出版日期:
2016-09-20

文章信息/Info

Title:
Preparation and characterization of human serum albumin-docetaxel nanoparticles
作者:
龚光明; 陈美惠; 王曙东
210002江苏南京，南京军区南京总医院制剂科
Author(s):
GONG Guang-ming;  CHEN Mei-hui;  WANG Shu-dong
Department of Pharmaceutics, Nanjing General Hospital of Nanjing Military Command, PLA， Nanjing, Jiangsu 210002, China
关键词:
血浆蛋白; 多烯紫杉醇; 纳米粒子; 自组装; 肿瘤靶向
Keywords:
human serum albumin;  docetaxel;  nanoparticles;  self-assembly;  tumor target
分类号:
R945
DOI:
10.3969/j.issn.1672-271X.2016.05.006
文献标志码:
A
摘要:
目的 提高多烯紫杉醇的溶解度，提高其靶向性能。方法 用二硫键断裂法制备人血清白蛋白多烯紫杉醇纳米粒子，并用电镜进行观察。对粒子载药量、稳定性及粒子对肿瘤部位趋向性进行表征。结果 二硫键断裂法成功组装了白蛋白-多烯紫杉醇纳米粒子。电镜观察该纳米粒子外貌为80～100 nm左右的球形粒子，高效液相和蛋白质定量检测多烯紫杉醇载药量可达21.5%。结果 白蛋白多烯紫杉醇纳米制剂可显著提高多烯紫杉醇的溶解度，提高对肿瘤靶向性。结论 白蛋白-多烯紫杉醇纳米粒子对肿瘤细胞具有良好的靶向作用，具有临床运用的潜在价值。
Abstract:
Objective To improve the solubility of docetaxel and reduce its toxic and side effects, and to improve the targeting capability of docetaxel. Methods The human serum albumin-docetaxel nanoparticles were prepared by the disulfide bond reduction method, and were observed by electron microscope. The drug loading efficiency, stability and targeting capability of nanoparticles were explored. Results Albumin-docetaxel nanoparticles were successfully fabricated through disulfide bond reduction. Albumin-docetaxel nanoparticles were about 80-100 nm in diameter, and the loading of docetaxel was up to 21.5%. The marrow depression toxicity of albumin-docetaxel nanoparticles, which could accumulate at the tumor site, was reduced. Conclusion Albumin-docetaxel nanoparticles have good targeting effect on tumor cells, which have potential value in clinical application.

参考文献/References:

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备注/Memo

备注/Memo:
南京军区南京总医院院管课题（2013055）
更新日期/Last Update: 2016-12-09