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[1]郭伟兵,李文君,段姣,等.羟考酮与吗啡在大鼠内脏痛镇痛效应的差异[J].医学研究与战创伤救治(原医学研究生学报),2018,20(04):365-370.[doi:10.3969/j.issn.1672-271X.2018.04.009]
　GUO Wei-bing,LI Wen-jun,DUAN Jiao,et al.The different antinociceptive effects of morphine and oxycodone on visceral pain in rats[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2018,20(04):365-370.[doi:10.3969/j.issn.1672-271X.2018.04.009]
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羟考酮与吗啡在大鼠内脏痛镇痛效应的差异()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第20卷
期数:
2018年04期
页码:
365-370
栏目:
基础研究
出版日期:
2018-07-20

文章信息/Info

Title:
The different antinociceptive effects of morphine and oxycodone on visceral pain in rats
作者:
郭伟兵; 李文君; 段姣; 陈春龙; 胡玉萍; 刘清珍; 张利东; 李伟彦
作者单位：210002南京，南方医科大学金陵医院（南京军区南京总医院）麻醉科（郭伟兵、李文君、段姣、陈春龙、胡玉萍、刘清珍、张利东、李伟彦）
Author(s):
GUO Wei-bing;  LI Wen-jun;  DUAN Jiao;  CHEN Chun-long;  HU Yu-ping;  LIU Qing-zhen;  ZHANG Li-dong;  LI Wei-yan
（Department of Anesthesiology, Southern Medical University, Jinling Hospital/Nanjing General Hospital of Nanjing Military Region, PLA, Nanjing 210002，Jiangsu, China）
关键词:
内脏痛; 羟考酮; 吗啡; 阿片受体
Keywords:
visceral pain; oxycodone; morphine; opioid receptor
分类号:
R735.1
DOI:
10.3969/j.issn.1672-271X.2018.04.009
文献标志码:
A
摘要:
目的 比较内脏痛及炎性痛模型中羟考酮与吗啡的镇痛强度，并初步探讨羟考酮在内脏痛模型镇痛效应中μ、κ受体的比例。方法 SD大鼠360只。其中156只SD大鼠以腹腔注射2%醋酸4mL/kg引起扭体反应作为内脏痛模型，随机均分为13组，分别为内脏痛对照组，羟考酮（04、064、1.0、1.6、2.6、4.2mg/kg）组，吗啡（04、064、1.0、1.6、2.6、4.2mg/kg）组；另将180只SD大鼠以左足底注射5%甲醛作为炎性痛模型，随机均分为15组，分别为炎性痛对照组，羟考酮(06、096
Abstract:
Objective To compare the analgesia effect between oxycodone and morphine in different pain models and the proportion of μ receptor and κreceptor in the analgesic effect of oxycodone in visceral pain model.Methods Totally three hundred and sixty male SD rats (weighted from 200 to 240 g) were used. One hundred and fifty-six rats intraperitoneally injected with 2% acetic acid (4 mL/kg), as experimental model of visceral pain, were randomly divided into thirteen groups (twelve rats per group), including control group, oxycodone (04, 064, 1.0, 1.6, 2.6, 4.2 mg/kg) group, and morphine (04, 064, 1.0, 1.6, 2.6, 4.2 mg/kg) group. One hundred and eighty SD rats were injected with 5% formalin in the left plantar to mimic inflammatory pain model and rando-mly divided into fifteen groups (twelve rats per each group), Including the control group, oxycodone (060, 096, 1.54, 2.46, 3.9, 6.3, 10 mg/kg) group, and morphine (060, 096, 1.54, 2.46, 3.9, 6.3, 10 mg/kg) group. The ED50 of oxycodone and morphine were calculated in acetic acid writhing test and formalin inflammatory pain model via behavioral pharmacology. According to oxycodone ED50 in acetic acid writhing model, twenty four SD rats were randomly divided into four groups (six rats per group), including control group (D group), 2% 4 mL/kg acetate and oxycodone ED50 dose group (E group), κ receptor antagonist and oxycodone ED50 group (K group)，μ opioid receptor antagonist and oxycodone ED50 group (U group). The number of writhing was calculated in 60 minutes.Results In 2% acetic acid writhing model, oxycodone ED50 was 06602 mg/kg (95%CI=002712-16.07 mg/kg), morphine ED50 was 1.942 mg/kg (95%CI=02773-13.60 mg/kg). The ED50 ratio of oxycodone and morphine was 1∶2.94. In 5% formalin inflammatory pain model, the phase I oxycodone ED50 was 1.921 mg/kg (95%CI=1.199-3.077 mg/kg), morphine ED50 was 4.484 mg/kg (95%CI=1.797-11.19 mg/kg). The ratio of oxycodone and morphine was 1∶2.334. Phase II oxycodone ED50 was 2.262 mg/kg (95%CI=1.378-3.715 mg/kg), morphine ED50 was 3.812 mg/kg (95%CI=1.769-8.213 mg/kg). The ratio of oxycodone and morphine was 1∶1.69. The ratio of oxycodone ED50/morphine ED50 in the phase II of 5% formalin inflammatory pain model was higher than 2% acetic acid writhing test model. In 2% writhing test model, the average writhing frequency in D group, E group, K group, and U group was (45.8±2.5), (22.5±2.4), (37.8±1.7), (26.8±2.1), respectively. The proportion of the μreceptor and κreceptor in the analgesic effect of oxycodone was 2.375∶1 in writhing test model.Conclusion The ED50 ratio of oxycodone and morphine in phase I and phase II of formalin inflammatory pain models is higher than that in writhing test model. It may be associated with oxycodone excited κ receptor predominate, The proportion of the μ receptor and κ receptor in the analgesic effect of oxycodone is 2.375∶1 in the 2% acetic acid writhing test.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2018-07-20